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The Effect of 17beta- Estradiol on the Messenser Ribonucleic Acid ( mRNA ) Expression of Insulin-like Growth Factor Binding Proteins in Normal Myometrium and Uterine Leiomyoma

Kim SS, Kim JK, Lee JY

  • KMID: 1855595
  • Korean J Obstet Gynecol.
  • 1998 Jan;41(1):17-27.
Uterine leiomyoma is the most common female reproductive tract tumor during reproductive years. Estrogen has been implicated the most important factor in leimyoma growth. Recently studies have also implicated insulin-like...
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The Effect of Sex Steroid Hormone on the Expression of Insulin-Like Growth Factor Binding Preteins mRNA in the Explant Cultured from Human Uterine Myoma and Adjacent Normal Myometrium

Lee JY, Kim JK, Seo CS, Kim SH, Choi YM, Moon SY

  • KMID: 1853224
  • J Korean Soc Endocrinol.
  • 1998 Mar;13(1):34-44.
BACKGROUND: Sex steroid hormones are believed to play an important role in the genesis and growth of uterine myoma. Several studies suggest a possible role of insulin-like growth factor(IGF) as...
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Expression of Human Insulin-Like Growth Factor Binding Protein ( IGFBP )-4 , 5 , 6 mRNA and Immunohistochemical Localization of IGFBP-4 in Human Fallopian Tube

Choi DS, Lee JY

  • KMID: 2260965
  • Korean J Obstet Gynecol.
  • 1998 May;41(5):1369-1383.
The fallopian tube is a dynamic structure where the epithelium undergoes sex steroid hormone-dependent specific changes and in which gamete transport, maturation, fertilization, and early embryo development and transport occur....
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Insulin Like Growth Factor Binding Protein-5 Regulates Excessive Vascular Smooth Muscle Cell Proliferation in Spontaneously Hypertensive Rats via ERK 1/2 Phosphorylation

Lee DH, Kim JE, Kang YJ

Insulin-like growth factor binding proteins (IGFBPs) are important components of insulin growth factor (IGF) signaling pathways. One of the binding proteins, IGFBP-5, enhances the actions of IGF-1, which include the...
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Alterations of Insulin-like Growth Factor-I mRNA and IGF Binding Protein-5 mRNA Expression Following Hypoxic-Ischemic Brain Injury in Immature Rat

Lee KH, Lim JH, Choi BM, Eun BL

  • KMID: 2193580
  • J Korean Soc Pediatr Endocrinol.
  • 2003 Jun;8(1):56-63.
PURPOSE:Insulin-like growth factor-I(IGF-I) is an essential anabolic factor for postnatal rat brain development and IGF-I expression is highly abundant during the first 21 days, critical growth period. Hypoxic-ischemic brain insults...
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Gene Expression Profiles of Uterine Normal Myometrium and Leiomyoma and Their Estrogen Responsiveness In Vitro

Lee EJ, Bajracharya P, Lee DM, Cho KH, Kim KJ, Bae YK, Kim MJ, Lee KH, Kim HJ, Song GH, Chun SS, Choi I

  • KMID: 1837531
  • Korean J Pathol.
  • 2010 Jun;44(3):272-283.
BACKGROUND: Uterine leiomyomas are common benign smooth muscle tumors among the reproductive aged-women. The research has been aimed to identify the differentially expressed genes between normal myometrium and leiomyoma and...
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Pitavastatin Regulates Ang II Induced Proliferation and Migration via IGFBP-5 in VSMC

Ha YM, Nam JO, Kang YJ

Angiotensin II (Ang II), a key mediator of hypertensive, causes structural changes in the arteries (vascular remodeling), which involve alterations in cell growth, vascular smooth muscle cell (VSMC) hypertrophy. Ang...
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MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis

Hong BK, You S, Yoo SA, Park D, Hwang D, Cho CS, Kim WU

Fibroblast-like synoviocytes (FLSs) constitute a major cell subset of rheumatoid arthritis (RA) synovia. Dysregulation of microRNAs (miRNAs) has been implicated in activation and proliferation of RA-FLSs. However, the functional association...
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