- Regulation of Osteoclast Differentiation by Cytokine Networks
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Amarasekara DS, Yun H, Kim S, Lee N, Kim H, Rho J
- KMID: 2404891
- Immune Netw.
- 2018 Feb;18(1):e8.
- doi: 10.4110/in.2018.18.e8
Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating factor and receptor activator of NF-κB ligand... -
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- Production of IL-15 and lts Functional Study in Mouse Splenocyte Activation
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Han IS, Park JW
- KMID: 1550738
- Korean J Immunol.
- 1999 Dec;21(4):297-302.
After the synthesis of IL-15 cDNA from the total RNA of mouse spleen, it was inserted into the prokaryotic expression vector, pRseta, and eukaryotic expression vector, pcDNA3.0, respectively. Subsequently, the... -
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- Elevated serum interleukin 15 (IL-15) in Behcet's disease
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Park KS, Min SY, Cho ML, Yoon CH, Kim YJ, Park JS, Choi JJ, Kim WU, Min DJ, Hong YS, Min JK, Park SH, Cho CS, Kim HY
- KMID: 1598559
- J Korean Rheum Assoc.
- 2002 Jun;9(2):117-123.
OBJECTIVE: To evaluate clinical significance of interleukin 15 (IL-15) in patients with Behcet's disease (BD). METHODS: Serum samples were obtained from 31 patients with BD and 29 healthy controls. BD patients... -
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- Enhancement of Human Monocyte Activities against Aspergillus fumigatus by Interleukin-15
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Cho JH, Chang KH, Kim HY, Song YG, Kim CO, Park YS, Hong SK, Huh A, Yeon JS, Kim JM
- KMID: 2307091
- Korean J Med Mycol.
- 2001 Jun;6(2):64-69.
BACKGROUND: Despite recent advances in antifungal chemotherapy, invasive aspergillosis remains an important cause of morbidity and mortality in immunocompromised patients. Interleukin-15 (IL-15) is a cytokine that is known to enhance... -
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- New Immunosuppressive Agent: The Effects of an Antagonist IL-15/IgG Fusion Protein
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Kim YS, Chae DW, Strom TB
- KMID: 2144934
- J Korean Soc Transplant.
- 1998 Nov;12(2):173-182.
Owing to shared receptor components, the biological activities of IL-15 are similar to those of IL-2. However the patterns of tissue expression of IL-2/IL-2R alpha and IL-15/IL-15R differ. The development... -
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- Elevated serum interleukin-15 levels in systemic lupus erythematosus
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Park YB, Kim DS, Lee WK, Suh CH, Lee SK
- KMID: 711660
- Yonsei Med J.
- 1999 Aug;40(4):343-348.
- doi: 10.3349/ymj.1999.40.4.343
Interleukin-15 (IL-15) has multiple biological properties, including the induction of other cytokine production and the inhibition of T cell apoptosis. Recently, IL-15 was reported to have a major... -
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- Cardiopulmonary Bypass-induced Gene Expressions of Proinflammatory Cytokines and Chemokines
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Yu JH, Jo EK, Park JK, Kang SK, Na MH, Lim SP, Lee Y
- KMID: 1915665
- Korean J Thorac Cardiovasc Surg.
- 2002 Feb;35(2):118-126.
BACKGROUND: Cardiopulmonary bypass(CPB) induces the productions of several inflammatory mediators that may be implicated in postoperative organ dysfunction, a problem to which the pediatric population is particularly prone. The purpose... -
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- Out-sourcing for Trans-presentation: Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
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Park JY, Ligons DL, Park JH
- KMID: 2404895
- Immune Netw.
- 2018 Feb;18(1):e13.
- doi: 10.4110/in.2018.18.e13
IL-15 is a cytokine of the common γ-chain family that is critical for natural killer (NK), invariant natural killer T (iNKT), and CD8 memory T cell development and homeostasis. The... -
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- IL-15 Induced an Increased SDF-1 Expression in the Synovial Fibroblasts of Patients with Rheumatoid Arthritis
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Park YE, Kim SI, Park SH, Baek SH, Oh HJ, Heo YM, Cho ML
- KMID: 2334911
- J Korean Rheum Assoc.
- 2010 Sep;17(3):238-245.
OBJECTIVE: Interleukin-15 (IL-15) recruits and activates synovial T cells, and IL-15 plays an important role in amplifying and perpetuating inflammation in the pathogenesis of rheumatoid arthritis (RA). Stromal cell-derived factor-1... -
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- Restoration of P-glycoprotein function is involved in the increase of natural killer activity with exogenous interleukin-15 in human immunodeficiency virus-infected individuals
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Chang KH, Kim JM, Yoo NC, Kim WH, Park JH, Choi IH, Kim HS, Lee KW, Song YG, Hong SK, Kim HY
- KMID: 1062239
- Yonsei Med J.
- 2000 Oct;41(5):600-606.
- doi: 10.3349/ymj.2000.41.5.600
A depressed level of natural killer (NK) activity is one of the various immunologic abnormalities in human immunodeficiency virus (HIV) infection. Interleukin-15 (IL-15), an immunotherapeutic candidate in HIV infection, increases... -
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- Spontaneous programmed cell death of peripheral blood mononuclear cells from HIV-infected persons is decreased with interleukin-15
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Chang KH, Kim JM, Kim HY, Song YG, Choi YH, Park YS, Cho JH, Hong SK
- KMID: 1060280
- Yonsei Med J.
- 2000 Feb;41(1):112-118.
