- Prediction of the human in vivo antiplatelet effect of S- and R-indobufen using population pharmacodynamic modeling and simulation based on in vitro platelet aggregation test
-
Noh YH, Han S, Choe S, Jung JA, Jung JA, Hwang AK, Lim HS
- KMID: 2429511
- Transl Clin Pharmacol.
- 2018 Dec;26(4):160-165.
- doi: 10.12793/tcp.2018.26.4.160
Indobufen (Ibustrin®), a reversible inhibitor of platelet aggregation, exists in two enantiomeric forms in 1:1 ratio. Here, we characterized the anti-platelet effect of S- and R-indobufen using response surface modeling... -
- CITED
-
- Close
- SHARE
-
- Close
- Development of a validated liquid chromatography-tandem mass spectrometry assay for the quantification of simvastatin acid, the active metabolite of simvastatin, in human plasma
-
Park HJ, Hwang AK, Kim AR, Kim SH, Kim EH, Cho SH, Ghim JL, Choe S, Jung JA, Jin SJ, Bae KS, Lim HS
- KMID: 2383596
- Transl Clin Pharmacol.
- 2016 Mar;24(1):22-29.
- doi: 10.12793/tcp.2016.24.1.22
Simvastatin is a lipid-lowering drug that is metabolized to its active metabolite simvastatin acid (SA). We developed and validated a sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to quantitate SA... -
- CITED
-
- Close
- SHARE
-
- Close
