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Mitochondrial Dysfunction as a Cause of Neurological Diseases

Kim CJ

No abstract available.
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How to Interpret the Effects Shown in Animal Study

Kim KH

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Dysfunctional Mitochondrial Bioenergetics and Synaptic Degeneration in Alzheimer Disease

Tang J, Oliveros A, Jang MH

Synapses are sites of high energy demand which are dependent on high levels of mitochondrial derived adenosine triphosphate. Mitochondria within synaptic structures are key for maintenance of functional neurotransmission and...
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Treadmill Exercise Ameliorates Chemotherapy-Induced Muscle Weakness and Central Fatigue by Enhancing Mitochondrial Function and Inhibiting Apoptosis

Park SS, Park HS, Jeong H, Kwak HB, No MH, Heo JW, Yoo SZ, Kim TW

PURPOSE: Chemotherapy is associated with the side effects including damage to the mitochondrial DNA. Doxorubicin (DOX) serves as a chemotherapeutic agent for the patients with breast cancer or prostate cancer....
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Effects of Acute Exercise on Mitochondrial Function, Dynamics, and Mitophagy in Rat Cardiac and Skeletal Muscles

Yoo SZ, No MH, Heo JW, Park DH, Kang JH, Kim JH, Seo DY, Han J, Jung SJ, Kwak HB

PURPOSE: This study aimed to investigate the effects of single-bout exercise on mitochondrial function, dynamics (fusion, fission), and mitophagy in cardiac and skeletal muscles. METHODS: Fischer 344 rats (4 months old)...
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Gadd45b Acts as Neuroprotective Effector in Global Ischemia-Induced Neuronal Death

Cho CH, Byun HR, Jover-Mengual T, Pontarelli F, Dejesus C, Cho AR, Zukin RS, Hwang JY

PURPOSE: Transient global ischemia arising in human due to cardiac arrest causes selective, delayed neuronal death in hippocampal CA1 and cognitive impairment. Growth arrest and DNA-damage-inducible protein 45 beta (Gadd45b)...
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Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway

Kim SE, Ko IG, Ji ES, Jin JJ, Hwang L, Kim SH, Cho S, Kim CJ, Kim K, Kim KH

PURPOSE: Circadian rhythm affects learning process, memory consolidation, and long-term memory. In this study, the alleviating effect of exercise on circadian rhythm disruption-induced memory deficits was investigated. METHODS: BMAL1 knockdown transgenic...
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