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Major clinical research advances in gynecologic cancer in 2016: 10-year special edition

Suh DH, Kim M, Kim K, Kim HJ, Lee KH, Kim JW

In 2016, 13 topics were selected as major research advances in gynecologic oncology. For ovarian cancer, study results supporting previous ones regarding surgical preventive strategies were reported. There were several...
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Surgical treatment of early ovarian cancer with compartmental resection of regional lymphatic network and indocyanine-green-guided targeted compartmental lymphadenectomy (TCL, paraaortic part)

Kimmig R, Buderath P, Mach P, Rusch P, Aktas B

OBJECTIVE: Whether pelvic and para-aortic lymphadenectomy is of therapeutic benefit in advanced ovarian cancer will remain unclear until the publication of the Arbeitsgemeinschaft Gynäkologische Onkologie lymphadenectomy in ovarian neoplasms (AGO...
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Prevention of lymphocele by using gelatin-thrombin matrix as a tissue sealant after pelvic lymphadenectomy in patients with gynecologic cancers: a prospective randomized controlled study

Kim YH, Shin HJ, Ju W, Kim SC

OBJECTIVE: This prospective randomized controlled pilot study aimed to find whether gelatin-thrombin matrix used as a tissue sealant (FloSeal) can prevent the occurrence of pelvic lymphocele in patients with gynecologic...
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Elevated plasma fibrinogen levels and prognosis of epithelial ovarian cancer: a cohort study and meta-analysis

Luo Y, Kim HS, Kim M, Lee M, Song YS

OBJECTIVE: To evaluate the effect of elevated plasma fibrinogen levels on the prognosis of epithelial ovarian cancer (EOC). METHODS: We reviewed the data of 217 patients with advanced-stage EOC between 2000...
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Increased risk of breast cancer in women with uterine myoma: a nationwide, population-based, case-control study

Tseng JJ, Chen YH, Chiang HY, Lin CH

OBJECTIVE: To evaluate if uterine myoma is associated with breast cancer. METHODS: This case-control study used a nationwide database in Taiwan. We identified 24,315 patients with newly diagnosed breast cancer as...
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Randomized study between radical surgery and radiotherapy for the treatment of stage IB–IIA cervical cancer: 20-year update

Landoni F, Colombo A, Milani R, Placa F, Zanagnolo , Mangioni C

OBJECTIVE: Stage IB–IIA cervical carcinoma can be equally cured either by radical surgery or radiotherapy (RT). Albeit such policies show the same efficacy, they carry a different morbidity. This is...
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Inhibition of autophagy protein LC3A as a therapeutic target in ovarian clear cell carcinomas

Miyamoto M, Takano M, Aoyama T, Soyama H, Yoshikawa , Tsuda H, Furuya K

OBJECTIVE: Ovarian clear cell carcinoma (CCC) is one of histological subtypes showing poor prognosis due to chemoresistance. The association of autophagy-related proteins and clinical implementation in CCC has not been...
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Prognostic significance of preoperative ¹⁸F-FDG PET/CT in uterine leiomyosarcoma

Park JY, Lee JW, Lee HJ, Lee JJ, Moon SH, Kang SY, Cheon GJ, Chung HH

OBJECTIVE: Uterine leiomyosarcoma (LMS) is a rare and aggressive disease with poor outcome. Due to its rarity and conflict of data, investigation on finding prognostic factor is challenging. The aim...
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An open-label, multicenter, phase I trial of a cremophor-free, polymeric micelle formulation of paclitaxel combined with carboplatin as a first-line treatment for advanced ovarian cancer: a Korean Gynecologic Oncology Group study (KGOG-3016)

Lee SW, Kim YM, Kim YT, Kang SB

OBJECTIVE: This phase I study aimed to determine the maximum tolerated dose (MTD) of Genexol-PM, when combined with carboplatin, as a first-line treatment in patients with advanced ovarian cancer. METHODS: This...
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Practice guidelines for management of cervical cancer in Korea: a Korean Society of Gynecologic Oncology Consensus Statement

Lim MC, Lee M, Shim SH, Nam EJ, Lee JY, Kim HJ, Lee YY, Lee KB, Park JY, Kim YH, Ki KD, Song YJ, Chung HH, Kim S, Lee JW, Kim JW, Bae DS, Lee JM

Clinical practice guidelines for gynecologic cancers have been developed by academic society from several countries. Each guideline reflected their own insurance system and unique medical environment, based on the published...
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