- doi: 10.3349/ymj.2000.41.1.112
Interleukin 15 (IL-15) is an important regulatory cytokine in cellular immunity. In vitro replacement of IL-15 has been shown to enhance immunity in Human immunodeficiency virus type 1 (HIV-1) infected... -
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- Effect of Treadmill Exercise on Interleukin-15 Expression and Glucose Tolerance in Zucker Diabetic Fatty Rats
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Kim HJ, Park JY, Oh SL, Kim YA, So B, Seong JK, Song W
- KMID: 1965983
- Diabetes Metab J.
- 2013 Oct;37(5):358-364.
- doi: 10.4093/dmj.2013.37.5.358
BACKGROUND: Interleukin-15 (IL-15), a well-known myokine, is highly expressed in skeletal muscle and is involved in muscle-fat crosstalk. Recently, a role of skeletal muscle-derived IL-15 in the improvement of glucose... -
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- Role of IL-15 in Sepsis-Induced Skeletal Muscle Atrophy and Proteolysis
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Kim HC, Cho HY, Hah YS
- KMID: 1842924
- Tuberc Respir Dis.
- 2012 Dec;73(6):312-319.
- doi: 10.4046/trd.2012.73.6.312
BACKGROUND: Muscle wasting in sepsis is associated with increased proteolysis. Interleukin-15 (IL-15) has been characterized as an anabolic factor for skeletal muscles. Our study aims to investigate the role of... -
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- Regulation of Interleukin-17 Production in Patients with Rheumatoid Arthritis by Phosphoinositide 3-kinase (PI3K)/ Akt and Nuclear Factor KappaB (NF-kappaB) Dependent Signal Transduction Pathway
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Kim KW, Cho ML, Lee SH, Min SY, Park MK, Park SH, Jue DM, Kim HY
- KMID: 2054236
- Immune Netw.
- 2003 Dec;3(4):310-319.
- doi: 10.4110/in.2003.3.4.310
Inflammatory mediators has been recognized as an important role in the pathogenesis of rheumatoid arthritis (RA). IL-17 is increasingly recognized as an important regulator of immune and inflammatory responses, including... -
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- Reciprocal Activation of Fibroblast-like Synoviocyte and Type II Collagen-reactive T cell in Rheumatoid Arthritis
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Yoon CH, Park MK, Cho ML, Ko HJ, Park KS, Kim WU, Min JK, Lee SH, Hong YS, Park SH, Cho CS, Kim HY
- KMID: 2202351
- J Korean Rheum Assoc.
- 2004 Mar;11(1):25-36.
OBJECTIVE: To investigate the interaction between type II collagen (CII)-reactive T cell and fibroblast-like synoviocyte in rheumatoid arthritis (RA). METHODS: Peripheral blood T cells from RA patients were cultured with... -
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- T Cell Receptor Rearrangement in NKT Cells Differentiated from Cord Blood CD34+ Cells
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Jung YJ, Woo SY
- KMID: 2352866
- Ewha Med J.
- 2003 Jun;26(2):137-142.
- doi: 10.12771/emj.2003.26.2.137
OBJECTIVES: To investigate the time of rearrangement of the TCR gene in the process of NKT cell differentiation from CD34+ human cord blood cells in vitro. METHODS: We isolated the CD34+... -
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- Correlations between the Intrarenal Expression of Various Cytokines and Chemokines and the Clinicopathologic Characteristics in IgA Nephropathy
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Lim CS, Zheng S, Kim YS, Ahn C, Han JS, Kim S, Lee JS, Lee HS, Chae DW
- KMID: 2079175
- Korean J Nephrol.
- 2001 Jul;20(4):545-555.
IgA nephropathy is one of the most common forms of primary glomerulonephritis in adults, and the pathogenetic mechanisms seem to be diverse. Proinflammatory cytokines, Th1/Th2 cytokines, and chemokines would be... -
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- Ex vivo Expansion of Human Natural Killer Cells from Blood Retained in a Disposable Platelet Apheresis Set
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Shin DJ, Cho D, Jang YY, Park JY, Kim JS, Kim SK, Lee JJ, Jang MJ, Shin MG, Ryang DW
- KMID: 1440719
- Korean J Blood Transfus.
- 2012 Apr;23(1):28-37.
BACKGROUND: Natural killer cells expanded from human peripheral blood (PB) have been used in cancer immunotherapy research. Although most research teams have access to human PB, it is necessary to... -
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- Elevated Serum Levels of Vascular Endothelial Growth Factor in Behcet's Syndrome
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Hong JH, Kim HS, Kim HR, Park MK, Yoon CH, Lee SH, Kim HY, Park SH
- KMID: 2334812
- J Korean Rheum Assoc.
- 2005 Sep;12(3):189-196.
OBJECTIVE: Vascular endothelial growth factor (VEGF) is a potent endothelium-specific cytokine and stimulates inflammation and angiogenesis. Vascular endothelial dysfunction is one of the characteristic features of Behcet's syndrome. We previously... -
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- Engineering of Anti-CD133 Trispecific Molecule Capable of Inducing NK Expansion and Driving Antibody-Dependent Cell-Mediated Cytotoxicity
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Schmohl JU, Felices M, Oh F, Lenvik AJ, Lebeau AM, Panyam J, Miller JS, Vallera DA
- KMID: 2394832
- Cancer Res Treat.
- 2017 Oct;49(4):1140-1152.
- doi: 10.4143/crt.2016.491
PURPOSE: The selective elimination of cancer stem cells (CSCs) in tumor patients is a crucial goal because CSCs cause drug refractory relapse. To improve the current conventional bispecific immune-engager platform,... -
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