- HLA-restricted and Antigen-specific CD8+ T Cell Responses by K562 Cells Expressing HLA-A*0201
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Yun SO, Sohn HJ, Yoon SH, Choi HB, Kim TG
- KMID: 1513149
- Immune Netw.
- 2006 Dec;6(4):179-184.
- doi: 10.4110/in.2006.6.4.179
BACKGROUND: Identification of antigen-specific T cells has yielded valuable information on pathologic process and the disease state. Assays for quantification of inflammatory cytokines or lytic-granule molecules have been generally used... -
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- Enhancement of Proliferation and Antigen Presentation of Human B Cells in Vitro by K562 Cells Expressing CD40L
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Park JY, Yoon SH, Kim EK, Yun SO, Sohn HJ, Kim TG
- KMID: 2150630
- Immune Netw.
- 2007 Jun;7(2):80-86.
- doi: 10.4110/in.2007.7.2.80
BACKGROUND: CD40-activated B (CD40-B) cells might be an attractive source of autologous antigen-presenting cells (APCs) for immunotherapy due to the convenience to obtain from peripheral blood and expand in vitro.... -
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- Selective Expansion of Natural Killer Cells from Peripheral Blood Mononuclear Cells by K562 Cell Line and IL-2
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Cho D, Shin SW, Park JS, Kang HK, Kim SK, Pham TN, Zhu XW, Shin MG, Suh SP, Ryang DW, Nam JH, Kim YJ, Lee JJ
- KMID: 2252322
- Korean J Hematol.
- 2006 Mar;41(1):8-15.
- doi: 10.5045/kjh.2006.41.1.8
BACKGROUND: Several attempts have been made to expand human NK cells from peripheral blood mononuclear cells (PBMCs). This study examined the selective expansion of NK cells using interleukin 2 (IL-2)... -
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- Role of Ras/ERK-dependent pathway in the erythroid differentiation of K562 cells
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Kang CD, Do IR, Kim KW, Ahn BK, Kim SH, Chung BS, Jhun BH, Yoo MA
- KMID: 1029935
- Exp Mol Med.
- 1999 Jun;31(2):76-82.
The chronic myelogenous leukemic K562 cell line carrying Bcr-Abl tyrosine kinase is considered as pluripotent hematopoietic progenitor cells expressing markers for erythroid, granulocytic, monocytic, and megakaryocytic lineages. Here we investigated the signaling modulations... -
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- The Expression of Hydroxyurea Induced Apoptosis Associated Proteins on Chronic Myelogenous Leukemic K562 Cells
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Lee YJ, Park DS, Cho JH
- KMID: 2089662
- Korean J Clin Pathol.
- 2001 Apr;21(2):98-103.
BACKGROUND: Hydroxyurea is used to decrease leukocyte count effectively in chronic myelogenous leukemia. We found that hydroxyurea induced apoptosis on the K562 cells via externalization of phosphatidylserine, activation of some... -
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- Arsenic Trioxide Induces Erythroid Differentiation and Apoptosis of K562 Human Leukemia Cells through the Down-Regulation of Bcl-2
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You YK, Cheong HJ, Won JH, Kim SJ, Bae SB, Kim CK, Lee NS, Lee KT, Park SK, Hong DS, Park HS
- KMID: 2252343
- Korean J Hematol.
- 2005 Jun;40(2):93-100.
- doi: 10.5045/kjh.2005.40.2.93
BACKGROUND: Arsenic trioxide (As2O3) has been identified as an effective drug for the treatment of acute promyelocytic leukemia (APL). However, the role of As2O3 during the erythroid differentiation of human... -
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- Study of Hydroxyurea Induced Caspase Activities in Chronic Myelogenous Leukemic Cell Line, K562 cells
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Lee YJ, Park RK, So HS, Park JS, Cho JH, Choi SI
- KMID: 2225957
- Korean J Clin Pathol.
- 2000 Oct;20(5):435-441.
BACKGROUND: Chronic myelogenous leukemia is a chronic myeloproliferative disorder characterized by leukocytosis with myeloid elements at all stages of differentiation, t(9;22)(q34;q11) and bcr/abl rearrangement. We studied hydroxyurea induced apoptotic changes... -
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- siRNA Targeting Vascular Endothelial Growth Factor and Recombinant Human Prothrombin Kringle 2 Inhibits Leukemia-induced Angiogenesis
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Kim BJ, Kim SS
- KMID: 2083458
- Korean J Hematol.
- 2005 Dec;40(4):211-218.
- doi: 10.5045/kjh.2005.40.4.211
BACKGROUND: Vascular endothelial growth factor (VEGF) plays a role in the development of cancer and the progression of liquid tumors such as chronic lymphatic leukemia, non-Hodgkin lymphomas, and multiple myeloma.... -
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- Smad6 Gene and Suppression of Radiation-Induced Apoptosis by Genistein in K562 cells
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Jeong SJ, Jin YH, Yoo YJ, Do CH, Jeong MH, Huh GY, Bae HR, Yang KM, Moon CW, Oh SG, Hur WJ, Lee HS
- KMID: 2198676
- J Korean Soc Ther Radiol Oncol.
- 2001 Sep;19(3):245-251.
PURPOSE: The genes involved on the suppression of radiation-induced apoptosis by genistein in K562 leukemia cell line was investigated. MATERIALS AND METHODS: K562 cells in exponential growth phase were irradiated... -
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- Radiation-induced Apoptosis is Differentially Modulated by PTK Inhibitors K562 Cells
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Lee HS, Moon CW, Hur WJ, Jeong SJ, Jeong MH, Lee JH, Lim YJ, Park HJ
- KMID: 1769007
- J Korean Soc Ther Radiol Oncol.
