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Combined Multimodality Treatment including Surgery

Bang MJ, Bong JG, Park JH, Jeong MH, Paik SM

An ipsilateral supraclavicular lymph node recurrence of breast cancer after surgery has been considered a predecessor to distant metastases. There still is a debate as to whether breast carcinoma patients...
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Granulomatous mastitis

Park IK, Go DK, Choi IS, Choi WJ, Yoon DS, Lee JU, Kim YM, Kim KW

Granulomatous Mastitis (GM) is a rare chronic inflammatory lesion of the breast that clinically simulate carcinoma. The purpose of this report is to review the clinicopathological features of this clinical...
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The Clinicopathologic Characteristics of 38 Metaplastic Carcinomas of the Breast

Park JH, Han W, Kim SW, Lee JE, Shin HJ, Kim SW, Choe KJ, Oh SK, Youn YK, Noh DY

PURPOSE: Metaplastic carcinomas of the breast (MCBs) are rare diseases. The aim of this study is to evaluate the clinicopathologic characteristics of MCBs and to compare them with those of...
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Clinical Significance of DAX-1 Expression using Immunihistochemical Staining in Breast Cancer

Lee CY, Chang ED, Kim KH, Kim JI, Ahn CH, Park WC, Song BJ, Jung SS, Kim JS

PURPOSE: There have been some reports that DAX-1 (Dosage-sensitive sex reversal, Adrenal hypoplasia critical region, on chromosome X, gene 1) can modify the estrogen receptor-beta and the progesterone and androgen...
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Expression of estrogen receptor beta, estrogen receptor alpha and cyclooxygenase II in advanced breast cancer

Baek JM, Sung GY, Lee DS, Chun KH, Lee DH, Seo YJ, Choi SH, Park WC, Kim JS, Song BJ, Oh SJ, Kim W, Park IY, Jung SS, Lim KW, Won JM, Chun CS, Lee JH, Kim JA

PURPOSE: Although the role of the estrogen receptor alpha (ER alpha, previously called the estrogen receptor) in breast cancer is well established, that of the second human estrogen receptor (ER),...
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FAS (Fatty acid synthase) expression in breast cancer

Koo TY, Go DK, Choi IS, Choi WJ, Yoon DS, Sul HJ, Kim YM, Kim BK

PURPOSE: Fatty acid synthase (FAS) is a multi-enzyme molecule that plays a role in the de novo biosynthesis of fatty acids. FAS is expressed at low levels in most normal...
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Detection of micrometastasis in fixed paraffin-embedded Sentinel Lymph Nodes of Breast cancer using RT-PCR

Jeong J, Choi EC, Choi Y, Lee IK, Lee SA, Park JH, Ryu YH, Jung WH, Lee HD

PURPOSE: Sentinel lymph node (SLN) biopsy is considered a highly accurate and very economic method of assessing the axillary nodal status in breast cancer patients. Recently immunohistochemical (IHC) staining and...
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Survival Analyses in Breast Cancer According to Over-expression and Amplification of HER2

Kim SS, Park WC, Lee DH, Kim JS, Oh SJ, Song BJ, Jung SS, Myung JH, Lee JH

PURPOSE: HER2 is a 185-kDa transmembrane protein, which shares a considerable homology with the epidermal growth factor receptor. The over-expression of HER2 has been reported to be associated with a...
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Overexpression of the Bmi-1 Oncoprotein correlates with Axillary Lymph Node Metastases in Invasive Ductal Breast Cancer

Youn HJ, Jung SH

PURPOSE: The modulation of Bmi-1 is observed in several tumor tissues, with its heightened protein level suspected of being involved in tumorigenesis by acting as a transcriptional repressor in the...
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Characterization of the Differentially Expressed Genes in Human Breast Cancer using Subtractive Hybridization

Choi EJ, An HJ, Yu NM, Kim JK

PURPOSE: Although breast cancer the most common cancer for women remains a significant health problem, it has not been systematically studied until now. In an attempt to identify novel genes...
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Tamoxifen Resistance and Crosstalk of Signal Transduction in Breast Cancer

Park WC

In the hormonal therapy of breast cancer, tamoxifen is currently the standard treatment for estrogen receptor (ER)-positive patients. A response to tamoxifen has been reported in only 2/3 of patients...
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