- Kinetin inhibits apoptosis of aging spleen cells induced by D-galactose in rats
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Li M, Ouyang W, Wu X, Zheng Y, Wei Y, An L
- KMID: 2155618
- J Vet Sci.
- 2014 Sep;15(3):353-359.
- doi: 10.4142/jvs.2014.15.3.353
Kinetin (Kn) is a cytokinin growth factor that exerts several anti-aging and antioxidant effects on cells and organs. To investigate the mechanism underlying apoptotic events in aging cells induced by... -
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- A Novel Synthetic Compound 3-Amino-3-(4-Fluoro-Phenyl)-1H-Quinoline-2,4-Dione (KR22332) Exerts a Radioprotective Effect via the Inhibition of Mitochondrial Dysfunction and Generation of Reactive Oxygen Species
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Baek SJ, Chang JW, Park KH, Yang GY, Hwang HS, Koh YW, Jung YS, Kim CH
- KMID: 2130811
- Yonsei Med J.
- 2014 Jul;55(4):886-894.
- doi: 10.3349/ymj.2014.55.4.886
PURPOSE: Acute side effects of radiation such as oral mucositis are observed in most patients. Although several potential radioprotective agents have been proposed, no effective agent has yet been identified.... -
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- Bisphenol A Impairs Mitochondrial Function in the Liver at Doses below the No Observed Adverse Effect Level
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Moon MK, Kim MJ, Jung IK, Koo YD, Ann HY, Lee KJ, Kim SH, Yoon YC, Cho BJ, Park KS, Jang HC, Park YJ
- KMID: 1421617
- J Korean Med Sci.
- 2012 Jun;27(6):644-652.
- doi: 10.3346/jkms.2012.27.6.644
Bisphenol A (BPA) has been reported to possess hepatic toxicity. We investigated the hypothesis that BPA, below the no observed adverse effect level (NOAEL), can induce hepatic damage and mitochondrial... -
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- Cardioprotection Via Modulation of Calcium Homeostasis by Thiopental in Hypoxia-Reoxygenated Neonatal Rat Cardiomyocytes
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Kim HS, Hwang KC, Park WK
- KMID: 1126016
- Yonsei Med J.
- 2010 Mar;51(2):187-196.
- doi: 10.3349/ymj.2010.51.2.187
PURPOSE: Ca2+ homeostasis plays an important role in myocardial cell injury induced by hypoxia-reoxygenation, and prevention of intracellular Ca2+ overload is key to cardioprotection. Even though thiopental is a frequently... -
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- Hydroxydibenzoylmethane induces apoptosis through repressing ornithine decarboxylase in human promyelocytic leukemia HL-60 cells
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Wang MF, Liao YF, Hung YC, Lin CL, Hour TC, Lue KH, Hung HC, Liu GY
- KMID: 1104388
- Exp Mol Med.
- 2011 Apr;43(4):189-196.
- doi: 10.3858/emm.2011.43.4.023
Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis and a target for chemoprevention. Hydroxydibenzoylmethane (HDB), a derivative of dibenzoylmethane of licorice, is a promising chemopreventive agent. In this... -
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- Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model
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Kim IH, Kim SW, Kim SH, Lee SO, Lee ST, Kim DG, Lee MJ, Park WH
- KMID: 1397449
- Exp Mol Med.
- 2012 Jul;44(7):448-456.
Parthenolide (PT), a sesquiterpene lactone derived from the plant feverfew, has pro-apoptotic activity in a number of cancer cell types. We assessed whether PT induces the apoptosis of hepatic stellate... -
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- Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction
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Choi JH, Choi AY, Yoon H, Choe W, Yoon KS, Ha J, Yeo EJ, Kang I
- KMID: 1115265
- Exp Mol Med.
- 2010 Dec;42(12):811-822.
- doi: 10.3858/emm.2010.42.12.084
Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi and possesses various effects, including cytoprotection and anti-inflammation. Because endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases,... -
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- Resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine
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Lee MK, Kang SJ, Poncz M, Song KJ, Park KS
- KMID: 1047089
- Exp Mol Med.
- 2007 Jun;39(3):376-384.
Dopamine (DA) is an oxidant that may contribute to the degeneration of dopaminergic neurons. The present study demonstrates that DA-induced cytotoxicity in human-derived neurotypic cells, SH-SY5Y, is prevented by resveratrol,... -
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