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Combination of In Vivo [¹²³I]FP-CIT SPECT and Microdialysis Reveals an Antipsychotic Drug Haloperidol-induced Synaptic Dopamine Availability in the Rat Midbrain and Striatum

Park SH, Song YS, Moon BS, Lee BC, Park HS, Kim SE

Synaptic dopamine (DA) is mainly regulated by the presynaptic DA transporter (DAT). Single-photon emission computerized tomography (SPECT) with the DAT radiotracer [¹²³I]FP-CIT assesses changes in synaptic DA availability when endogenous...
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Change of Extracellular Glutamate Level in Striatum during Deep Brain Stimulation of the Entopeduncular Nucleus in Rats

Lee HJ, Sung JH, Hong JT, Kim IS, Yang SH, Cho CB

OBJECTIVE: Globus pallidus interna (GPi) is acknowledged as an essential treatment for advanced Parkinson’s disease (PD). Nonetheless, the neurotransmitter study about its results is undiscovered. The goal of this research...
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Striatal Glutamate and GABA after High Frequency Subthalamic Stimulation in Parkinsonian Rat

Lee KJ, Shim I, Sung JH, Hong JT, Kim IS, Cho CB

OBJECTIVE: High frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment of advanced Parkinson’s disease. However, the neurochemical basis of its effects remains unknown. The...
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The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain

Kim DY, Chae JW, Lim CH, Heo BH, Park KS, Lee HG, Choi JI, Yoon MH, Kim WM

BACKGROUND: Nefopam has been known as an inhibitor of the reuptake of monoamines, and the noradrenergic and/or serotonergic system has been focused on as a mechanism of its analgesic action....
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Significance of Bioelectrical Impedance Change after Ischemia and Reperfusion Injury in Liver and What it Causes?

Yun SS

PURPOSE: Ischemia and reperfusion (I/R) injury is a major cause of hepatic failure after liver surgery, but there is no direct method to monitor it in real-time (like an ECG...
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Neuroprotective Effects by Nimodipine Treatment in the Experimental Global Ischemic Rat Model : Real Time Estimation of Glutamate

Choi SK, Lee GJ, Choi S, Kim YJ, Park HK, Park BJ

OBJECTIVE: Glutamate is a key excitatory neurotransmitter in the brain, and its excessive release plays a key role in the development of neuronal injury. In order to define the effect...
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Impaired Cation Transport May Lead to Bioelectrical Impedance Changes during Hepatic Ischemia

Cui ML, Ahn HS, Kim JY, Lee DS, Kim HJ, Yun SS

PURPOSE: Ischemia and reperfusion (I/R) injury is a major cause of hepatic failure after liver surgery, but there is no direct method to monitor it in real-time (like an electrocardiogram...
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Detection of Ammino Acids Using Microdialysis Technique and Changes of Amino Acid Concentrations in Experimentally Induced Nasal Allergy Model

Roh HJ, Suh JC, Lee HS, Goh EK, Chon KM

  • KMID: 2276389
  • Korean J Otolaryngol-Head Neck Surg.
  • 2005 Apr;48(4):476-481.
BACKGROUND AND OBJECTIVES: The basic principle of microdialysis is to mimic the function of a capillary blood vessel by perfusing physiologic liquid implanted into the target tissue. Amino acids are...
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The Time Course of the Changes in Lactate Produced by Incisions in the Rat

Cha YD, Lee HS, Han JU, Jung JK, Lee CS, Shin SH, Lim HK, Kim TJ

BACKGROUND: It is well known that the level of lactate increases in wounds, which is not necessarily caused by a limitation of oxygen delivery, so may not primarily indicate ischemia....
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Hydroxyl Radical Production after Intrastriatal Injection of Dopamine and the Effect of Growth Hormone on the Apoptosis of Striatal Neurons Injured by Hypoxia-ischemia in Newborn Rat Brain

Cho JJ, Yu J, Jee YH, Lee SB, Oh SY, Kim HG, Chang YP

  • KMID: 1568741
  • J Korean Soc Pediatr Endocrinol.
  • 2004 Dec;9(2):145-151.
PURPOSE:We investigated the production of oxygen hydroxyl radicals in the striatum of neonatal rat brain after intrastriatal injection of dopamine (DA) and the effect of growth hormone (GH) on the...
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Monoaminergic Activity by Drugs Acting on Adrenergic alpha2-receptors in Rat Hippocampus and Primary Visual Cortex

