- Combination of In Vivo [¹²³I]FP-CIT SPECT and Microdialysis Reveals an Antipsychotic Drug Haloperidol-induced Synaptic Dopamine Availability in the Rat Midbrain and Striatum
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Park SH, Song YS, Moon BS, Lee BC, Park HS, Kim SE
- KMID: 2463715
- Exp Neurobiol.
- 2019 Oct;28(5):602-611.
- doi: 10.5607/en.2019.28.5.602
Synaptic dopamine (DA) is mainly regulated by the presynaptic DA transporter (DAT). Single-photon emission computerized tomography (SPECT) with the DAT radiotracer [¹²³I]FP-CIT assesses changes in synaptic DA availability when endogenous... -
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- Change of Extracellular Glutamate Level in Striatum during Deep Brain Stimulation of the Entopeduncular Nucleus in Rats
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Lee HJ, Sung JH, Hong JT, Kim IS, Yang SH, Cho CB
- KMID: 2441560
- J Korean Neurosurg Soc.
- 2019 Mar;62(2):166-174.
- doi: 10.3340/jkns.2018.0122
OBJECTIVE: Globus pallidus interna (GPi) is acknowledged as an essential treatment for advanced Parkinson’s disease (PD). Nonetheless, the neurotransmitter study about its results is undiscovered. The goal of this research... -
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- Striatal Glutamate and GABA after High Frequency Subthalamic Stimulation in Parkinsonian Rat
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Lee KJ, Shim I, Sung JH, Hong JT, Kim IS, Cho CB
- KMID: 2374874
- J Korean Neurosurg Soc.
- 2017 Feb;60(2):138-145.
- doi: 10.3340/jkns.2016.0202.020
OBJECTIVE: High frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment of advanced Parkinson’s disease. However, the neurochemical basis of its effects remains unknown. The... -
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- The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain
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Kim DY, Chae JW, Lim CH, Heo BH, Park KS, Lee HG, Choi JI, Yoon MH, Kim WM
- KMID: 2327637
- Korean J Pain.
- 2016 Jul;29(3):164-171.
- doi: 10.3344/kjp.2016.29.3.164
BACKGROUND: Nefopam has been known as an inhibitor of the reuptake of monoamines, and the noradrenergic and/or serotonergic system has been focused on as a mechanism of its analgesic action.... -
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- Significance of Bioelectrical Impedance Change after Ischemia and Reperfusion Injury in Liver and What it Causes?
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Yun SS
- KMID: 2168258
- Hanyang Med Rev.
- 2013 Aug;33(3):154-159.
- doi: 10.7599/hmr.2013.33.3.154
PURPOSE: Ischemia and reperfusion (I/R) injury is a major cause of hepatic failure after liver surgery, but there is no direct method to monitor it in real-time (like an ECG... -
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- Neuroprotective Effects by Nimodipine Treatment in the Experimental Global Ischemic Rat Model : Real Time Estimation of Glutamate
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Choi SK, Lee GJ, Choi S, Kim YJ, Park HK, Park BJ
- KMID: 1442685
- J Korean Neurosurg Soc.
- 2011 Jan;49(1):1-7.
- doi: 10.3340/jkns.2011.49.1.1
OBJECTIVE: Glutamate is a key excitatory neurotransmitter in the brain, and its excessive release plays a key role in the development of neuronal injury. In order to define the effect... -
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- Impaired Cation Transport May Lead to Bioelectrical Impedance Changes during Hepatic Ischemia
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Cui ML, Ahn HS, Kim JY, Lee DS, Kim HJ, Yun SS
- KMID: 2211970
- J Korean Surg Soc.
- 2010 Jun;78(6):390-397.
- doi: 10.4174/jkss.2010.78.6.390
PURPOSE: Ischemia and reperfusion (I/R) injury is a major cause of hepatic failure after liver surgery, but there is no direct method to monitor it in real-time (like an electrocardiogram... -
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- Detection of Ammino Acids Using Microdialysis Technique and Changes of Amino Acid Concentrations in Experimentally Induced Nasal Allergy Model
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Roh HJ, Suh JC, Lee HS, Goh EK, Chon KM
- KMID: 2276389
- Korean J Otolaryngol-Head Neck Surg.
- 2005 Apr;48(4):476-481.
BACKGROUND AND OBJECTIVES: The basic principle of microdialysis is to mimic the function of a capillary blood vessel by perfusing physiologic liquid implanted into the target tissue. Amino acids are... -
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- The Time Course of the Changes in Lactate Produced by Incisions in the Rat
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Cha YD, Lee HS, Han JU, Jung JK, Lee CS, Shin SH, Lim HK, Kim TJ
- KMID: 2104841
- J Korean Pain Soc.
- 2004 Dec;17(2):125-130.
- doi: 10.3344/jkps.2004.17.2.125
BACKGROUND: It is well known that the level of lactate increases in wounds, which is not necessarily caused by a limitation of oxygen delivery, so may not primarily indicate ischemia.... -
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- Hydroxyl Radical Production after Intrastriatal Injection of Dopamine and the Effect of Growth Hormone on the Apoptosis of Striatal Neurons Injured by Hypoxia-ischemia in Newborn Rat Brain
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Cho JJ, Yu J, Jee YH, Lee SB, Oh SY, Kim HG, Chang YP
- KMID: 1568741
- J Korean Soc Pediatr Endocrinol.
- 2004 Dec;9(2):145-151.
