Immune Netw.
2022 Dec;22(6):e46. 10.4110/in.2022.22.e46.
Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier
- Affiliations
-
- 1Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul 03722, Korea
- 2Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, Korea
- 3Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea
- KMID: 2538488
- DOI: http://doi.org/10.4110/in.2022.22.e46
Abstract
- T-helper-17 (Th17) cells and related IL-17-producing (type17) lymphocytes are abundant at the epithelial barrier. In response to bacterial and fungal infection, the signature cytokines IL-17A/F and IL-22 mediate the antimicrobial immune response and contribute to wound healing of injured tissues. Despite their protective function, type17 lymphocytes are also responsible for various chronic inflammatory disorders, including inflammatory bowel disease (IBD) and colitis associated cancer (CAC). A deeper understanding of type17 regulatory mechanisms could ultimately lead to the discovery of therapeutic strategies for the treatment of chronic inflammatory disorders and the prevention of cancer. In this review, we discuss the current understanding of the development and function of type17 immune cells at the intestinal barrier, focusing on the impact of microbiota-immune interactions on intestinal barrier homeostasis and disease etiology.
