- Effect of Ca2+ channel blockers, external Ca2+ and phospholipase A2 inhibitors on t-butylhydroperoxide-induced lipid peroxidation and toxicity in rat liver slices
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Heo J, Kim GH, Lee KS, Go WU, Ju HJ, Park SK, Song CS, Song GA, Cho M, Yang US, Moon HK, Kim YK
- KMID: 1051573
- Korean J Intern Med.
- 1997 Jun;12(2):193-200.
OBJECTIVES: This study was undertaken to examine the effect of oxidant on lipid peroxidation and lethal cell injury in rat liver slices. METHODS: t-Butylhydroperoxide (t-BHP) was employed as a model... -
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- Effects of prostaglandins on ethanol damage in primary cultured rat hepatocytes
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Yang JM, Choi SW, Kim SS, Sun HS, Park DH, Han SB, Oh GT, Kim WM
- KMID: 759062
- Korean J Intern Med.
- 1998 Feb;13(1):1-9.
OBJECTIVES: Several reports demonstrated that ethanol administration impairs the DNA synthesis in rat hepatocytes. Also, it has been demonstrated that prostaglandin (PG) helps prevent membrane damage by hepatotoxic chemicals. In ... -
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- Effects of Vitamin E Supplementation on Oxidative Stress in Streptozotocin Induced Diabetic Rats: Investigation of Liver and Plasma
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Seven A, Guzel S, Seymen O, Civelek S, Bolayirli , Uncu M, Burcak G
- KMID: 721423
- Yonsei Med J.
- 2004 Aug;45(4):703-710.
- doi: 10.3349/ymj.2004.45.4.703
This experimental study was designed to investigate the effects of vitamin E supplementation, especially on lipid peroxidation and antioxidant status elements3/4namely, glutathione (GSH), CuZn superoxide dismutase (CuZn SOD), and glutathione... -
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- Free radical scavenging and antioxidant enzyme fortifying activities of extracts from Smilax china root
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Lee SE, Ju EM, Kim JH
- KMID: 1457540
- Exp Mol Med.
- 2001 Dec;33(4):263-268.
The extract from Smilax china root has been used as medicinal remedy and reported to retain antimicrobial and antimutagenic acitivities. In this study, a possible presence of antioxidant activity of... -
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- Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice
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Yi J, Xia W, Wu J, Yuan L, Wu J, Tu D, Fang J, Tan Z
- KMID: 1737620
- J Vet Sci.
- 2014 Mar;15(1):141-148.
- doi: 10.4142/jvs.2014.15.1.141
Betulinic acid (BA), a pentacyclic lupane-type triterpene, has a wide range of bioactivities. The main objective of this work was to evaluate the hepatoprotective activity of BA and the potential... -
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- Iron Supplementation in Experimental Hyperthyroidism: Effects on Oxidative Stress in Skeletal Muscle Tissue
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Seymen HO, Civelek S, Seven A, Yigit G, Hatemi H, Burcak G
- KMID: 1734122
- Yonsei Med J.
- 2004 Jun;45(3):413-418.
- doi: 10.3349/ymj.2004.45.3.413
This study was designed to investigate the effects of iron supplementation on the parameters of oxidative stress in the skeletal muscle tissue of hyperthyroidism induced rats. Hyperthyroidism was found to... -
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- Glutathione recycling is attenuated by acute ethanol feeding in rat liver
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Oh SI, Kim CI, Chun HJ, Lee MS, Park SC
- KMID: 1081053
- J Korean Med Sci.
- 1997 Aug;12(4):316-321.
- doi: 10.3346/jkms.1997.12.4.316
The mechanism for ethanol-induced oxidative stress has been disputed because of the controversies on modulation of radical generating and scavenging activities by ethanol. In the present work, we attempted... -
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- Effects of aluminum on the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in the dentate gyrus of D-galactose-treated mice via increasing oxidative stress
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Nam SM, Kim JW, Yoo DY, Kim W, Jung HY, Choi JH, Hwang IK, Seong JK, Yoon YS
- KMID: 2413161
- J Vet Sci.
