- The significance of PR segment slope in the evaluation of exercise-induced ST depression as an indicator of myocardial ischemia
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Park CG, Kim YH, Seo HS, Im DS, Kim HK, Jin DG, Shim WJ, Oh DJ, Park JE, Ro YM
- KMID: 1698323
- Korean J Med.
- 1993 Oct;45(4):437-445.
No abstract available. -
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- A case of gastric granulocytic sarcoma in a patient with transformed acute leukemia from myelodysplastic syndrome
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Kim YS, Choi YW, Im DS, Lee TH, Im EH, Huh KC, Kang YW
- KMID: 2305855
- Korean J Med.
- 2008 May;74(5):570-573.
Granulocytic sarcoma is a localized tumor that's composed of immature cells of the granulocytic series. The tumor may be involved anywhere in the body, but we present here a rare... -
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- Development of Free Fatty Acid Receptor 4 (FFA4/GPR120) Agonists in Health Science
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Son SE, Kim NJ, Im DS
- KMID: 2510121
- Biomol Ther.
- 2021 Jan;29(1):22-30.
- doi: 10.4062/biomolther.2020.213
Till the 21st century, fatty acids were considered as merely building blocks for triglycerides, phospholipids, or cholesteryl esters. However, the discovery of G protein-coupled receptors (GPCRs) for free fatty acids at... -
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- Intercellular Lipid Mediators and GPCR Drug Discovery
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Im DS
- KMID: 2170658
- Biomol Ther.
- 2013 Nov;21(6):411-422.
G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets.... -
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- Suppressive Effect of Carnosol on Ovalbumin-Induced Allergic Asthma
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Lee JE, Im DS
- KMID: 2510125
- Biomol Ther.
- 2021 Jan;29(1):58-63.
- doi: 10.4062/biomolther.2020.050
Asthma is a chronic obstructive lung disease characterized by recurrent episodes of bronchoconstriction and wheezing. Conventional asthma treatment involves the suppression of airway inflammation or improving airway flow. Rosmarinus officialis,... -
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- Lodoxamide Attenuates Hepatic Fibrosis in Mice: Involvement of GPR35
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Kim MJ, Park SJ, Nam SY, Im DS
- KMID: 2507803
- Biomol Ther.
- 2020 Jan;28(1):92-97.
- doi: 10.4062/biomolther.2018.227
A previous pharmacogenomic analysis identified cromolyn, an anti-allergic drug, as an effective anti-fibrotic agent that acts on hepatocytes and stellate cells. Furthermore, cromolyn was shown to be a G protein-coupled... -
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- Pro-Inflammatory Role of S1P₃ in Macrophages
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Heo JY, Im DS
- KMID: 2455092
- Biomol Ther.
- 2019 Jul;27(4):373-380.
- doi: 10.4062/biomolther.2018.215
Sphingosine kinase 1 and its product, sphingosine 1-phosphate (S1P), as well as their receptors, have been implicated in inflammatory responses. The functions of receptors S1Pâ‚ and S1Pâ‚‚ on cell motility... -
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- 4-CMTB Ameliorates Ovalbumin-Induced Allergic Asthma through FFA2 Activation in Mice
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Lee JH, Im DS
- KMID: 2517161
- Biomol Ther.
- 2021 Jul;29(4):427-433.
- doi: 10.4062/biomolther.2020.176
Free fatty acid receptor 2 (FFA2, also known as GPR43), a G-protein-coupled receptor, has been known to recognize short-chain fatty acids and regulate inflammatory responses. FFA2 gene deficiency exacerbated disease... -
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- Analysis of a Sphingosine 1-phosphate Receptor hS1P3 in Rat Hepatoma Cells
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Im DS
- KMID: 2285242
- Korean J Physiol Pharmacol.
- 2002 Jun;6(3):139-142.
To examine intracellular signaling of human S1P3 (hS1P3), a sphingosine 1-phosphate (S1P) receptor in plasma membrane, hS1P3 DNA was transfected into RH7777 rat hepatoma cell line, and the inhibition of... -
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- Three Cases of Lesch-Nyhan Syndrome: Cases report
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Shin YB, Han JE, Kim KM, Yang SH, Im DS
- KMID: 2178522
- J Korean Acad Rehabil Med.
- 2005 Dec;29(6):673-677.
Lesch-Nyhan syndrome is a rare X-linked recessive metabolic disorder characterized by developmental delay, hyperuricemia, choreoathetosis, spasticity, mental retardation, and compulsive self-injurious behavior. This disorder results from a complete deficiency of... -
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- Calcium Signaling of Lysophosphatidylethanolamine through LPA1 in Human SH-SY5Y Neuroblastoma Cells
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Lee JM, Park SJ, Im DS
- KMID: 2375040
- Biomol Ther.
