- Prognostic Implication of 15-Hydroxyprostaglandin Dehydrogenase Down-Regulation in Patients with Colorectal Cancer
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Kang PS, Kim JH, Moon OI, Lim SC, Kim KJ
- KMID: 2198689
- J Korean Soc Coloproctol.
- 2012 Oct;28(5):253-258.
- doi: 10.3393/jksc.2012.28.5.253
PURPOSE: Prostaglandin (PG) E2 is known to be closely related to cancer progression and is inactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). 15-PGDH is shown to have tumor suppressor activity and to... -
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- Decreased Expression of 15-hydroxyprostaglandin Dehydrogenase in Gastric Carcinomas
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Jang TJ, Ji YS, Jung KH
- KMID: 1782939
- Yonsei Med J.
- 2008 Dec;49(6):917-922.
- doi: 10.3349/ymj.2008.49.6.917
PURPOSE: Gastric carcinoma tissues release high level of prostaglandin E2 (PGE2) when compared to non-neoplastic mucosa, and cyclooxygenase-2 (COX-2), which is the rate-limiting enzyme in prostaglandin (PG) biosynthesis, is often... -
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- 15-Hydroxyprostaglandin Dehydrogenase in Colorectal Mucosa as a Potential Biomarker for Predicting Colorectal Neoplasms
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Lee HJ, Yang DH, Ryu YM, Song M, Song HJ, Jung KW, Kim KJ, Ye BD, Byeon JS, Choi EK, Yang SK, Kim JH, Myung SJ
- KMID: 1793019
- J Korean Med Sci.
- 2013 Aug;28(8):1154-1160.
- doi: 10.3346/jkms.2013.28.8.1154
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is downregulated during the early stages of colorectal carcinogenesis. The aim of the present study was to investigate the potential role of 15-PGDH in normal-appearing colorectal mucosa... -
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- Role of 15-hydroxyprostaglandin dehydrogenase down-regulation on the prognosis of hepatocellular carcinoma
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Yang JE, Park E, Lee HJ, Kang HJ, Kim KM, Yu E, Lee D, Shim JH, Lim YS, Lee HC, Chung YH, Lee YS
- KMID: 1737596
- Clin Mol Hepatol.
- 2014 Mar;20(1):28-37.
- doi: 10.3350/cmh.2014.20.1.28
BACKGROUND/AIMS: The role of prostaglandin E2 (PGE2) in the modulation of cell growth is well established in colorectal cancer. The aim of this study was to elucidate the significance of... -
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- Role of Prostaglandins in Colon Cancer
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Myung SJ, Kim IH
- KMID: 1767526
- Korean J Gastroenterol.
- 2008 May;51(5):274-279.
Colon cancer is one of the major leading causes of cancer-related deaths in the Western countries. In Korea, the incidence of colon cancer is increasing due to changes in environment... -
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- Impacts of Cytosolic Phospholipase A2, 15-Prostaglandin Dehydrogenase, and Cyclooxygenase-2 Expressions on Tumor Progression in Colorectal Cancer
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Lim SC, Cho H, Lee TB, Choi CH, Min YD, Kim SS, Kim KJ
- KMID: 1071420
- Yonsei Med J.
- 2010 Sep;51(5):692-699.
- doi: 10.3349/ymj.2010.51.5.692
PURPOSE: In addition to cyclooxygenase-2 (COX-2) which is related to prostaglandin E2 synthesis, other enzymes such as cytosolic phospholipase A2 (cPLA2), microsomal prostaglandin E2 synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH)... -
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