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Affinity Maturation of an Epidermal Growth Factor Receptor Targeting Human Monoclonal Antibody ER414 by CDR Mutation

Chang KH, Kim MS, Hong GW, Seo MS, Shin YN, Kim SH

  • KMID: 2424210
  • Immune Netw.
  • 2012 Aug;12(4):155-164.
It is well established that blocking the interaction of EGFR with growth factors leads to the arrest of tumor growth, resulting in tumor cell death. ER414 is a human monoclonal...
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Calcium/Calmodulin-Dependent Protein Kinase is Involved in the Release of High Mobility Group Box 1 Via the Interferon-beta Signaling Pathway

Ma L, Kim SJ, Oh KI

  • KMID: 2424209
  • Immune Netw.
  • 2012 Aug;12(4):148-154.
Previously, we have reported that high mobility group box 1 (HMGB1), a proinflammatory mediator in sepsis, is released via the IFN-beta-mediated JAK/STAT pathway. However, detailed mechanisms are still unclear. In...
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The Past, Present, and Future of Adoptive T Cell Therapy

Choi D, Kim TG, Sung YC

  • KMID: 2424208
  • Immune Netw.
  • 2012 Aug;12(4):139-147.
Although adoptive T cell therapy (ACT) has become a promising immunotherapeutic regime for cancer treatment, its effectiveness has been hindered by several inherent shortcomings regarding safety and efficacy. During the...
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Immune Disorders and Its Correlation with Gut Microbiome

Hwang JS, Im CR, Im SH

  • KMID: 2424207
  • Immune Netw.
  • 2012 Aug;12(4):129-138.
Allergic disorders such as atopic dermatitis and asthma are common hyper-immune disorders in industrialized countries. Along with genetic association, environmental factors and gut microbiota have been suggested as major triggering...
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