- The role of promoter methylation in Epstein-Barr virus (EBV) microRNA expression in EBV-infected B cell lines
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Kim DN, Song YJ, Lee SK
- KMID: 1015459
- Exp Mol Med.
- 2011 Jul;43(7):401-410.
- doi: 10.3858/emm.2011.43.7.044
Epstein-Barr virus (EBV) microRNAs (miRNAs) are expressed in EBV-associated tumors and cell lines, but the regulation mechanism of their expression is unclear yet. We investigated whether the expression of EBV... -
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- Developmental changes in hematopoietic stem cell properties
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Copley MR, Eaves CJ
- KMID: 2154274
- Exp Mol Med.
- 2013 Nov;45(11):e55.
Hematopoietic stem cells (HSCs) comprise a rare population of cells that can regenerate and maintain lifelong blood cell production. This functionality is achieved through their ability to undergo many divisions... -
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- The biological complexity of RKIP signaling in human cancers
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Farooqi AA, Li Y, Sarkar FH
- KMID: 2155439
- Exp Mol Med.
- 2015 Sep;47(9):e185.
- doi: 10.1038/emm.2015.70
The Raf kinase inhibitory protein (RKIP) has been demonstrated to modulate different intracellular signaling pathways in cancers. Studies have shown that RKIP is frequently downregulated in cancers; therefore, attempts have... -
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- MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes
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Zhang Y, Jia J, Yang S, Liu X, Ye S, Tian H
- KMID: 2155344
- Exp Mol Med.
- 2014 Feb;46(2):e79.
- doi: 10.1038/emm.2013.152
Osteoarthritis is a common cause of functional deterioration in older adults and is an immense burden on the aging population. Altered chondrogenesis is the most important pathophysiological process involved in... -
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- MicroRNAs in Human Embryonic and Cancer Stem Cells
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Navarro A, Monzo M
- KMID: 1071411
- Yonsei Med J.
- 2010 Sep;51(5):622-632.
- doi: 10.3349/ymj.2010.51.5.622
MicroRNAs (miRNAs) are small non-coding RNAs that regulate messenger RNAs at the post-transcriptional level. They play an important role in the control of cell physiological functions, and their alterations have... -
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- miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFkappaB1
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Arora H, Qureshi R, Jin S, Park AK, Park WY
- KMID: 1009969
- Exp Mol Med.
- 2011 May;43(5):298-304.
- doi: 10.3858/emm.2011.43.5.031
The activation of nuclear factor-kappa B1 (NFkappaB1) in cancer cells may confer resistance to ionizing radiation (IR). To enhance the therapeutic efficiency of IR in lung cancer, we screened for... -
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- Epstein-Barr virus latent genes
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Kang MS, Kieff E
- KMID: 2155396
- Exp Mol Med.
- 2015 Jan;47(1):e131.
- doi: 10.1038/emm.2014.84
Latent Epstein-Barr virus (EBV) infection has a substantial role in causing many human disorders. The persistence of these viral genomes in all malignant cells, yet with the expression of limited... -
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- MiR-17-5p modulates osteoblastic differentiation and cell proliferation by targeting SMAD7 in non-traumatic osteonecrosis
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Jia J, Feng X, Xu W, Yang S, Zhang Q, Liu X, Feng Y, Dai Z
- KMID: 2155372
- Exp Mol Med.
- 2014 Jul;46(7):e107.
- doi: 10.1038/emm.2014.43
MicroRNAs (miRNAs) have recently been recognized to have a role in human orthopedic disorders. The objective of our study was to explore the expression profile and biological function of miRNA-17-5p... -
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- microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish
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Kim CW, Han JH, Wu L, Choi JY
- KMID: 2418861
- Yonsei Med J.
- 2018 Jan;59(1):141-147.
- doi: 10.3349/ymj.2018.59.1.141
PURPOSE: microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiation in various organs by silencing specific RNAs and regulating gene expression. In the... -
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- Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-beta in colorectal cells
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He YQ, Sheng JQ, Ling XL, Fu L, Jin P, Yen L, Rao J
- KMID: 1402316
- Exp Mol Med.
- 2012 Dec;44(12):723-732.
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-positive tumors.... -
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- Identification of miR-23a as a novel microRNA normalizer for relative quantification in human uterine cervical tissues
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Shen Y, Li Y, Ye F, Wang F, Wan X, Lu W, Xie X
- KMID: 1107377
- Exp Mol Med.
- 2011 Jun;43(6):358-366.
- doi: 10.3858/emm.2011.43.6.039
Quantitative real-time RT-PCR (RT-qPCR) is being widely used in microRNA expression research. However, few reports detailed a robust identification and validation strategy for suitable reference genes for normalisation in microRNA... -
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- MicroRNA-103a-3p controls proliferation and osteogenic differentiation of human adipose tissue-derived stromal cells
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Kim DS, Lee SY, Lee JH, Bae YC, Jung JS
- KMID: 2155426
- Exp Mol Med.
- 2015 Jul;47(7):e172.
- doi: 10.1038/emm.2015.39
The elucidation of the molecular mechanisms underlying the differentiation and proliferation of human adipose tissue-derived stromal cells (hADSCs) represents a critical step in the development of hADSCs-based cellular therapies. To... -
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- Genomic assays for Epstein-Barr virus-positive gastric adenocarcinoma
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Gulley ML
- KMID: 2155399
- Exp Mol Med.
- 2015 Jan;47(1):e134.
- doi: 10.1038/emm.2014.93
A small set of gastric adenocarcinomas (9%) harbor Epstein-Barr virus (EBV) DNA within malignant cells, and the virus is not an innocent bystander but rather is intimately linked to pathogenesis... -
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- Inhibition by miR-410 facilitates direct retinal pigment epithelium differentiation of umbilical cord blood-derived mesenchymal stem cells
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Choi SW, Kim JJ, Seo MS, Park SB, Shin TH, Shin JH, Seo Y, Kim HS, Kang KS
- KMID: 2412588
- J Vet Sci.
- 2017 Mar;18(1):59-65.
- doi: 10.4142/jvs.2017.18.1.59
Retinal pigment epithelium (RPE) is a major component of the eye. This highly specialized cell type facilitates maintenance of the visual system. Because RPE loss induces an irreversible visual impairment,... -
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- Therapeutic effects of recombinant Salmonella typhimurium harboring CCL22 miRNA on atopic dermatitis-like skin in mice
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Yoon WS, Lee SS, Chae YS, Park YK
- KMID: 1097263
- Exp Mol Med.
- 2011 Feb;43(2):63-70.
- doi: 10.3858/emm.2011.43.2.008
Th-2-biased immune responses are known to play a key role in the pathogenesis of atopic dermatitis. In particular, the macrophage-derived chemokine CCL22 is directly implicated in Th-2-associated skin inflammatory reactions,... -
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- Suitable reference genes for relative quantification of miRNA expression in prostate cancer
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Schaefer A, Jung M, Miller K, Lein M, Kristiansen G, Erbersdobler A, Jung K
- KMID: 994398
- Exp Mol Med.
- 2010 Nov;42(11):749-758.
- doi: 10.3858/emm.2010.42.11.076
Real time quantitative PCR (qPCR) is the method of choice for miRNA expression studies. For relative quantification of miRNAs, normalization to proper reference genes is mandatory. Currently, no validated reference... -
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