- New Meroterpenoids from a Penicillium sp. Fungus
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Hwang JY, You MJ, Oh DC, Oh KB, Shin J
- KMID: 2432420
- Nat Prod Sci.
- 2018 Dec;24(4):253-258.
- doi: 10.20307/nps.2018.24.4.253
Two meroterpenoids (1 and 2) along with twelve known compounds (3 – 14) were isolated from the culture broth of a Penicillium sp. fungus collected from Chuja-do, Korea. Based on... -
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- Cytotoxic Lactones from the Pericarps of Litsea japonica
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Ngo QM, Cao TQ, Woo MH, Min BS
- KMID: 2443099
- Nat Prod Sci.
- 2019 Mar;25(1):23-27.
- doi: 10.20307/nps.2019.25.1.23
From the pericarps of Litsea japonica (Thunb.) Jussieu, eighteen butanolide derivatives (1 – 18) were evaluated for their cytotoxic activity against HeLa, HL-60, and MCF-7 cells. Compounds 1 – 9... -
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- Anti-inflammatory Activity of Standardized Fraction from Inula helenium L. via Suppression of NF-κB Pathway in RAW 264.7 Cells
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Chun J, Song K, Kim YS
- KMID: 2443098
- Nat Prod Sci.
- 2019 Mar;25(1):16-22.
- doi: 10.20307/nps.2019.25.1.16
Inula helenium L. is rich source of eudesmane-type sesquiterpene lactones, mainly alantolactone and isoalantolactone, which have the various pharmacological functions. In this study, we examined the inhibitory effects of nitric... -
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- Drug Therapy for Obesity
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Kim KS, Park SW
- KMID: 2270999
- Korean J Obes.
- 2012 Dec;21(4):197-202.
Obesity is associated with a substantial increase in metabolic disorders and various cancers. As weight loss achieved with lifestyle intervention is modest, there is a need for drug treatment. Orlistat, phentermine,... -
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- Anti-Obesity Drugs: A Review about Their Effects and Safety
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Kang JG, Park CY
- KMID: 2281424
- Diabetes Metab J.
- 2012 Feb;36(1):13-25.
- doi: 10.4093/dmj.2012.36.1.13
The current recommendations for the treatment of obese people include increased physical activity and reduced calories intake. When the behavioral approach is not sufficient, a pharmacologic treatment is recommended. In... -
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- Antifungal Activity of Securinine against Some Plant Pathogenic Fungi
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Singh AK, Pandey MB, Singh S, Singh AK, Singh UP
- KMID: 2411403
- Mycobiology.
- 2008 Jun;36(2):99-101.
The alkaloid securinine was assessed against spore germination of some plant pathogenic and saprophytic fungi (Alternaria alternata, Alternaria brassicae, Alternaria brassicicola, Curvularia lunata, Curvularia maculans, Curvularia pallenscens, Colletotrichum musae, Colletotrichum... -
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- Behavioral Intervention and Anti-Obesity Drug Therapy
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Kim MK
- KMID: 2267840
- Korean J Med.
- 2013 May;84(5):624-628.
Obesity is associated with a reduction in life expectancy and an increase in mortality from cardiovascular diseases, cancer, and other causes. The U.S. Preventive Service Task Force (USPSTF) recommends screening... -
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- Stroke Update 2011: New Antithrombotics
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Seo KD, Lee KY
- KMID: 2288709
- Korean J Stroke.
- 2012 Aug;14(2):62-66.
Several new antithrombotic drugs have been developed and approved to use in clinical practice recently. Dabigatran, a direct thrombin inhibitor, and rivaroxaban, a factor Xa inhibitor, have been approved in... -
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- Inhibitory Effects of Corni Fructus Extract on Angiogenesis and Adipogenesis
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Hwang JH, Kim JD
- KMID: 2389108
- Korean J Physiol Pharmacol.
- 2011 Feb;15(1):43-51.
Natural products in Chonnam, Korea were screened via anti-angiogenesis experiments, and 1 candidate product was identified, Corni fructus, which exerted dose-dependent inhibitory effects against angiogenesis, adipogenesis, and cell adhesion. C.... -
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- Pharmacotherapy for obesity
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Kim KK
- KMID: 2190426
- J Korean Med Assoc.
- 2011 Apr;54(4):409-418.
- doi: 10.5124/jkma.2011.54.4.409
Due to its serious comorbidities and high prevalence, obesity is one of the heaviest burdens for public health. Although diet, exercise and behavioral modification are the first-line treatment for obesity,... -
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- Alternaria and Alternariol Mycotoxins Affect Production of Allergic Inflammatory Cytokines in MLE12 and RAW264.7 Cells
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- KMID: 2299453
- Korean J Asthma Allergy Clin Immunol.
- 2012 Dec;32(4):231-238.
BACKGROUND: Alternaria and their secondary metabolites, alternariol mycotoxins, may cause respiratory symptoms and asthma. Moreover, microbial compounds, such as bacterial endotoxins, act as potential contributors in such situations. Alveolar epithelial... -
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- Acute toxicity of cyclooxygenase-2 inhibitor rofecoxib as a radiosensitizer for concurrent chemoradiation in the treatment of uterine cervical cancer
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Jung YW, Lee SH, Paek JH, Nam EJ, Kim SW, Kim JH, Kim JW, Kim YT
- KMID: 2173447
- J Gynecol Oncol.
