Kidney Res Clin Pract.
2021 Jun;40(2):263-271. 10.23876/j.krcp.20.190.
Manifestation of rs1888747 polymorphisms in the FRMD3 gene in diabetic kidney disease and diabetic retinopathy in type 2 diabetes patients
- Affiliations
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- 1Nephrology Unit, School of Internal Medicine, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand
- 2Department of Internal Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand
- 3Department of Ophthalmology, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand
- 4Department of General Medical Services, Sakaeo Crown Prince Hospital, Nakhon Nayok, Thailand
- 5Department of Anesthesiology, Chulabhorn Hospital, Bangkok, Thailand
- 6Department of Clinical Biostatistics, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, Pak Kret, Thailand
- KMID: 2520042
- DOI: http://doi.org/10.23876/j.krcp.20.190
Abstract
- Background
FRMD3 polymorphisms has suggested that they could be an alternative test to differentiate diabetic nephropathy (DN) from nondiabetic renal disease (NDRD) in type 2 diabetes mellitus (DM) patients. This study was performed to investigate the relationship between the FRMD3 gene and clinical characteristics of DN.
Methods
Patients who already had renal pathologic results were tested for FRMD3 polymorphisms. The subjects were classified into three groups; DN with diabetic retinopathy (DR), DN without DR, and DM with NDRD. FRMD3 polymorphisms were analyzed in each group.
Results
The prevalence of GG, CG, and CC was 44.4%, 42.2%, and 13.3% respectively. There was no significant difference in clinical parameters, which consisted of disease duration, proteinuria, and complications in DN with or without DR and DM with NDRD. The G allele was mainly found in DN with DR patients (50.8%) whereas the C allele was found in DM with NDRD patients (43.5%) (p = 0.02). There was a significant association between the CC genotype in NDRD when compared to GG (p = 0.001). In addition, the C allele was 2.10-fold more often associated with NDRD than the G allele (p = 0.03). The CC genotype was correlated with risk for NDRD than the GG and GC genotypes, with odds ratios of 6.89 and 4.91, respectively (p = 0.02).
Conclusion
C allele presentation, especially homozygous CC, was associated with NDRD pathology in patients with overt proteinuria. Hence, kidney biopsy is suggested in those with the C allele or homozygous CC genotype, regardless of retinopathy manifestations.
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