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The effect of ultraviolet-B irradiated donor-specific blood transfusion and cyclosporin A on cardiac allograft survival and mixed lymphocyte reaction in rats

Park IY, Koh YB, Lee YK

  • KMID: 2324046
  • J Korean Soc Transplant.
  • 1993 Nov;7(1):47-56.
No abstract available.
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Extended Culture of Bone Marrow with Granulocyte Macrophage-Colony Stimulating Factor Generates Immunosuppressive Cells

Na HY, Sohn M, Ryu SH, Choi W, In H, Shin HS, Park CG

Bone marrow-derived dendritic cells (BM-DCs) are generated from bone marrow (BM) cells cultured with granulocyte macrophage-colony stimulating factor (GM-CSF) for a week. In this study we investigated the effect of...
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Species specificity of a novel factor which augments the expression of MHC class I antigens on tumor cell lines

Puri N, Raval A, Saxena RK

  • KMID: 2045609
  • Exp Mol Med.
  • 1997 Jun;29(2):129-132.
A novel factor which augments the expression of major histocompatibility complex I (MHC augmenting factor or MHC-AF) antigens on tumor cell lines, has been isolated from the culture supernatants of...
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Inhibition of Interleukin-1 Signal by Annexin-1 in Phorbol Myristate Acetate Stimulated Lymphocytes

Rhee HJ, Park KK, Na DS, Kim HW

  • KMID: 1550785
  • Korean J Immunol.
  • 1999 Jun;21(2):147-152.
Annexin-1 (ANX1) is a 37 kDa protein that is induced and secreted by glucocorticosteroid hormone. The secreted ANX1 has been believed to exert its function by binding to its putative...
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The Effects of Treponema pallidum on Human Dendritic Cells

Shin JL, Chung KY, Kang JM, Lee TH, Lee MG

Cell mediated immune responses play a prominent role in syphilis, which is caused by Treponema pallidum. The role of dendritic cells (DC) in the syphilitic infection is not well understood...
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Mechanism of Cultured Mouse Mesenchymal Stem Cell-Induced Suppression of Allogeneic Lymphocytes Proliferation

Hong S, Kwon OJ, Kim JA

  • KMID: 2252535
  • Korean J Hematol.
  • 2004 Jun;39(2):86-94.
BACKGROUND: Mesenchymal stem cells (MSC) can be defined by their extensive in vitro self renewal capacity and multi-lineage differentiation potentiality. These cells possess in vitro immunosuppressive properties that appear not...
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Two-Round Mixed Lymphocyte Reaction for Evaluation of the Functional Activities of Anti-PD-1 and Immunomodulators

Kwon M, Choi YJ, Sa M, Park SH, Shin EC

Immune checkpoint inhibitors (ICIs), such as anti-PD-1 and anti-PD-L1 Abs, have shown efficacy for the treatment of various cancers. Although research has actively sought to develop new ICIs and immunomodulators,...
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A Novel Immunomodulatory Mechanism Dependent on Acetylcholine Secreted by Human Bone Marrow-derived Mesenchymal Stem Cells

Yi TG, Cho YK, Lee HJ, Kim J, Jeon MS, Ham DS, Kim WC, Song SU

BACKGROUND AND OBJECTIVES: Mesenchymal stem cells (MSCs) are used to treat autoimmune or inflammatory diseases. Our aim was to determine the immunomodulatory mechanisms elicited by MSCs during inflammation. METHODS AND RESULTS:...
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Immunotherapy for Malignant Melanoma using Dendritic Cells

Lee TH, Cho YH, Lee MG

  • KMID: 1891819
  • Korean J Dermatol.
  • 2006 Feb;44(2):141-148.
BACKGROUND: Malignant melanoma is a potentially lethal cancer that arises from melanocytes present in skin, mucosa, or the epithelial surfaces of eyes and ears, and its incidence has increased substantially....
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Alloimmune and Skin Allograft Responses in 4-1BB (CD137)-deficient Mice

Wolisi G, Srirangam , Vinay DS, Suh JH, Suh HS, Choi BK, Kwon BS

BACKGROUND: The costimulatory molecule 4-1BB, a member of nerve growth factor receptor/tumor necrosis factor (NGFR/TNFR) super family, is involved in cell survival and death. METHODS: In this study, female C57BL/6 (H-2(b))...
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Generation and Qualification of Functionally Active Leukemia-derived DCs from Malignant Blasts in Acute Leukemia