- 2017 Mar;25(2):194-201.
- doi: 10.4062/biomolther.2016.046
Lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, has been reported to be an intercellular signaling molecule. LPE mobilizes intracellular Ca²⺠through G-protein-coupled receptor (GPCR) in some cells types. However, GPCRs... -
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- Topical Application of S1P2 Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice
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Kang J, Lee JH, Im DS
- KMID: 2508208
- Biomol Ther.
- 2020 Nov;28(6):537-541.
- doi: 10.4062/biomolther.2020.036
Sphingosine-1-phosphate (S1P) and its receptors have been implicated in atopic dermatitis. S1P2 was found to function as a proallergic receptor, while its antagonist JTE-013 was found to suppress allergic asthma... -
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- p38 MAPK Inhibitor NJK14047 Suppresses CDNB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice
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Lee JH, Son SH, Kim NJ, Im DS
- KMID: 2534699
- Biomol Ther.
- 2022 Nov;30(6):501-509.
- doi: 10.4062/biomolther.2022.024
Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Suppression of MAPKs and NF-κB is implicated as a vital mechanism of action of several traditional Chinese medicines for AD therapy.... -
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- NJK14047 Suppression of the p38 MAPK Ameliorates OVA-Induced Allergic Asthma during Sensitization and Challenge Periods
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Lee JH, Son SH, Kim NJ, Im DS
- KMID: 2539587
- Biomol Ther.
- 2023 Mar;31(2):183-192.
- doi: 10.4062/biomolther.2022.078
p38 MAPK has been implicated in the pathogenesis of asthma as well as pro-allergic Th2 cytokines, orosomucoid-like protein isoform 3 (ORMDL3), regulation of sphingolipid biosynthesis, and regulatory T cell-derived IL-35.... -
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- FFA2 Activation Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice
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Kang J, Im DS
- KMID: 2500503
- Biomol Ther.
- 2020 May;28(3):267-271.
- doi: 10.4062/biomolther.2019.160
Gut microbiota produce dietary metabolites such as short-chain fatty acids, which exhibit anti-inflammatory effects. Free fatty acid receptor 2 (FFA2, formerly known as GPR43) is a specific receptor for short-chain... -
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- Suppressive Effect of CYM50358 S1P4 Antagonist on Mast Cell Degranulation and Allergic Asthma in Mice
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Jeon WJ, Chung KW, Lee JH, Im DS
- KMID: 2519614
- Biomol Ther.
- 2021 Sep;29(5):492-497.
- doi: 10.4062/biomolther.2020.206
Levels of sphingosine 1-phosphate (S1P), an intercellular signaling molecule, reportedly increase in the bronchoalveolar lavage fluids of patients with asthma. Although the type 4 S1P receptor, S1P4 has been detected... -
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- Deficiency of Sphingosine-1-Phosphate Receptor 2 (S1Pâ‚‚) Attenuates Bleomycin-Induced Pulmonary Fibrosis
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Park SJ, Im DS
- KMID: 2447859
- Biomol Ther.
- 2019 May;27(3):318-326.
- doi: 10.4062/biomolther.2018.131
Sphingosine 1-phosphate (S1P) levels are often found to be elevated in serum, bronchoalveolar lavage, and lung tissue of idiopathic pulmonary fibrosis patients and experimental mouse models. Although the roles of... -
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- Action and Signaling of Lysophosphatidylethanolamine in MDA-MB-231 Breast Cancer Cells
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Park SJ, Lee KP, Im DS
- KMID: 2170652
- Biomol Ther.
- 2014 Mar;22(2):129-135.
Previously, we reported that lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, can increase intracellular Ca2+ ([Ca2+]i) via type 1 lysophosphatidic acid (LPA) receptor (LPA1) and CD97, an adhesion G-protein-coupled receptor... -
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- Suppressive Effect of 4-Hydroxy-2-(4-Hydroxyphenethyl) Isoindoline-1,3-Dione on Ovalbumin-Induced Allergic Asthma
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Huang J, Su M, Lee BK, Kim MJ, Jung JH, Im DS
- KMID: 2427506
- Biomol Ther.
- 2018 Nov;26(6):539-545.
- doi: 10.4062/biomolther.2018.006
4-Hydroxy-2-(4-hydroxyphenethyl)isoindoline-1,3-dione (PD1) is a synthetic phthalimide derivative of a marine compound. PD1 has peroxisome proliferator-activated receptor (PPAR) γ agonistic and anti-inflammatory effects. This study aimed to investigate the effect of... -
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- Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery
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Park SJ, Im DS
- KMID: 2367621
- Biomol Ther.
- 2017 Jan;25(1):80-90.
- doi: 10.4062/biomolther.2016.160
Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G... -
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