- 2000 Mar;18(1):51-58.
PURPOSE: The effect of PTK inhibitors (herbimycin A and genistein) on the induction of radiation-induce d apoptosis in Ph-positive K562 leukemia cell line was investigated. MATERIALS AND METHODS: K562 cells in exponential... -
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- Effect of Verapamil on Cellular Uptake of Tc-99m MIBI and Tetrofosmin on Several Cancer Cells
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Kim DH, Yoo JA, Bae JH, Jeong SY, Suh MR, Ahn BC, Lee KB, Lee J
- KMID: 1590235
- Korean J Nucl Med.
- 2004 Feb;38(1):85-98.
PURPOSE: Cellular uptake of 99mTc-sestamibi (MIBI) and 99mTc-tetrofosmin (TF) is low in cancer cells expressing multidrug resistance (MDR) by p-glycoprotein (Pgp) or multidrug related protein (MRP). Verapamil is known to... -
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- Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-X(L) involved in cardiotoxin III-induced apoptosis in K562 cells
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Yang SH, Chien CM, Lu MC, Lin YH, Hu XW, Lin SR
- KMID: 1110128
- Exp Mol Med.
- 2006 Aug;38(4):435-444.
Cardiotoxin III (CTX III), a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. CTX III-induced K562 cell apoptosis... -
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- LncRNA MEG3 Regulates Imatinib Resistance in Chronic Myeloid Leukemia via Suppressing MicroRNA-21
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Zhou X, Yuan P, Liu Q, Liu Z
- KMID: 2389380
- Biomol Ther.
- 2017 Sep;25(5):490-496.
- doi: 10.4062/biomolther.2016.162
Imatinib resistance has become a major clinical problem for chronic myeloid leukemia. The aim of the present study was to investigate the involvement of MEG3, a lncRNA, in imatinib resistance... -
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- Assessment of the Cytotoxic and Apoptotic Effects of Chaetominine in a Human Leukemia Cell Line
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Yao J, Jiao R, Liu C, Zhang Y, Yu W, Lu Y, Tan R
- KMID: 2170526
- Biomol Ther.
- 2016 Mar;24(2):147-155.
- doi: 10.4062/biomolther.2015.093
Chaetominine is a quinazoline alkaloid originating from the endophytic fungus Aspergillus fumigatus CY018. In this study, we showed evidence that chaetominine has cytotoxic and apoptotic effects on human leukemia K562... -
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- Growth suppression of four cancer cells by hyperbaric nitrous oxide and methotrexate
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Jung CH, Sim JY, Ahn W
- KMID: 2031782
- Korean J Anesthesiol.
- 2010 Jan;58(1):61-69.
- doi: 10.4097/kjae.2010.58.1.61
BACKGROUND: Nitrous oxide concentration is easily controlled by respiratory ventilation. It suppresses bone marrow via the inhibition of thymidylate synthesis. The aim of this work was to determine the optimal... -
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- DNA-Protein Interaction of gamma-Globin Gene Promoter by Differentiation Inducers
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Kim DI, Park JI, Kim IH
- KMID: 2143367
- Korean J Hematol.
- 1999 Aug;34(3):436-444.
BACKGROUND: The K562 erythroleukemia cell line was used to study the molecular mechanisms regulating lineage commitment of hematopoietic cells. There are numerous similarities between the erythroid or megakaryocytic lineages. In... -
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- Signal Transduction Factors on the Modulation of Radiosusceptibility in K562 Cells
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Yang KM, Youn SM, Jeong SJ, Jang JY, Jo WS, Do CH, Yoo YJ, Shin YC, Lee HS, Hur WJ, Lim YJ, Jeong MH
- KMID: 2198630
- J Korean Soc Ther Radiol Oncol.
- 2003 Sep;21(3):227-237.
PURPOSE: The human chronic myelogenous leukemia cell line, K562, expresses the chimeric bcr-abl oncoprotein, whose deregulated protein tyrosine kinase activity antagonizes the induction of apoptosis via DNA damaging agents. Previous... -
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- Selenoprotein S Suppression Enhances the Late Stage Differentiation of Proerythrocytes Via SIRT1
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Yang HY, Chung KJ, Park HR, Han SJ, Lee SR, Chay KO, Kim IY, Park BJ, Lee TH
- KMID: 1457118
- Int J Oral Biol.
- 2010 Jun;35(2):61-67.
Selenoprotein S (SelS) is widely expressed in diverse tissues where it localizes in the plasma membrane and endoplasmic reticulum. We studied the potential function of SelS in erythrocyte differentiation using... -
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- Human Activated Lymphocyte Treated with Anti-CD3, CD16, CD56 Monoclonal Antibody and IL-2
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Hong SM, Lee DW, Kang JG, Kim HS, Cho SH
- KMID: 2150584
- Immune Netw.
- 2005 Mar;5(1):11-15.
- doi: 10.4110/in.2005.5.1.11
BACKGROUND: Throughtout the last three decades, the therapy of leukemias and lymphoma has set the stage for curative cancer therapy in systemic malignant disease. This was the result of an... -
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- Evaluation of cytolytic activity and phenotypic changes of circulating blood immune cells in patients with colorectal cancer by a simple preparation of peripheral blood mononuclear cells
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Kim JC, Choi J, Lee SJ, Lee YA, Jeon YM, Kang YW, Lee JK
- KMID: 2324877
- J Korean Surg Soc.
- 2013 Nov;85(5):230-235.
PURPOSE: This study aimed to assess the cytolytic activity and the phenotype of circulating blood immune cells in cancer patients by using a simple preparation of peripheral blood mononuclear cells... -
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