Baek S, Jung CW, Kim MJ, Kim K, Ahn JS, Lee H

BACKGROUND: Dendritic cells (DCs) are increasingly being utilized for anti-cancer immunotherapy. Acute myeloid leukemia (AML) blasts are able to generate leukemia-derived DC. Advances in culture techniques and AML-DC characterization justify...
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Bacterial strains isolated from Jeotgal (salted seafood) induce maturation and cytokine production in mouse bone marrow-derived dendritic cells

Moon SY, Park EJ, Joo HG

  • KMID: 1726743
  • Korean J Vet Res.
  • 2014 Sep;54(3):139-146.
Jeotgal (salted seafood) has been one of major fermented foods in Korea for long time. Although there are many studies about Jeotgal in various aspects of food, its immunological importance...
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Immunological aspects in patients with chronic active hepatitis--cellular immune responses

Park B, Koo J, De Groote

We studied host immune parameters which might be related to the activity and the pathogenetic mechanism of chronic active hepatitis. The subjects consisted of 45 cases with hepatitis B virus...
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Active Immunization Using Dendritic Cells Mixed With Tumor Cells Inhibits The Growth Of Lymphomas

Park J, Suh C, Yang J, Park JS, Park KU, Min YJ, Kim HJ, Kim YH, Kim SH

Dendritic cells (DCs) are potent antigen-presenting cells for the induction and activation of cytotoxic T lymphocytes. We tested whether bone marrow derived DCs are capable of inducing protective immunity against...
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Effect of the Antigenic Differences of Neuroblastoma on the Maturation and Immunoactivity in Dendritic Cells

Jang IK, Choi JE, Kim YJ, Hwang JS, Kim SH, Park JE

  • KMID: 2278333
  • Korean J Pediatr Hematol Oncol.
  • 2005 Apr;12(1):47-54.
PURPOSE: Most of neuroblastoma (NB) patients present with advanced disease, and the survival of patients with advanced stage disease remains poor, despite of aggressive therapy such as high dose chemotherapy...
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The Immune Tolerance Effect of Donor Chimerism Induced by Sublethal dose of Radiation on Allogeneic Organ Transplantation

Kim JA, Hong SY, Choi YS, Kim SH, Kim CC

  • KMID: 2252433
  • Korean J Hematol.
  • 2002 Feb;37(1):46-53.
BACKGROUND: Transplantation of solid organs has been increasing explosively. However, numerous problems remain unsolved, including the requirement for chronic immunosuppressive therapy and the shortage of donor organs. Recently one way...
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Enhancement of Proliferation and Antigen Presentation of Human B Cells in Vitro by K562 Cells Expressing CD40L

Park JY, Yoon SH, Kim EK, Yun SO, Sohn HJ, Kim TG

BACKGROUND: CD40-activated B (CD40-B) cells might be an attractive source of autologous antigen-presenting cells (APCs) for immunotherapy due to the convenience to obtain from peripheral blood and expand in vitro....
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Immunosuppression of xenograft rejection in porcine kidney PK15 cells by porcine IL-18

Choi YS, Kim YK, Shim JH, Kim EM, Kang HS, Yoon DY, Muneta Y, Myung PK

  • KMID: 1098092
  • Exp Mol Med.
  • 2006 Oct;38(5):574-582.
Xenotransplantation, the transplantation of cells, tissues or organs between individuals of different species, would resolve the current shortage of organs, but rejection remains the major hurdle to successful xenotransplantation. In...
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Immunotherapeutic Effects of CTLA4Ig Fusion Protein on Murine EAE and GVHD

Jang SO, Hong SJ, Cho HS, Chung YH

BACKGROUND: CTLA4 (CD152), which is expressed on the surface of T cells following activation, has a much higher affinity for B7 molecules comparing to CD28, and is a negative regulator...
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Immune Tolerance Effect of Immature Dendritic Cells Cultured Using Low-dose GM-CSF

Kim JA, Hong S, Choi YS, Kim CC

  • KMID: 2014032
  • Korean J Hematol.
  • 2003 May;38(2):100-107.
BACKGROUND: Dendritic cells induce tolerance in the immature state besides the function of antigen presenting cells in the mature state. Using this effect, it will be overcome the rejection in...
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