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Full-Endoscopic Transcervical Ventral Decompression for Pathologies of Craniovertebral Junction: Case Series

Ohara Y, Nakajima Y, Kimura T, Kikuchi N, Sagiuchi T

Odontoidectomy is very effective for the decompression of the ventral craniovertebral junction (CVJ). Various approaches are available for the direct ventral decompression of the CVJ. Because there are many disadvantages...
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Efficacy of Androgen Deprivation Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Docetaxel-Based Chemotherapy

Min K, Chung JW, Ha YS, Lee JN, Kim BS, Kim HT, Kim TH, Yoo ES, Kwon TG, Chung SK, Tanaka M, Egawa S, Kimura T, Choi SH

PURPOSE: The purpose of this study was to determine the comparative effectiveness of androgen deprivation therapy (ADT) combined with docetaxel (DTX)-based chemotherapy in Korean and Japanese castration-resistant prostate cancer (CRPC)...
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Portal bifurcation reconstruction using own hepatic vein grafts due to portal vein anomaly of the living donor for the patient with portal vein thrombosis

Umemura A, Nitta H, Takahara T, Hasegawa Y, Katagiri H, Kanno S, Kobayashi M, Ando T, Kimura T, Sasaki A

A 57-year-old Japanese female was considered for living donor liver transplantation (LDLT) due to end-stage liver cirrhosis caused by primary biliary cholangitis with portal vein thrombosis (PVT) formation. A 26-year-old...
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Sodium-glucose Co-transporters-2 Inhibitors and Heart Failure: State of the Art Review and Future Potentials

Kato ET, Kimura T

Heart failure (HF) and type 2 diabetes mellitus (T2DM) are progressive chronic diseases that increase the risk of mortality and have worse outcomes when they coexist. There has been a...
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External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk

van Kammen MS, Greving JP, Kuroda S, Kashiwazaki D, Morita A, Shiokawa Y, Kimura T, Cognard C, Januel AC, Lindgren A, Koivisto T, Jääskeläinen JE, Ronkainen , Pyysalo L, Öhman J, Rahi M, Kuhmonen J, Rinne J, Leemans EL, Majoie CB, Vandertop , Verbaan D, Roos YB, van den Berg R, Boogaarts , Moudrous W, van den Wijngaard IR, Hove LT, Teo M, St George , Hackenberg KAM, Abdulazim , Etminan N, Rinkel GJ, Vergouwen

BACKGROUND AND PURPOSE: Prediction of intracranial aneurysm growth risk can assist physicians in planning of follow-up imaging of conservatively managed unruptured intracranial aneurysms. We therefore aimed to externally validate the...
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Two Manganese Peroxidases and a Laccase of Trametes polyzona KU-RNW027 with Novel Properties for Dye and Pharmaceutical Product Degradation in Redox Mediator-Free System

Lueangjaroenkit P, Teerapatsakul C, Sakka K, Sakka M, Kimura T, Kunitake E, Chitradon

Two manganese peroxidases (MnPs), MnP1 and MnP2, and a laccase, Lac1, were purified from Trametes polyzona KU-RNW027. Both MnPs showed high stability in organic solvents which triggered their activities. Metal...
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A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation

Mori S, Tomita T, Fujimura K, Asano H, Ogawa T, Yamasaki T, Kondo T, Kono T, Tozawa K, Oshima T, Fukui H, Kimura T, Watari J, Miwa H

  • KMID: 2460486
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):563-575.
  • doi: 10.5056/jnm18194
BACKGROUND/AIMS: Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic...
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Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein

Aizawa H, Yamashita , Kato H, Kimura T, Kwak S

BACKGROUND AND PURPOSE: Disruption of nucleoporins has been reported in the motor neurons of patients with sporadic amyotrophic lateral sclerosis (sALS). However, the precise changes in the morphology of nucleoporins...
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Long-term prognosis of Japanese patients with biologic-naïve Crohn’s disease treated with anti-tumor necrosis factor-α antibodies

Moroi R, Endo K, Yamamoto K, Naito T, Onodera M, Kuroha M, Kanazawa Y, Kimura T, Kakuta Y, Masamune A, Kinouchi Y, Shimosegawa T

BACKGROUND/AIMS: Few reports have described the long-term treatment outcomes of the anti-tumor necrosis factor-α antibody for Japanese Crohn’s disease (CD) patients. The aim of this study was to evaluate them...
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Dembo polymerase chain reaction technique for detection of bovine abortion, diarrhea, and respiratory disease complex infectious agents in potential vectors and reservoirs

