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Biomarker for recurrent immunoglobulin A nephropathy in kidney allografts: promising but still a long way to go

Chung BH

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The removal capacity of asymmetric cellulose triacetate during post-dilution online hemodiafiltration

Santos A, Macías N, Cruzado L, Vega A

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Does a slight change in serum creatinine matter in coronavirus disease 2019 (COVID-19) patients?

Komaru Y, Doi K

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Extracellular vesicles in kidneys and their clinical potential in renal diseases

Lee SA, Choi C, Yoo TH

Extracellular vesicles (EVs), such as exosomes and microvesicles, are cell-derived lipid bilayer membrane particles, which deliver information from host cells to recipient cells. EVs are involved in various biological processes...
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Clinical significance of serum galactose-deficient immunoglobulin A1 for detection of recurrent immunoglobulin A nephropathy in kidney transplant recipients

Park WY, Kim Y, Paek JH, Jin K, Han S

Background: Recurrent glomerulonephritis (GN) is a common cause of allograft loss in kidney transplantation (KT), the most frequent of which is immunoglobulin A (IgA) nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) plays...
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Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies

Verma S, Singh P, Khurana S, Ganguly NK, Kukreti R, Saso L, Rana DS, Taneja V, Bhargava V

Moderate levels of endogenous reactive oxygen species (ROS) are important for various cellular activities, but high levels lead to toxicity and are associated with various diseases. Levels of ROS are...
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Acute kidney injury and mortality in coronavirus disease 2019: results from a cohort study of 1,280 patients

Chebotareva N, Berns S, Berns A, Androsova T, Lebedeva M, Moiseev S

Background: The development of acute kidney injury (AKI) in patients with coronavirus disease 2019 (COVID-19) is associated with a high risk of death. Published data demonstrate the possibility of severe...
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Effects of residential greenness on clinical outcomes of patients with chronic kidney disease: a large-scale observation study

Park JY, Jung J, Kim YC, Lee H, Kim E, Kim YS, Kim H, Lee JP

Background: As industrialization and urbanization are accelerating, the distribution of green areas is decreasing, particularly in developing countries. Since the 2000s, the effects of surrounding greenness on self-perceived health, including...
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Manifestation of rs1888747 polymorphisms in the FRMD3 gene in diabetic kidney disease and diabetic retinopathy in type 2 diabetes patients

Kreepala C, Panpruang P, Yodprom R, Piyajarawong T, Wattanavaekin K, Danjittrong T, Phuthomdee S

Background: FRMD3 polymorphisms has suggested that they could be an alternative test to differentiate diabetic nephropathy (DN) from nondiabetic renal disease (NDRD) in type 2 diabetes mellitus (DM) patients. This...
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Changes in metabolic parameters and adverse kidney and cardiovascular events during glomerulonephritis and renal vasculitis treatment in patients with and without diabetes mellitus

Lim CC, Choo JCJ, Tan HZ, Mok IYJ, Chin YM, Chan CM, Woo KT

Background: Cardiovascular disease causes significant morbidity and mortality in patients with glomerulonephritis, which is increasingly diagnosed in older individuals who may have diabetes mellitus (DM). We evaluated the impact of...
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Causal effect of alcohol use on the risk of end-stage kidney disease and related comorbidities: a Mendelian randomization study

Park S, Lee S, Kim Y, Lee Y, Kang MW, Kim K, Kim YC, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Kim YS, Kim DK

Background: An inverse observational association between alcohol use and the risk of chronic kidney disease (CKD) or end-stage kidney disease (ESKD) has been reported. The causal effect of alcohol use...
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Twenty-four-hour serum creatinine variation is associated with poor outcome in the novel coronavirus disease 2019 (COVID-19) patients

Alfano G, Ferrari A, Fontana F, Mori G, Ligabue G, Giovanella S, Magistroni R, Meschiari M, Franceschini E, Menozzi M, Cuomo G, Orlando G, Santoro A, Di Gaetano M, Puzzolante C, Carli F, Bedini A, Milic J, Mussini C, Cappelli G, Guaraldi G, for the Modena Covid-19 Working Group (MoCo19)

Background: The development of acute kidney injury (AKI) in patients with coronavirus disease 2019 (COVID-19) is associated with a high risk of death. Published data demonstrate the possibility of severe...
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Age, diabetes mellitus, and dialysis modality are associated with risk of poor muscle strength and physical function in hemodialysis and peritoneal dialysis patients

Silva MZC, Antonio KJ, Reis JMS, Alves LS, Caramori JCT, Vogt BP

Background: Due to the poor outcomes associated with the impairment of physical function and muscle strength in patients on maintenance dialysis, it is important to understand the factors that may...
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Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome

Kim K, Baek E, Go S, Son HE, Ryu JY, Yi Y, Jeong JC, Kim S, Chin HJ

Backgrounds: Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) or eGFR slope over 2 to 3 years have been proposed for...
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Fabry disease exacerbates renal interstitial fibrosis after unilateral ureteral obstruction via impaired autophagy and enhanced apoptosis

Chung S, Son M, Chae Y, Oh S, Koh ES, Kim YK, Shin SJ, Park CW, Jung SC, Kim HS

Background: Fabry disease is a rare X-linked genetic lysosomal disorder caused by mutations in the GLA gene encoding alpha-galactosidase A. Despite some data showing that profibrotic and proinflammatory cytokines and...
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