- The molecular mechanism for nuclear transport and its application
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Kim YH, Han ME, Oh SO
- KMID: 2451231
- Anat Cell Biol.
- 2017 Jun;50(2):77-85.
- doi: 10.5115/acb.2017.50.2.77
Transportation between the cytoplasm and the nucleoplasm is critical for many physiological and pathophysiological processes including gene expression, signal transduction, and oncogenesis. So, the molecular mechanism for the transportation needs... -
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- Role of HIF1α Regulatory Factors in Stem Cells
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Lee HJ, Jung YH, Choi GE, Kim JS, Chae CW, Han HJ
- KMID: 2447220
- Int J Stem Cells.
- 2019 Mar;12(1):8-20.
- doi: 10.15283/ijsc18109
Hypoxia-inducible factor 1 (HIF1) is a master transcription factor that induces the transcription of genes involved in the metabolism and behavior of stem cells. HIF1-mediated adaptation to hypoxia is required... -
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- Deletion of the Importin-alpha Gene in the Breast Cancer Cell
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Song BJ, Kim CS, Jin MO, Kim DH, Moon YH, Kim IS, Oh ST, Chung SS, Lee JH, Song YT
- KMID: 2095638
- J Korean Surg Soc.
- 1999 Jun;56(Suppl):947-956.
BACKGROUND: BRCA1 (breast-cancer gene 1) is a tumor suppressor gene that accounts for nearly all families of both early onset breast and ovarian cancer and about 45% of families with... -
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- Development of Monoclonal Antibodies Against Human IRF-5 and Their Use in Identifying the Binding of IRF-5 to Nuclear Import Proteins Karyopherin-alpha1 and -beta1
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Yeon SI, Youn JH, Lim MH, Lee HJ, Kim YM, Choi JE, Lee JM, Shin JS
- KMID: 1782953
- Yonsei Med J.
- 2008 Dec;49(6):1023-1031.
- doi: 10.3349/ymj.2008.49.6.1023
PURPOSE: IRF-5 is a direct transducer of virus-mediated and TLR-mediated signaling pathways for the expression of cytokines and chemokines which form homodimers or heterodimers with IRF-7. However, direct IRF-5-specific monoclonal... -
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- Survive or thrive: tradeoff strategy for cellular senescence
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Park SC
- KMID: 2386962
- Exp Mol Med.
- 2017 Jun;49(6):e342.
- doi: 10.1038/emm.2017.94
Aging-dependent cellular behaviors toward extrinsic stress are characterized by the confined localization of certain molecules to either nuclear or perinuclear regions. Although most growth factors can activate downstream signaling in... -
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