- Desynchronization of Theta Oscillations in Prefrontal Cortex during Self-stimulation of the Medial Forebrain Bundles in Mice
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Hwang E, Lee H, Choi JH
- KMID: 2416245
- Exp Neurobiol.
- 2018 Jun;27(3):181-188.
- doi: 10.5607/en.2018.27.3.181
Stimulation of the medial forebrain bundle (MFB) can reinforce intracranial self-stimulation (ICSS) in rodents (i.e., reward-seeking behavior). The MFB stimulation produces a highly reliable behavioral output that enabled a clear... -
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- Impaired Voluntary Wheel Running Behavior in the Unilateral 6-Hydroxydopamine Rat Model of Parkinson's Disease
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Pan Q, Zhang W, Wang J, Luo F, Chang J, Xu R
- KMID: 2191187
- J Korean Neurosurg Soc.
- 2015 Feb;57(2):82-87.
- doi: 10.3340/jkns.2015.57.2.82
OBJECTIVE: The aim of this study was to investigate voluntary wheel running behavior in the unilateral 6-hydroxydopamine (6-OHDA) rat model. METHODS: Male Sprague-Dawley rats were assigned to 2 groups : 6-OHDA... -
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- Spectral Modification by Operant Conditioning of Cortical Theta Suppression in Rats
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Roh M, Jang IS, Suk K, Lee MG
- KMID: 2441637
- Clin Psychopharmacol Neurosci.
- 2019 Feb;17(1):93-104.
- doi: 10.9758/cpn.2019.17.1.93
OBJECTIVE: Brain activity is known to be voluntarily controllable by neurofeedback, a kind of electroencephalographic (EEG) operant conditioning. Although its efficacy in clinical effects has been reported, it is yet... -
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- A Rat Model of Striatonigral Degeneration Generated by Simultaneous Injection of 6-Hydroxydopamine into the Medial Forebrain Bundle and Quinolinic Acid into the Striatum
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Yoon HH, Kim YH, Shin ES, Jeon SR
- KMID: 2069939
- J Korean Med Sci.
- 2014 Nov;29(11):1555-1561.
- doi: 10.3346/jkms.2014.29.11.1555
A double toxin-double lesion strategy is well-known to generate a rat model of striatonigral degeneration (SND) such as multiple system atrophy-parkinsonian type. However, with this model it is difficult to... -
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- Differential Activation of Microglia in the Substantia Nigra and Lesioned Site Following Medial Forebrain Bundle Transection
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Cho BP, Song DY, Park JC, Lee JS, Park BG, Choi BY, Kang HS
- KMID: 2224494
- Korean J Anat.
- 2004 Aug;37(4):317-327.
Medial forebrain bundle (MFB) transmits the nigrostriatal dopaminergic (DA) axons, and previously we reported that transection of the MFB causes apotosis-like neurodegeneration of nigral DA neurons. On the other hand,... -
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- Relationship between Microglial Activation and Dopaminergic Neuronal Loss in 6-OHDA-induced Parkinsonian Animal Model
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Lee JS, Lee JY, Cho WG, Yang YC, Cho BP
- KMID: 1430195
- Korean J Phys Anthropol.
- 2013 Mar;26(1):13-23.
- doi: 10.11637/kjpa.2013.26.1.13
This study assessed the dynamics of morphological and immunophenotypic properties of activated microglia in a 6-hydroxydopamine (6-OHDA) induced Parkinsonian animal model. Neurodegeneration in the substantia nigra pars compacta (SNc) was... -
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- Neuroglial Proliferative Activity Following Medial Forebrain Bundle Axotomy
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Song DY, Park JC, Park BG, Lee JS, Choi BY, Yang YC, Kang HS, Cho BP
- KMID: 2224495
- Korean J Anat.
- 2004 Aug;37(4):329-336.
Changes in morphology, immunophenotypes and proliferative activity of neuroglia are key features in most forms of CNS pathology. We compared proliferative activity of neuroglial cells in response to two different... -
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- Push-in Head Restraining Apparatus for Intracranial Self Stimulation Tasks in Rats
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Roh M, Jang IS, Lee MG
- KMID: 2285498
- Korean J Physiol Pharmacol.
- 2014 Apr;18(2):103-108.
- doi: 10.4196/kjpp.2014.18.2.103
Head restraining is an experimental technique that firmly secures the animal's head to a fixation apparatus for the precise control and sensing of behaviors. However, procedural and surgical difficulties and... -
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- The Effect of 1, 25-Dihydroxyvitamin D3 on Dopaminergic Neurons and Microglial Activation in Parkinsonian Rat Model Induced by 6-Hydroxydopamine
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Ryu SY, Kim JS, Choi YB, Han SR, Park JW, Park SK, Kim YI
- KMID: 1626910
- J Korean Neurol Assoc.
- 2005 Jun;23(3):368-373.
BACKGROUND: Recent studies have shown increasing evidence for microglial activation in neuronal degeneration in Parkinson's disease (PD), although the cause of PD remains unclear. Recent studies have also shown that... -
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- Lesion of Subthalamic Nucleus in Parkinsonian Rats: Effects of Dopamine D1 and D2 Receptor Agonists on the Neuronal Activities of the Substantia Nigra Pars Reticulata
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Park YS, Jeon MF, Lee BH, Chang JW
- KMID: 2189335
- J Korean Neurosurg Soc.
- 2007 Dec;42(6):455-461.
- doi: 10.3340/jkns.2007.42.6.455
OBJECTIVE: It was hypothesized that dopamine agonist administration and subthalamic nucleus (STN) lesion in the rat might have a synergistic effect on the neuronal activities of substantia nigra pars reticulata... -
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- Delayed Treatment of Capsaicin Produces Partial Motor Recovery by Enhancing Dopamine Function in MPPâº-lesioned Rats via Ciliary Neurotrophic Factor
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Kim KI, Baek JY, Jeong JY, Nam JH, Park ES, Bok E, Shin WH, Chung YC, Jin BK
- KMID: 2450220
- Exp Neurobiol.
- 2019 Apr;28(2):289-299.
- doi: 10.5607/en.2019.28.2.289
Transient receptor potential vanilloid subtype 1 (TRPV1) on astrocytes prevents ongoing degeneration of nigrostriatal dopamine (DA) neurons in MPPâº-lesioned rats via ciliary neurotrophic factor (CNTF). The present study determined whether... -
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- Morphological Changes in the Striatum after Dopaminergic Cell Transplantation to Parkinson's Disease Rat Model
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Baek SY, Park SJ, Jung HS, Kim YH, Kim HJ, Moon YS, Kim JW, Kim SU, Yoon S, Kim BS, Kim JB, Kim JJ
- KMID: 2030743
- Korean J Anat.
- 2001 Feb;34(1):95-105.
Parkinson's disease animal model was developed by the destruction of the striatonigral dopaminergic system. The morphological changes in the dopamine depleted striatum after the transplantation of the fetal mesencephalic dopaminergic... -
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- Enhanced Efficacy of Human Brain-Derived Neural Stem Cells by Transplantation of Cell Aggregates in a Rat Model of Parkinson's Disease
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Shin ES, Hwang O, Hwang YS, Suh JK, Chun YI, Jeon SR
- KMID: 2018095
- J Korean Neurosurg Soc.
- 2014 Nov;56(5):383-389.
- doi: 10.3340/jkns.2014.56.5.383
OBJECTIVE: Neural tissue transplantation has been a promising strategy for the treatment of Parkinson's disease (PD). However, transplantation has the disadvantages of low-cell survival and/or development of dyskinesia. Transplantation of... -
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