- 2009 Sep;20(3):151-157.
- doi: 10.3802/jgo.2009.20.3.151
OBJECTIVE: To evaluate the acute toxicity of rofecoxib during concurrent use with cisplatin-based chemoradiotherapy (CCRT) in patients with cervical cancer. METHODS: We evaluated 67 FIGO stage IB2-IVA cervical cancer patients... -
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- Kinetic Changes of COX-2 Expression during Reperfusion Period after Ischemic Preconditioning Play a Role in Protection Against Ischemic Damage in Rat Brain
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Kang YJ, Park MK, Lee HS, Choi HC, Lee KY, Kim HJ, Seo HG, Lee JH, Chang KC
- KMID: 1486110
- Korean J Physiol Pharmacol.
- 2008 Oct;12(5):275-280.
- doi: 10.4196/kjpp.2008.12.5.275
A brief ischemic insult induces significant protection against subsequent massive ischemic events. The molecular mechanisms known as preconditioning (PC)-induced ischemic tolerance are not completely understood. We investigated whether kinetic changes... -
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- The effect of angiogenic factors with HA/PCL scaffold containing matrigel in a rat calvarial defect model
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Kim SE, Shim KM, Choi SH, Kang SS
- KMID: 1498931
- J Biomed Res.
- 2013 Jun;14(2):118-124.
The current study was conducted in order to investigate bone formation using matrigel and angiogenic factors with HA and poly epsilon-caprolactone (HA/PCL) in a rat calvarial defect model. Calvarial defect... -
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- The Effects of Non-surgical Weight Reduction on Daytime Sleepiness and Fatigue in Patients with Obstructive Sleep Anpea
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Kang SG, Kim SH, Park SJ, Kim HN, Park YJ, Song SW
- KMID: 2270957
- Korean J Obes.
- 2011 Dec;20(4):177-184.
BACKGROUND: Among the many complications caused by obesity, the most common respiratory complication is upper respiratory obstruction during sleep caused by snoring. Long term snoring may lead to obstructive sleep... -
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- The Combined Effects of Ginkgo Biloba Extracts and Aspirin on Viability of SK-N-MC, Neuroblastoma Cell Line in Hypoxia and Reperfusion Condition
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Moon SH, Lee YJ, Park SY, Song KY, Kong MH, Kim JH
- KMID: 1442687
- J Korean Neurosurg Soc.
- 2011 Jan;49(1):13-19.
- doi: 10.3340/jkns.2011.49.1.13
OBJECTIVE: The purpose of this study is to investigate the combined effects of ginkgo biloba extract, ginkgolide A and B and aspirin on SK-N-MC, human neuroblastoma cell viability and mRNA... -
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- Pancreatic lipase inhibitory activity of taraxacum officinale in vitro and in vivo
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Zhang J, Kang MJ, Kim MJ, Kim ME, Song JH, Lee YM, Kim JI
- KMID: 2139192
- Nutr Res Pract.
- 2008 Dec;2(4):200-203.
- doi: 10.4162/nrp.2008.2.4.200
Obesity has become a worldwide health problem. Orlistat, an inhibitor of pancreatic lipase, is currently approved as an anti-obesity drug. However, gastrointestinal side effects caused by Orlistat may limit its... -
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- A Case of Acute Cholestatic Hepatitis Associated with Orlistat
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Kim DH, Lee EH, Hwang JC, Jeung JH, Kim DH, Cheong JY, Cho SW, Kim YB
- KMID: 863103
- Korean J Hepatol.
- 2002 Sep;8(3):317-320.
Orlistat(Xenical(R), Roche) is considered a safe and effective drug to treat obesity by reduced absorption of 30% digested fat. To date, no serious adverse effects affecting the liver have... -
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- A Case of Complete Regression of Hepatocellular Carcinoma during Administration of COX-2 Inhibitor
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Song HJ, Kim YS, Han CH, Jang JY, Kim JH, Cheon YK, Kim YS, Moon JH, Cho YD, Shim CS, Kwon KH, Kim BS
- KMID: 760678
- Korean J Hepatol.
- 2006 Sep;12(3):449-454.
Overexpression of cyclooxygenase-2 (COX-2) has been associated with hepatocarcinogenesis. Inhibitors of COX-2 have proapoptotic and antiproliferative effects on malignant tumors and inhibit tumor invasion to the surrounding tissues. We report... -
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- Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells
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Yun BR, Lee MJ, Kim JH, Kim IH, Yu GR, Kim DG
- KMID: 994402
- Exp Mol Med.
- 2010 Nov;42(11):787-797.
- doi: 10.3858/emm.2010.42.11.082
Cholangiocarcinoma (CC) is a chemoresistant intrahepatic bile duct carcinoma with a poor prognosis. The aims of this study were to identify molecular pathways that enhance sesquiterpene lactone parthenolide (PTL)-induced anticancer... -
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