- Working with laboratory rodents in Spain: a survey on welfare and wellbeing
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Goñi-Balentziaga O, Ortega-Saez I, Vila S, Azkona G
- KMID: 2521035
- Lab Anim Res.
- 2021 Sep;37(3):203-212.
- doi: 10.1186/s42826-021-00098-w
Background: Replacement, reduction and refinement, the 3R principles, provide a framework to minimize the use and suffering of animals in science. In this context, we aimed to determine the actual... -
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- Experimental animal models for diabetes and its related complications—a review
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Kottaisamy CPD, Raj DS, Kumar VP, Sankaran U
- KMID: 2521030
- Lab Anim Res.
- 2021 Sep;37(3):127-140.
- doi: 10.1186/s42826-021-00101-4
Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one of the fastest growing public health problems in the world. It is characterized by hyperglycemia, a condition... -
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- Correction to: Lipopolysaccharides of Fusobacterium nucleatum and Porphyromonas gingivalis increase RANKLexpressing neutrophils in air pouches of mice
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Kim AR, Lim YK, Kook JK, Bak EJ, Yoo YJ
- KMID: 2521041
- Lab Anim Res.
- 2021 Sep;37(3):264-265.
- doi: 10.1186/s42826-021-00099-9
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- A comparative review on heart ion channels, action potentials and electrocardiogram in rodents and human: extrapolation of experimental insights to clinic
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Joukar S
- KMID: 2521031
- Lab Anim Res.
- 2021 Sep;37(3):141-155.
- doi: 10.1186/s42826-021-00102-3
Electrocardiogram (ECG) is a non-invasive valuable diagnostic tool that is used in clinics for investigation and monitoring of heart electrical rhythm/conduction, ischemia/injury of heart, electrolyte disturbances and agents/drugs induced cardiac... -
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- Comparison of intrinsic exercise capacity and response to acute exercise in ICR (Institute of Cancer Research) mice derived from three different lineages
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Hwang DJ, Kwon KC, Choi DH, Song HK, Kim KS, Jung YS, Hwang DY, Cho JY
- KMID: 2521037
- Lab Anim Res.
- 2021 Sep;37(3):223-232.
- doi: 10.1186/s42826-021-00094-0
Background: As a laboratory animal resource, the ICR mouse is commonly used in a variety of research fields. However, information on differences in exercise-related characteristics in ICR mice derived from... -
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- Establishment of particulate matterinduced lung injury model in mouse
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Park SY, An KS, Lee B, Kang JH, Jung HJ, Kim MW, Ryu HY, Shim KS, Nam KT, Yoon YS, Oh SH
- KMID: 2521040
- Lab Anim Res.
- 2021 Sep;37(3):252-263.
- doi: 10.1186/s42826-021-00097-x
Background: Particulate matter (PM) is one of the principal causes of human respiratory disabilities resulting from air pollution. Animal models have been applied to discover preventive and therapeutic drugs for... -
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- Transgenic fluorescent zebrafish lines that have revolutionized biomedical research
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Choe CP, Choi SY, Kee Y, Kim MJ, Kim SH, Lee Y, Park HC, Ro H
- KMID: 2521032
- Lab Anim Res.
- 2021 Sep;37(3):156-184.
- doi: 10.1186/s42826-021-00103-2
Since its debut in the biomedical research fields in 1981, zebrafish have been used as a vertebrate model organism in more than 40,000 biomedical research studies. Especially useful are zebrafish... -
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- Increases in GFAP immunoreactive astrocytes in the cerebellar molecular layer of young adult CBA/J mice
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Tyszkiewicz C, Pardo ID, Ritenour HN, Liu CN, Somps C
- KMID: 2521038
- Lab Anim Res.
- 2021 Sep;37(3):233-240.
- doi: 10.1186/s42826-021-00100-5
Background: CBA/J mice are standard experimental animals in auditory studies, and age-related changes in auditory pathways are well documented. However, changes in locomotion-related brain regions have not been systematically explored. Results:... -
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- Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor
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Beladiya JV, Mehta AA
- KMID: 2521034
- Lab Anim Res.
- 2021 Sep;37(3):193-202.
- doi: 10.1186/s42826-021-00093-1
Background: The aim of study was to evaluate the single oral dose and 28 day repeated oral administration toxicity profile of the synthetic compound Gαq-RGS2 signaling inhibitor, (1-(5-chloro-2-hydroxyphenyl)-3-(4-(trifluoromethyl)phenyl)-1 H-1,2,4-triazol-5(4 H)-one)... -
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- Induction of colorectal carcinogenesis in the C57BL/6J and A/J mouse strains with a reduced DSS dose in the AOM/DSS model
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Arnesen H, Müller MHB, Aleksandersen M, Østby GC, Carlsen H, Paulsen JE, Boysen P
- KMID: 2521036
- Lab Anim Res.
- 2021 Sep;37(3):213-222.
- doi: 10.1186/s42826-021-00096-y
Background: Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide and thus mouse models of CRC are of significant value to study the pathogenesis. The Azoxymethane/Dextran sulfate... -
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- Zebrafish toxicological screening could aid Leishmaniosis drug discovery
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Fukushima HCS, Bailone RL, Corrêa T, Janke H, Aguiar LKD, Setti PG, Borra RC
- KMID: 2521039
- Lab Anim Res.
- 2021 Sep;37(3):241-251.
- doi: 10.1186/s42826-021-00104-1
Background: Recently a screen from a library of 1.8 million compounds identified in vitro a potent activity of the 2-aminobenzimidazoles series against Leishmania infantum, the etiological agent responsible by over... -
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- Hypothermic treatment reduces matrix metalloproteinase-9 expression and damage in the liver following asphyxial cardiac arrest in rats
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Kim D, Kim B, Sim H, Lee TK, Tae HJ, Lee JC, Park JH, Cho JH, Won MH, Park Y, Ahn JH
- KMID: 2521033
- Lab Anim Res.
- 2021 Sep;37(3):185-192.
- doi: 10.1186/s42826-021-00095-z
Background: Hypothermic treatment is known to protect organs against cardiac arrest (CA) and improves survival rate. However, few studies have evaluated the effects of hypothermia on CA-induced liver damages. This... -
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