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Applications of Microfluidic Devices for Urology

Han SJ, Park HK, Kim KS

Microfluidics is considered an important technology that is suitable for numerous biomedical applications, including cancer diagnosis, metastasis, drug delivery, and tissue engineering. Although microfluidics is still considered to be a...
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Organ-on-a-chip and the kidney

Kim S, Takayama S

Traditional approaches to pathophysiology are advancing but still have many limitations that arise from real biologic systems and their associated physiological phenomena being too complicated. Microfluidics is a novel technology...
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Development of a New Blood Typing Kit Using the Microfluidics Separation Technique

Suh IB, Ryu SW, Lee Y, Hur DS, Chung C, Chang JK, Lim CS

BACKGROUND: Blood typing is an essential test for transfusion. Generally, blood typing is performed using a slide test, tube test or microcolumn agglutination test. The aims of this study were...
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Progress in Automated Urinalysis

Oyaert M, Delanghe J

New technological advances have paved the way for significant progress in automated urinalysis. Quantitative reading of urinary test strips using reflectometry has become possible, while complementary metal oxide semiconductor (CMOS)...
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Current Methods of Circulating Tumor Cell Detection

Lim M, Cho YK

Liquid biopsy, the analysis of circulating biomarkers from peripheral blood, such as circulating tumor cells (CTCs) and circulating tumor DNA, and exosomes, offers a less invasive, new source of cancer-derived...
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Microengineered Platforms for Co-Cultured Mesenchymal Stem Cells towards Vascularized Bone Tissue Engineering

Park H, Lim DJ, Sung M, Lee SH, Na D, Park H

Bone defects are common disease requiring thorough treatments since the bone is a complex vascularized tissue that is composed of multiple cell types embedded within an intricate extracellular matrix (ECM)....
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Paper-Based Analytical Device for Quantitative Urinalysis

Jeong SG, Kim J, Nam JO, Song YS, Lee CS

  • KMID: 2233002
  • Int Neurourol J.
  • 2013 Dec;17(4):155-161.
Paper-based analytical devices are fluidic chips fabricated with extremely inexpensive materials, namely paper, thereby allowing their use as a zero-cost analytical device in third-world countries that lack access to expensive...
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Relationship between Pericytes and Endothelial Cells in Retinal Neovascularization: A Histological and Immunofluorescent Study of Retinal Angiogenesis

Choi SH, Chung M, Park SW, Jeon NL, Kim JH, Yu YS

PURPOSE: To evaluate the relationship between pericytes and endothelial cells in retinal neovascularization through histological and immunofluorescent studies. METHODS: C57BL/6J mice were exposed to hyperoxia from postnatal day (P) 7 to...
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Recent Progress in Lab-on-a-Chip Technology and Its Potential Application to Clinical Diagnoses

Lee NY

  • KMID: 2232849
  • Int Neurourol J.
  • 2013 Mar;17(1):2-10.
We present the construction of the lab-on-a-chip (LOC) system, a state-of-the-art technology that uses polymer materials (i.e., poly[dimethylsiloxane]) for the miniaturization of conventional laboratory apparatuses, and show the potential use...
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Microfluidic Spinning of the Fibrous Alginate Scaffolds for Modulation of the Degradation Profile

Mun CH, Hwang JY, Lee SH

In tissue engineering, alginate has been an attractive material due to its biocompatibility and ability to form hydrogels, unless its uncontrollable degradation could be an undesirable feature. Here, we developed...
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Neural Stem Cell Differentiation Using Microfluidic Device-Generated Growth Factor Gradient

Kim JH, Sim J, Kim HJ

Neural stem cells (NSCs) have the ability to self-renew and differentiate into multiple nervous system cell types. During embryonic development, the concentrations of soluble biological molecules have a critical role...
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Single Nucleotide Polymorphisms Associated with Alcohol-Induced Flushing Syndrome in Korean Population

Lee JH, Seo HJ, Cho S, Kim MY, Lee SD

Alcohol-induced flushing syndrome is one of the alcohol hypersensitivity reactions commonly found among Asian population. This study was designed to find markers that can predict this particular propensity among Korean...
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Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells

An D, Kim K, Kim J

  • KMID: 2170631
  • Biomol Ther.
  • 2014 Jul;22(4):355-362.
We have developed a fully automated high throughput drug screening (HTDS) system based on the microfluidic cell culture array to perform combinational chemotherapy. This system has 64 individually addressable cell...
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Indirect Co-Culture of Stem Cells from Human Exfoliated Deciduous Teeth and Oral Cells in a Microfluidic Platform

Kang KJ, Ju SM, Jang YJ, Kim J

Oral epithelial-mesenchymal interactions play a key role in tooth development and assist differentiation of dental pulp. Many epithelial and mesenchymal factors in the microenvironment influence dental pulp stem cells to...
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Dielectrophoretic force measurement of red blood cells exposed to oxidative stress using optical tweezers and a microfluidic chip

Jeon HJ, Lee H, Yoon DS, Kim BM

Red blood cell (RBC) dysfunction is often associated with a pathological intervention, and it has been proposed as a critical risk factor for certain lethal diseases. Examining the cell viability...
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Changes in the Physical Properties of Irradiated Red Blood Cells

Kim YK, Park JR, Kim DH, Kwon EH, Kim EJ, Won DI, Shin S, Suh JS

  • KMID: 1909647
  • Korean J Blood Transfus.
  • 2007 Dec;18(3):129-137.
BACKGROUND: Irradiation of cellular blood products is the current method used for the prevention of transfusion-associated graft-versus-host disease. However, irradiation has been shown to cause biochemical changes in stored red...
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Flow Shear Stress Enhances the Proliferative Potential of Cultured Radial Glial Cells Possibly Via an Activation of Mechanosensitive Calcium Channel

Park MG, Jang H, Lee SH, Lee CJ

Radial glial cells (RGCs) which function as neural stem cells are known to be non-excitable and their proliferation depends on the intracellular calcium (Ca²⁺) level. It has been well established...
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Analytical Performance and Reference Interval of a Microfluidic Viscometer, Viscore-300 for the Measurement of Whole Blood Viscosity

Kwon YJ, Lee JH, Moon J, Kim HR, Choi HJ, Kim SH, Won Y, Shin MG

BACKGROUND: Whole blood viscosity (WBV) refers to the internal resistance that occurs when blood flows through blood vessels. WBV is known to be related to many diseases including cardiovascular and...
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Accuracy of serum-specific IgE test with microfluidic array enzyme-linked immunosorbent assay for diagnosing inhalant allergen sensitization in asthma and/or rhinitis allergy patients in Jakarta, Indonesia

Sinurat J, Rengganis , Rumende CM, Harimurti

BACKGROUND: Asthma and allergic rhinitis are a global health burden. Inhalant allergens worsen the symptoms and clinical manifestations of asthma and allergic rhinitis. Skin prick test is the gold standard...
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