- 2016 Jun;17(2):127-136.
- doi: 10.4142/jvs.2016.17.2.127
Aluminum (Al) accumulation increases with aging, and long-term exposure to Al is regarded as a risk factor for Alzheimer's disease. In this study, we investigated the effects of Al and/or... -
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- Bisphenol A Impairs Mitochondrial Function in the Liver at Doses below the No Observed Adverse Effect Level
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Moon MK, Kim MJ, Jung IK, Koo YD, Ann HY, Lee KJ, Kim SH, Yoon YC, Cho BJ, Park KS, Jang HC, Park YJ
- KMID: 1421617
- J Korean Med Sci.
- 2012 Jun;27(6):644-652.
- doi: 10.3346/jkms.2012.27.6.644
Bisphenol A (BPA) has been reported to possess hepatic toxicity. We investigated the hypothesis that BPA, below the no observed adverse effect level (NOAEL), can induce hepatic damage and mitochondrial... -
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- Enhancement of aflatoxin B1-induced enzyme altered hepatic foci in rats by treatment with carbon tetrachloride
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Qin G, Ning Y, Su J, Shinozuka , Lotlikar P
- KMID: 755007
- Exp Mol Med.
- 1998 Dec;30(4):186-191.
The effect of carbon tetrachloride (CCl4) on aflatoxin B1 (AFB1)-induced enzyme altered hepatic foci has been examined in young male Fischer rats given AIN-76A diet. A single i.p. dose of... -
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- Aspartate modulates the ethanol-induced oxidative stress and glutathione utilizing enzymes in rat testes.
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Oh SI, Lee MS, Kim CI, Song KY, Park SC
- KMID: 1093597
- Exp Mol Med.
- 2002 Mar;34(1):47-52.
In order to develop a preventive strategy against ethanol-induced oxidative damages on various tissues and organs, we have examined the protective effect of aspartate on the pathogenesis of testes in... -
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- Natural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress
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Whang WK, Park HS, Ham I, Oh M, Namkoong H, Kim HK, Hwang DW, Hur SY, Kim TE, Park YG, Kim JR, Kim JW
- KMID: 1089453
- Exp Mol Med.
- 2005 Oct;37(5):436-446.
Coumarins comprise a group of natural phenolic compounds found in a variety of plant sources. In view of the established low toxicity, relative cheapness, presence in the diet and occurrence... -
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- Phytotherapeutic effects of Echinacea purpurea in gamma-irradiated mice
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Abouelella AM, Shahein YE, Tawfik SS, Zahran AM
- KMID: 1106213
- J Vet Sci.
- 2007 Dec;8(4):341-351.
- doi: 10.4142/jvs.2007.8.4.341
Echinacea (E.) purpurea herb is commonly known as the purple coneflower, red sunflower and rudbeckia. In this paper, we report the curative efficacy of an Echinacea extract in gamma-irradiated mice.... -
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- Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy
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Min HS, Cha JJ, Kim K, Kim JE, Ghee JY, Kim H, Lee JE, Han JY, Jeong LS, Cha DR, Kang YS
- KMID: 2468272
- J Korean Med Sci.
- 2016 Sep;31(9):1403-1412.
- doi: 10.3346/jkms.2016.31.9.1403
The concentration of adenosine in the normal kidney increases markedly during renal hypoxia, ischemia, and inflammation. A recent study reported that an A3 adenosine receptor (A3AR) antagonist attenuated the progression... -
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- Combined Administration of Glutamine and Growth Hormone Synergistically Reduces Bacterial Translocation in Sepsis
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Jung SE, Youn YK, Lim YS, Song HG, Rhee JE, Suh GJ
- KMID: 1099787
- J Korean Med Sci.
- 2003 Feb;18(1):17-22.
- doi: 10.3346/jkms.2003.18.1.17
We investigated the combined effect of glutamine (GLN) and growth hormone (GH) on bacterial translocation (BT) in sepsis. After single intraperitoneal injection of lipopolysaccharide (10 mg/kg), 48 rats were divided... -
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