Rahpaya SS, Tsuchiaka , Kishimoto , Oba M, Katayama Y, Nunomura Y, Kokawa S, Kimura T, Kobayashi , Kirino Y, Okabayashi T, Nonaka N, Mekata H, Aoki H, Shiokawa M, Umetsu M, Morita T, Hasebe A, Otsu K, Asai T, Yamaguchi , Makino S, Murata Y, Abi AJ, Omatsu T, Mizutani T

Bovine abortion, diarrhea, and respiratory disease complexes, caused by infectious agents, result in high and significant economic losses for the cattle industry. These pathogens are likely transmitted by various vectors...
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Twin Rectal Tonsils Mimicking Carcinoid or Mucosa-Associated Lymphoid Tissue Lymphoma

Takehara M, Muguruma N, Kitamura S, Kimura T, Okamoto K, Miyamoto H, Bando Y, Takayama T

The rectal tonsil is a rare polypoid lesion exclusively found in the rectum and is considered a reactive proliferation of the lymphoid tissue. Although this lesion is benign, we recommend...
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Impact of histological subtype on survival in patients with locally advanced cervical cancer that were treated with definitive radiotherapy: adenocarcinoma/adenosquamous carcinoma versus squamous cell carcinoma

Yokoi E, Mabuchi S, Takahashi , Matsumoto , Kuroda H, Kozasa K, Kimura T

OBJECTIVE: To compare the survival outcomes of patients with cervical squamous cell carcinoma (SCC) and adenocarcinoma/adenosquamous carcinoma (AC/ASC) among patients with locally advanced cervical cancer that were treated with definitive...
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Chemoradiotherapy followed by consolidation chemotherapy involving paclitaxel and carboplatin and in FIGO stage IIIB/IVA cervical cancer patients

Mabuchi S, Isohashi F, Okazawa M, Kitada F, Maruoka S, Ogawa K, Kimura T

OBJECTIVE: To evaluate the efficacy and toxicity of paclitaxel plus carboplatin (TC)-based concurrent chemoradiotherapy (CCRT) followed by consolidation chemotherapy in the International Federation of Gynecology and Obstetrics (FIGO) stage IIIB/IVA...
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The impacts of computer adaptive testing from a variety of perspectives

Kimura T

Computer adaptive testing (CAT) is a kind of tailored testing, in that it is a form of computer-based testing that is adaptive to each test-taker's ability level. In this review,...
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Compression Myelopathy due to Proliferative Changes around C2 Pars Defects without Instability

Kimura T, Sakai T, Tezuka F, Abe M, Yamashita , Takata Y, Higashino , Sairyo K

We report a case with compression myelopathy due to proliferative changes around the C2 pars defects without instability. A 69-year-old man presented with progressive clumsy hands and spastic gait. Plain...
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Clear cell carcinoma of the ovary: molecular insights and future therapeutic perspectives

Mabuchi S, Sugiyama T, Kimura T

Clear cell carcinoma (CCC) of the ovary is known to show poorer sensitivity to chemotherapeutic agents and to be associated with a worse prognosis than the more common serous adenocarcinoma...
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Circumferential Spinal Cord Decompression through a Single Posterior Approach with Microendoscopy for Thoracic and Thoracolumbar Ossification of the Posterior Longitudinal Ligament

Seki S, Mine H, Kawaguchi , Makino H, Kimura T

Thoracic and thoracolumbar ossification of the posterior longitudinal ligament (OPLL) can be difficult to treat due to the anatomical position. The purpose of this study was to report the significance...
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Endoscopic Management of Nonvariceal Upper Gastrointestinal Bleeding: State of the Art

Muguruma N, Kitamura S, Kimura T, Miyamoto H, Takayama T

Nonvariceal upper gastrointestinal (GI) bleeding is one of the most common reasons for hospitalization and a major cause of morbidity and mortality worldwide. Recently developed endoscopic devices and supporting apparatuses...
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Clinical implication of surgically treated early-stage cervical cancer with multiple high-risk factors

Matsuo K, Mabuchi S, Okazawa M, Kawano M, Kuroda H, Kamiura S, Kimura T

OBJECTIVE: Presence of high-risk factor in cervical cancer is known to be associated with decreased survival outcomes. However, the significance of multiple high-risk factors in early-stage cervical cancer related to...
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Placenta percreta with a vaginal fistula after successful management by uterine transverse fundal incision and subsequent cesarean hysterectomy

Matsuzaki , Matsuzaki , Ueda Y, Egawa-Takata T, Mimura K, Kanagawa T, Morii E, Kimura T

Placenta previa presents a highest risk to pregnancy, and placenta accreta is the most serious. Placenta accreta requires cesarean delivery and often results in massive obstetric hemorrhage and higher maternal...
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