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What’s new in gynecologic pathology 2021: vulva, cervix, and uterus

Parra-Herran C, Bennett JA

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What’s New in Pathology Newsletter by PathologyOutlines.com

Pernick N

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Multiple hepatocyte nuclear factor 1A (HNF1A)-inactivated hepatocellular adenomas arising in a background of congenital hepatic fibrosis

Lee Y, Park H, Lee K, Lee Y, Lee K, Kim H

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Adenocarcinoma of the minor salivary gland with concurrent MAML2 and EWSR1 alterations

Choi S, Cho J, Lee SE, Baek CH, Kim YK, Kim HJ, Ko YH

Salivary gland tumors are histologically diverse, and each entity has distinctive histopathological and molecular features. We report two cases of salivary gland tumors with unique histological and molecular findings, which...
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Non-conventional dysplastic subtypes in inflammatory bowel disease: a review of their diagnostic characteristics and potential clinical implications

Choi WT

The early detection and grading of dysplasia is the current standard of care to minimize mortality from colorectal cancer (CRC) in patients with inflammatory bowel disease. With the development of...
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A study of pathological characteristics and BRAF V600E status in Langerhans cell histiocytosis of Vietnamese children

Phan TDA, Phung BG, Duong TT, Hoang VA, Ngo DQ, Trinh NDT, Tran TT

Background: Langerhans cell histiocytosis (LCH) is more common in children than adults and involves many organs. In children, the BRAF V600E mutation is associated with recurrent and high-risk LCH. Methods: We...
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Malignant rhabdoid tumor of the kidney in an adult with loss of INI1 expression and mutation in the SMARCB1 gene

Han E, Kim J, Jung MJ, Chin S, Lee SW, Moon A

A 57-year-old man with left flank pain was referred to our institute. Computed tomography scans revealed two enhancing masses in the left kidney. The clinical diagnosis was renal cell carcinoma...
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MicroRNA-552 expression in colorectal cancer and its clinicopathological significance

Im J, Nam SK, Lee HS

Background: MicroRNA-552 (miR-552) has been reported to correlate with the development and progression of various cancers, including colorectal cancer (CRC). This study aimed to investigate miR-552 expression in cancer tissue...
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A case of concomitant EGFR/ALK alteration against a mutated EGFR background in early-stage lung adenocarcinoma

Lee KC, Koh J, Chung DH, Jeon YK

Rare cases of lung adenocarcinoma (LUAD) with concomitant epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) translocation have been reported. However, their clonal and evolutional relationship remains...
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Histologically confirmed distant metastatic urothelial carcinoma from the urinary bladder: a retrospective review of one institution’s 20-year experience

Yoo Y, Lee J, Park HS, Cho MS, Sung SH, Park S, Choi E

Background: Urothelial carcinoma (UC) accounts for roughly 90% of bladder cancer, and has a high propensity for diverse differentiation. Recently, certain histologic variants of UC have been recognized to be...
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Deep learning for computer-assisted diagnosis of hereditary diffuse gastric cancer

Rasmussen SA, Arnason T, Huang WY

Background: Patients with hereditary diffuse gastric cancer often undergo prophylactic gastrectomy to minimize cancer risk. Because intramucosal poorly cohesive carcinomas in this setting are typically not grossly visible, many pathologists...
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The prognostic significance of p16 expression pattern in diffuse gliomas

Park JW, Kang J, Lim KY, Kim H, Kim SI, Won JK, Park CK, Park SH

Background: CDKN2A is a tumor suppressor gene that encodes the cell cycle inhibitor protein p16. Homozygous deletion of the CDKN2A gene has been associated with shortened survival in isocitrate dehydrogenase...
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