Kim HG, Lee YC, Paik KC, Lim MH, Kim HW, Kang BJ

  • KMID: 2286867
  • Korean J Psychopharmacol.
  • 2004 Sep;15(3):371-379.
OBJECTIVE: The aim of the this study was to compare the effects of clonidine (a alpha2-adrenoceptor and imidazoline receptor agonist), yohimbine (a selective alpha2-adrenoceptor antagonist) and idazoxan (a alpha2-adrenoceptor and...
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Effect of Hypoxia-Ischemia on Striatal Monoamine Metabolism in Neonatal Rat Brains

Jee YH, Kim HG, Park WS, Chang YP

  • KMID: 1606964
  • J Korean Pediatr Soc.
  • 2003 Aug;46(8):789-794.
PURPOSE: We intended to evaluate the effect of hypoxia-ischemia on extracellular striatal monoamine metabolism in neonatal rat brains by in vivo microdialysis. METHODS: The right common carotid arteries of five or...
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Comparison of the Dopamine Response in the Rat Prefrontal Cortex Induced by Irregular and Regular Electrical Stimuli

Chung YC, Moon SG, Eun HB, Hwang IK, Lim CW, Han JH

  • KMID: 2037058
  • Korean J Psychopharmacol.
  • 2002 Dec;13(4):239-245.
OBJECTIVE: In general, it is known that repetitive regular stimuli induce tolerance and repetitive irregular stimuli induce sensitization. We sought to determine the dopamine response in the rat prefrontal cortex...
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In Vivo Microdialysis Measures of Extracellular Norepinephrine in the Rat Amygdala during Sleep-wakefulness

Park SP

Norepinephrine (NE)-containing locus ceruleus (LC) has been known to participate in the regulation of the sleep-wake cycle according to the differential firing rate. The aim of this study was to...
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Characterization of Norepinephrine Release in Rat Posterior Hypothalamus Using in vivo Brain Microdialysis

Sung KW, Kim SY, Kim ON, Lee SB

  • KMID: 1614852
  • Korean J Physiol Pharmacol.
  • 2002 Feb;6(1):9-14.
In the present study, we used the microdialysis technique combined with high performance liquid chromatography (HPLC) and electrochemical detection to measure the extracellular levels of norepinephrine (NE) in the posterior...
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Effects of Acute and Chronic Treatment of Olanzapine and Risperidone on the Extracellular Dopamine Concentrations of the Prefrontal Cortex in Rats

Moon SK, Chung YC, Eun HB, Hwang IK, Park TW

  • KMID: 2340641
  • J Korean Neuropsychiatr Assoc.
  • 2002 Jan;41(1):61-68.
OBJECT: It is reported that the effect of antipsychotics on the extracellular dopamine levels in the prefrontal cortex is related to the their effect on the negative symptoms. Therefore, we...
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Effects of High Fat Diet on Lipolysis in Skeletal Muscle and Adipose Tissue in Rats

Kim CH, Chung YE, Lee SJ, Park JY, Hong SK, Kim HK, Suh KI, Lee KU

  • KMID: 1767980
  • J Korean Diabetes Assoc.
  • 2000 Dec;24(6):641-651.
BACKGROUND: It has been hypothesized that increased fat oxidation reduces glucose utilization in skeletal muscle, and is responsible for the insulin resistance associated with obesity or high-fat feeding. In contrast,...
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Effect of serotonin uptake inhibitors on serotonin metabolism in the hypothalamus of freely moving rats

Song YS, Yoon SN, Jung DS, Yoo SH, Ryu HK, Kim HG

  • KMID: 1581021
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):439-444.
Tricyclic antidepressant clomipramine or selective serotonin reuptake inhibitors (SSRIs) have been commonly used for the treatment of premature ejaculation. In the present study, we analyzed the concentrations of serotonin and 5-hydroxyindoleacetic acid (5-HIAA)...
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Effect of Fentanyl on the TNF-alpha and IL-1beta Level during Global Ischemia/reperfusion in Rats

Oh WS, Hong KH, Kil HY, Song DK

BACKGROUND: To reduce surgical stress, fentanyl is frequently used for neurosurgical procedure where focal and/or global ischemia may occur. However, the effect of fentanyl on the cytokine level during...
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Effect of the K+ Channel Modulations on Glutamate and K+ Concentrations in Rabbit Hippocampus during Transient Global Ischemia

Choi KT, Cho MW, Suh BT, Lee JR, Park HS, Ryu PD

BACKGROUND: Cerebral ischemia causes an increase in extracellular potassium ([K+]e) through activation of the KATP channel. This increase in [K+]e could result in neuronal depolarization and a reversal of the...
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