- Heat-Killed Saccharomyces cerevisiae, A Dectin-1 Agonist, Selectively Induces IgG4 Production by Human B Cells
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Park HY, Yoon HK, Kim JY, Park SR
- KMID: 2429838
- Immune Netw.
- 2018 Dec;18(6):e46.
- doi: 10.4110/in.2018.18.e46
Dectin-1 is a major receptor that recognizes fungal cell wall β-glucan. We previously reported that heat-killed Saccharomyces cerevisiae (HKSC), a Dectin-1 agonist, selectively induces IgG1 class switching in mouse B... -
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- Immunoglobulin Isotype Switching in a Plasma Cell Myeloma Patient Treated with High-dose Chemotherapy and Hematopoietic Stem Cell Transplantation
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Ham JY, Lee KM, Song KE
- KMID: 2312183
- Lab Med Online.
- 2011 Jul;1(3):158-162.
A malignant plasma cell clone usually produces a single abnormal monoclonal protein with a constant isotype. However, switching of paraprotein isotype has been reported to be a transient phenomenon associated... -
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- Newly Identified TLR9 Stimulant, M6-395 Is a Potent Polyclonal Activator for Murine B Cells
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Park MH, Jung YJ, Kim PH
- KMID: 2014653
- Immune Netw.
- 2012 Feb;12(1):27-32.
- doi: 10.4110/in.2012.12.1.27
BACKGROUND: Toll-like receptors (TLRs) have been extensively studied in recent years. However, functions of these molecules in murine B cell biology are largely unknown. A TLR4 stimulant, LPS is well... -
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- Vitamin C acts indirectly to modulate isotype switching in mouse B cells
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Woo A, Kim JH, Jeong YJ, Maeng HG, Lee YT, Kang JS, Lee WJ, Hwang YI
- KMID: 2168894
- Anat Cell Biol.
- 2010 Mar;43(1):25-35.
- doi: 10.5115/acb.2010.43.1.25
Vitamin C, one of essential micronutrients, has been reported to modulate the humoral immune responses in some mammals. We investigated whether vitamin C might modulate this response in mice by... -
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- Tiul1 and TGIF are Involved in Downregulation of TGFbeta1-induced IgA Isotype Expression
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Park KH, Nam EH, Seo GY, Seo SR, Kim PH
- KMID: 2150653
- Immune Netw.
- 2009 Dec;9(6):248-254.
- doi: 10.4110/in.2009.9.6.248
TGF-beta1 is well known to induce Ig germ-line alpha (GLalpha) transcription and subsequent IgA isotype class switching recombination (CSR). Homeodomain protein TG-interacting factor (TGIF) and E3-ubiquitin ligases TGIF interacting ubiquitin... -
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- Lactoferrin Combined with Retinoic Acid Stimulates B1 Cells to Express IgA Isotype and Gut-homing Molecules
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Kang SH, Jin BR, Kim HJ, Seo GY, Jang YS, Kim SJ, An SJ, Park SR, Kim WS, Kim PH
- KMID: 2150828
- Immune Netw.
- 2015 Feb;15(1):37-43.
- doi: 10.4110/in.2015.15.1.37
It is well established that TGF-beta1 and retinoic acid (RA) cause IgA isotype switching in mice. We recently found that lactoferrin (LF) also has an activity of IgA isotype switching... -
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- Murine γδ T Cells Render B Cells Refractory to Commitment of IgA Isotype Switching
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Han HJ, Jang YS, Seo GY, Park SG, Kang SG, Yoon SI, Ko HJ, Lee GS, Kim PH
- KMID: 2419770
- Immune Netw.
- 2018 Aug;18(4):e25.
- doi: 10.4110/in.2018.18.e25
γδ T cells are abundant in the gut mucosa and play an important role in adaptive immunity as well as innate immunity. Although γδ T cells are supposed to be... -
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- SUMO Proteins are not Involved in TGF-beta1-induced, Smad3/4-mediated Germline alpha Transcription, but PIASy Suppresses it in CH12F3-2A B Cells
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Lee SH, Kim PH, Oh SM, Park JH, Yoo YC, Lee J, Park SR
- KMID: 2150822
- Immune Netw.
- 2014 Dec;14(6):321-327.
