- THE ROLE OF REGULATED PROTEINS RELATED TO CELL CYCIE IN CARCINOGENESIS
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Kwak DH, Lee SH, Kim CH
- KMID: 2190615
- J Korean Assoc Oral Maxillofac Surg.
- 1997 Jul;23(3):374-387.
The cell cycle is composed of G1, S, G2 and M phase. The transitions between different phases are regulated at checkpoint such as Start(restriction), S phase and mitotic checkpoint. These... -
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- MAD2 Expression in Ovarian Carcinoma: Different Expression Patterns and Levels among Various Types of Ovarian Carcinoma and Its Prognostic Significance in High-Grade Serous Carcinoma
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Park PE, Jeong JY, Kim SZ, Park JY
- KMID: 2141002
- Korean J Pathol.
- 2013 Oct;47(5):418-425.
BACKGROUND: Mitotic arrest deficiency protein 2 (MAD2) is a key component of spindle assembly checkpoint function, which mediates cell apoptosis through microtubule kinetics. Aberrant expression of MAD2 is believed to... -
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- Inhibitory Effect of Melanoma Differentiation Associated Gene-7/Interleukin-24 on Invasion In Vitro of Human Melanoma Cancer Cells
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Lin BW, Jiao ZL, Fan JF, Peng L, Li L, Zhao ZG, Ding XY, Li HJ
- KMID: 2158029
- J Korean Med Sci.
- 2013 Jun;28(6):833-839.
- doi: 10.3346/jkms.2013.28.6.833
The acquisition of metastasis potential is a critical point for malignant tumors. Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a potential tumor suppress gene and frequently down-regulated in malignant tumors. It... -
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- Mutational Analysis of TTK Gene in Gastric and Colorectal Cancers with Microsatellite Instability
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Ahn CH, Kim YR, Kim SS, Yoo NJ, Lee SH
- KMID: 1972676
- Cancer Res Treat.
- 2009 Dec;41(4):224-228.
PURPOSE: The TTK gene plays a crucial role in regulation of the mitotic checkpoint. The TTK gene has an A9 mononucleotide repeat in the coding sequences, which harbors mutations in... -
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- Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells
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Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH
- KMID: 2069926
- J Korean Med Sci.
- 2014 Nov;29(11):1464-1472.
- doi: 10.3346/jkms.2014.29.11.1464
Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition... -
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- Partial Hepatectomy in Acetylation-Deficient BubR1 Mice Corroborates that Chromosome Missegregation Initiates Tumorigenesis
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Lee YK, Park I, Lee H
- KMID: 2384255
- Endocrinol Metab.
- 2014 Dec;29(4):561-566.
- doi: 10.3803/EnM.2014.29.4.561
BACKGROUND: Aneuploidy has been suggested as one of the major causes of cancer from the time of Boveri. In support of this notion, many studies have shown that cancer cells... -
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- Proteomic Analysis of Anti-Proliferative Effects by Treatment of 5-Fluorouracil in Cervical Cancer Cells
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Kim CJ, Yim EK, Lee KH, Ro DY, Bae JS, Park TC, Namkoong S, Um SJ, Park JS
- KMID: 2244915
- Korean J Gynecol Oncol Colposc.
- 2004 Jun;15(2):113-122.
OBJECTIVE: We investigated the effects of 5-fluorouracil (FU) to the cervical cancer cell lines with HPV in the aspect of the apoptosis and HPV. METHODS: The effects of 5-FU on apoptosis... -
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- The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles
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Park YY, Nam HJ, Do M, Lee JH
- KMID: 2361537
- Exp Mol Med.
- 2016 Aug;48(8):e250.
- doi: 10.1038/emm.2016.61
RSK2, also known as RPS6KA3 (ribosomal protein S6 kinase, 90 kDa, polypeptide 3), is a downstream kinase of the mitogen-activated protein kinase (MAPK) pathway, which is important in regulating survival, transcription,... -
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