PURPOSE:We investigated the production of oxygen hydroxyl radicals in the striatum of neonatal rat brain after intrastriatal injection of dopamine (DA) and the effect of growth hormone (GH) on the... -
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- Monoaminergic Activity by Drugs Acting on Adrenergic alpha2-receptors in Rat Hippocampus and Primary Visual Cortex
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Kim HG, Lee YC, Paik KC, Lim MH, Kim HW, Kang BJ
- KMID: 2286867
- Korean J Psychopharmacol.
- 2004 Sep;15(3):371-379.
OBJECTIVE: The aim of the this study was to compare the effects of clonidine (a alpha2-adrenoceptor and imidazoline receptor agonist), yohimbine (a selective alpha2-adrenoceptor antagonist) and idazoxan (a alpha2-adrenoceptor and... -
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- Effect of Hypoxia-Ischemia on Striatal Monoamine Metabolism in Neonatal Rat Brains
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Jee YH, Kim HG, Park WS, Chang YP
- KMID: 1606964
- J Korean Pediatr Soc.
- 2003 Aug;46(8):789-794.
PURPOSE: We intended to evaluate the effect of hypoxia-ischemia on extracellular striatal monoamine metabolism in neonatal rat brains by in vivo microdialysis. METHODS: The right common carotid arteries of five or... -
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- Comparison of the Dopamine Response in the Rat Prefrontal Cortex Induced by Irregular and Regular Electrical Stimuli
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Chung YC, Moon SG, Eun HB, Hwang IK, Lim CW, Han JH
- KMID: 2037058
- Korean J Psychopharmacol.
- 2002 Dec;13(4):239-245.
OBJECTIVE: In general, it is known that repetitive regular stimuli induce tolerance and repetitive irregular stimuli induce sensitization. We sought to determine the dopamine response in the rat prefrontal cortex... -
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- In Vivo Microdialysis Measures of Extracellular Norepinephrine in the Rat Amygdala during Sleep-wakefulness
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Park SP
- KMID: 1101557
- J Korean Med Sci.
- 2002 Jun;17(3):395-399.
- doi: 10.3346/jkms.2002.17.3.395
Norepinephrine (NE)-containing locus ceruleus (LC) has been known to participate in the regulation of the sleep-wake cycle according to the differential firing rate. The aim of this study was to... -
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- Characterization of Norepinephrine Release in Rat Posterior Hypothalamus Using in vivo Brain Microdialysis
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Sung KW, Kim SY, Kim ON, Lee SB
- KMID: 1614852
- Korean J Physiol Pharmacol.
- 2002 Feb;6(1):9-14.
In the present study, we used the microdialysis technique combined with high performance liquid chromatography (HPLC) and electrochemical detection to measure the extracellular levels of norepinephrine (NE) in the posterior... -
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- Effects of Acute and Chronic Treatment of Olanzapine and Risperidone on the Extracellular Dopamine Concentrations of the Prefrontal Cortex in Rats
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Moon SK, Chung YC, Eun HB, Hwang IK, Park TW
- KMID: 2340641
- J Korean Neuropsychiatr Assoc.
- 2002 Jan;41(1):61-68.
OBJECT: It is reported that the effect of antipsychotics on the extracellular dopamine levels in the prefrontal cortex is related to the their effect on the negative symptoms. Therefore, we... -
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- Effects of High Fat Diet on Lipolysis in Skeletal Muscle and Adipose Tissue in Rats
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Kim CH, Chung YE, Lee SJ, Park JY, Hong SK, Kim HK, Suh KI, Lee KU
- KMID: 1767980
- J Korean Diabetes Assoc.
- 2000 Dec;24(6):641-651.
BACKGROUND: It has been hypothesized that increased fat oxidation reduces glucose utilization in skeletal muscle, and is responsible for the insulin resistance associated with obesity or high-fat feeding. In contrast,... -
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- Effect of serotonin uptake inhibitors on serotonin metabolism in the hypothalamus of freely moving rats
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Song YS, Yoon SN, Jung DS, Yoo SH, Ryu HK, Kim HG
- KMID: 1581021
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):439-444.
Tricyclic antidepressant clomipramine or selective serotonin reuptake inhibitors (SSRIs) have been commonly used for the treatment of premature ejaculation. In the present study, we analyzed the concentrations of serotonin and 5-hydroxyindoleacetic acid (5-HIAA)... -
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- Effect of Fentanyl on the TNF-alpha and IL-1beta Level during Global Ischemia/reperfusion in Rats
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Oh WS, Hong KH, Kil HY, Song DK
- KMID: 2237296
- Korean J Anesthesiol.
- 2000 Mar;38(3):546-558.
- doi: 10.4097/kjae.2000.38.3.546
BACKGROUND: To reduce surgical stress, fentanyl is frequently used for neurosurgical procedure where focal and/or global ischemia may occur. However, the effect of fentanyl on the cytokine level during... -
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- Effect of the K+ Channel Modulations on Glutamate and K+ Concentrations in Rabbit Hippocampus during Transient Global Ischemia
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Choi KT, Cho MW, Suh BT, Lee JR, Park HS, Ryu PD
- KMID: 2032296
- Korean J Anesthesiol.
- 1999 Mar;36(3):510-517.
- doi: 10.4097/kjae.1999.36.3.510
BACKGROUND: Cerebral ischemia causes an increase in extracellular potassium ([K+]e) through activation of the KATP channel. This increase in [K+]e could result in neuronal depolarization and a reversal of the... -
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