- doi: 10.4110/in.2014.14.6.321
TGF-beta induces IgA class switching by B cells. We previously reported that Smad3 and Smad4, pivotal TGF-beta signal-transducing transcription factors, mediate germline (GL) alpha transcription induced by TGF-beta1, resulting in... -
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- Toll-like Receptor 1/2 Agonist Pam3CSK4 Suppresses Lipopolysaccharide-driven IgG1 Production while Enhancing IgG2a Production by B Cells
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Lee SH, Park SR
- KMID: 2404892
- Immune Netw.
- 2018 Feb;18(1):e10.
- doi: 10.4110/in.2018.18.e10
Interaction between pathogen-associated molecular patterns and pattern recognition receptors triggers innate and adaptive immune responses. Several studies have reported that toll-like receptors (TLRs) are involved in B cell proliferation, differentiation,... -
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- Characterization of Mouse B Lymphoma Cells (CH12F3-2A) for the Study of IgA Isotype Switching
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Jang YS, Choi SH, Park SR, Kim HA, Park JB, Kim PH
- KMID: 1515488
- Immune Netw.
- 2004 Dec;4(4):216-223.
- doi: 10.4110/in.2004.4.4.216
BACKGROUND: It is well known that IgA isotype switching is induced by TGF-beta1. LPS-activated mouse normal B cells well differentiate into IgA secreting plasma cells under the influence of TGF-beta1.... -
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- Alum Directly Modulates Murine B Lymphocytes to Produce IgG1 Isotype
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Jin BR, Kim SJ, Lee JM, Kang SH, Han HJ, Jang YS, Seo GY, Kim PH
- KMID: 2150765
- Immune Netw.
- 2013 Feb;13(1):10-15.
- doi: 10.4110/in.2013.13.1.10
Aluminum hydroxide (alum) is the most widely used adjuvant in human vaccines. Nevertheless, it is virtually unknown whether alum acts on B cells. In the present study, we explored the... -
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- The Niche of Follicular Helper T Cells in Systemic Autoimmune Diseases
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Jang E, Youn J
- KMID: 2168214
- Hanyang Med Rev.
- 2013 Feb;33(1):1-9.
- doi: 10.7599/hmr.2013.33.1.1
Production of thymus-dependent antibodies by autoreactive B cells requires help from T cells. Follicular helper T (Tfh) cells are a unique lineage of CD4+ T subsets present in the follicles... -
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- A Study of Susceptibility between Allergic Rhinitis and IL-13 Exon 4 G2044A Gene Polymorphism Study in Korean
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Lee JH, Choi TW, Lee JH, Choi SH, Kim MS, Min JY, Kim JJ
- KMID: 2276339
- Korean J Otolaryngol-Head Neck Surg.
- 2005 Jan;48(1):61-64.
BACKGROUND AND OBJECTIVES: High total serum IgE level is one of the characteristics seen in allergic rhinitis. IL-13 provides impetus to immunoglobulin class switching to IgE. The IL-13 promoter single... -
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- T Cell Dependent Antigen-Induced Immunoglobulin Isotype Swiching and Diifferentiation of Lymph Node
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Kim JG, Lee WJ
- KMID: 1550791
- Korean J Immunol.
- 1999 Mar;21(1):9-16.
Lymph nodes, one of peripheral lymphoid organs, are the sites, where the lymphocytes receive their initial instructions for producing effector functioning resulting in humoral or cell-mediated immunity. Each lymph node... -
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- Germinal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells
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Park HJ, Kim DH, Choi JM
- KMID: 2168215
- Hanyang Med Rev.
- 2013 Feb;33(1):10-16.
- doi: 10.7599/hmr.2013.33.1.10
Follicular helper T cells (Tfh) play a significant role in providing T cell help to B cells during the germinal center reaction, where somatic hypermutation, affinity maturation, isotype class switching,... -
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- Induction of Fas Antigen Expression, and Apotopsis of Human B Cell by CD40 and Tumor Necrosis Factor Receptor Ligation
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Chang DK, Yoo DH, Kim SY
- KMID: 1587011
- J Korean Rheum Assoc.
- 2001 Mar;8(1):20-33.
OBJECTIVE: CD40 and the TNFR belong to the NGF/TNFR supergene family. Ligation of CD40 on B cells induces activation ignals leading to proliferation, Ig isotype class switching, germinal center formation... -
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