- Increased B Cell Understanding Puts Improved Vaccine Platforms Just Over the Horizon
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Notario GR, Kwak K
- KMID: 2538489
- Immune Netw.
- 2022 Dec;22(6):e47.
- doi: 10.4110/in.2022.22.e47
In the face of an endlessly expanding repertoire of Ags, vaccines are constantly being tested, each more effective than the last. As viruses and other pathogens evolve to become more... -
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- Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier
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Akuzum B, Lee JY
- KMID: 2538488
- Immune Netw.
- 2022 Dec;22(6):e46.
- doi: 10.4110/in.2022.22.e46
T-helper-17 (Th17) cells and related IL-17-producing (type17) lymphocytes are abundant at the epithelial barrier. In response to bacterial and fungal infection, the signature cytokines IL-17A/F and IL-22 mediate the antimicrobial... -
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- Microbial Modulation in Inflammatory Bowel Diseases
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Yu J, Cheon JH
- KMID: 2538484
- Immune Netw.
- 2022 Dec;22(6):e44.
- doi: 10.4110/in.2022.22.e44
Gut dysbiosis is one of prominent features in inflammatory bowel diseases (IBDs) which are of an unknown etiology. Although the cause-and-effect relationship between IBD and gut dysbiosis remains to be... -
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- Immunologic Basis of Type 2 Biologics for Severe Asthma
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Sim S, Choi Y, Park HS
- KMID: 2538487
- Immune Netw.
- 2022 Dec;22(6):e45.
- doi: 10.4110/in.2022.22.e45
Asthma is a chronic airway inflammatory disease characterized by reversible airway obstruction and airway hyperreactivity to various environmental stimuli, leading to recurrent cough, dyspnea, and wheezing episodes. Regarding inflammatory mechanisms,... -
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- Low-Level Expression of CD138 Marks Naturally Arising Anergic B Cells
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Lee S, Yang JI, Lee JH, Lee HW, Kim TJ
- KMID: 2538492
- Immune Netw.
- 2022 Dec;22(6):e50.
- doi: 10.4110/in.2022.22.e50
Autoreactive B cells are not entirely deleted, but some remain as immunocompetent or anergic B cells. Although the persistence of autoreactive B cells as anergic cells has been shown in... -
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- Trypanosoma cruzi Dysregulates piRNAs Computationally Predicted to Target IL-6 Signaling Molecules During Early Infection of Primary Human Cardiac Fibroblasts
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Cooley A, Rayford KJ, Arun A, Villalta F, Lima MF, Pratap S, Nde PN
- KMID: 2538493
- Immune Netw.
- 2022 Dec;22(6):e51.
- doi: 10.4110/in.2022.22.e51
Trypanosoma cruzi, the etiological agent of Chagas disease, is an intracellular protozoan parasite, which is now present in most industrialized countries. About 40% of T. cruzi infected individuals will develop... -
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- Cynomolgus Macaque Model for COVID-19 Delta Variant
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Baek SH, Oh H, Koo BS, Kim G, Hwang EH, Jung H, An YJ, Park JH, Hong JJ
- KMID: 2538490
- Immune Netw.
- 2022 Dec;22(6):e48.
- doi: 10.4110/in.2022.22.e48
With the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, which are randomly mutated, the dominant strains in regions are changing globally. The development of preclinical animal models... -
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- MiR-182-5p Mediated by Exosomes Derived From Bone Marrow Mesenchymal Stem Cell Attenuates Inflammatory Responses by Targeting TLR4 in a Mouse Model of Myocardial Infraction
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Sun C, Li W, Li Y, Chen J, An H, Zeng G, Wang T, Guo Y, Wang C
- KMID: 2538491
- Immune Netw.
- 2022 Dec;22(6):e49.
- doi: 10.4110/in.2022.22.e49
Exosomes derived from mesenchymal stem cells (MSCs) could protect against myocardial infarction (MI). TLR4 is reported to play an important role in MI, while microRNA-182-5p (miR-182-5p) negatively regulates TLR4 expression.... -
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