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Decreased Expression of 15-hydroxyprostaglandin Dehydrogenase in Gastric Carcinomas

Jang TJ, Ji YS, Jung KH

PURPOSE: Gastric carcinoma tissues release high level of prostaglandin E2 (PGE2) when compared to non-neoplastic mucosa, and cyclooxygenase-2 (COX-2), which is the rate-limiting enzyme in prostaglandin (PG) biosynthesis, is often...
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15-Hydroxyprostaglandin Dehydrogenase in Colorectal Mucosa as a Potential Biomarker for Predicting Colorectal Neoplasms

Lee HJ, Yang DH, Ryu YM, Song M, Song HJ, Jung KW, Kim KJ, Ye BD, Byeon JS, Choi EK, Yang SK, Kim JH, Myung SJ

15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is downregulated during the early stages of colorectal carcinogenesis. The aim of the present study was to investigate the potential role of 15-PGDH in normal-appearing colorectal mucosa...
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