- The Role of Adrenergic and Cholinergic Receptors on the Antinociception of Intrathecal Zaprinast in the Formalin Test of Rats
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Yoon SJ, Kim YO, Huang LJ, Cui JH, Heo BH, Jeong ST, Yoon MH
- KMID: 2238303
- Korean J Anesthesiol.
- 2007 Jul;53(1):85-90.
- doi: 10.4097/kjae.2007.53.1.85
BACKGROUND: Spinal zaprinast, phospodiesterase inhibitor, has been shown to have an antinociception through an increase of cGMP. The aim of this study was to examine the role of spinal adrenergic... -
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- Effect of Intrathecal Epigallocatechin-3-gallate on Formalin-induced Pain Rat Model
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Yoon MH, Lee HK, Kim WM, Lee MK, Kim YO, Huang LJ
- KMID: 2045758
- Chonnam Med J.
- 2008 Aug;44(2):104-108.
- doi: 10.4068/cmj.2008.44.2.104
Green tea is being widely consumed as a health beverage. Recently, green tea polyphenols have been shown to possess potent anti-inflammatory property by inhibiting the production of prostaglandins; in particular,... -
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- The Role of Opioid Receptor on the Analgesic Action of Intrathecal Sildenafil in Rats
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Lee HG, Jeong CY, Yoon MH, Kim WM, Shin SH, Kim YO, Huang LJ, Cui JH
- KMID: 2278035
- Korean J Pain.
- 2007 Jun;20(1):21-25.
- doi: 10.3344/kjp.2007.20.1.21
BACKGROUND: Intrathecal sildenafil has produced antinociception by increasing the cGMP through inhibition of phosphodiesterase 5. Spinal opioid receptor has been reported to be involved in the modulation of nociceptive transmission.... -
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- GABAB Receptor Modulation on the Antinociception of Intrathecal Sildenafil in the Rat Formalin Test
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Kim WM, Yoon MH, Lee HG, Han YG, Kim YO, Huang LJ, Cui JH
- KMID: 2278049
- Korean J Pain.
- 2007 Dec;20(2):106-110.
- doi: 10.3344/kjp.2007.20.2.106
BACKGROUND: A phosphodiesterase 5 inhibitor, sildenafil, has been effective against nociception. Several lines of evidence have demonstrated the role of the GABAergic pathway in the modulation of nociception. The impact... -
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- Effect of Intrathecal Ginsenosides on Mechanical Allodynia in a Neuropathic Rat Model
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Yoon MH, Lee HK, Kim WM, Park JH, Kim YO, Huang LJ
- KMID: 2263303
- Anesth Pain Med.
- 2008 Jul;3(3):205-209.
BACKGROUND: Traditionally, ginseng has been widely used to manage various types of diseases. In particular, the analgesic effect of ginsenosides has been reported for inflammatory pain. However, the effect of... -
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- The Role of Adrenergic and Cholinergic Receptors on the Antinociception of Korean Red Ginseng in the Spinal Cord of Rats
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Kim SY, Yoon MH, Lee HG, Kim WM, Lee JD, Kim YO, Huang LJ, Cui JH
- KMID: 1480642
- Korean J Pain.
- 2008 Apr;21(1):27-32.
- doi: 10.3344/kjp.2008.21.1.27
BACKGROUND: Experimental evidence indicates that ginseng modulate the nociceptive transmission. Authors examined the role of adrenergic and cholinergic receptors on the antinociceptive action of Korean red ginseng against the formalin-induced... -
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- The Effect of Treatment with Intrathecal Ginsenosides in a Rat Model of Postoperative Pain
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Shin DJ, Yoon MH, Lee HG, Kim WM, Park BY, Kim YO, Huang LJ, Cui JH
- KMID: 2278048
- Korean J Pain.
- 2007 Dec;20(2):100-105.
- doi: 10.3344/kjp.2007.20.2.100
BACKGROUND: Ginseng has been used to manage various types of pain in folk medicine. This study characterized the effect of treatment with intrathecal ginsenosides, the active components of ginseng in... -
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- Additive Antinociception between Intrathecal Sildenafil and Morphine in the Rat Formalin Test
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Yoon MH, Park KD, Lee HG, Kim WM, An TH, Kim YO, Huang LJ, Hua CJ
- KMID: 1107530
- J Korean Med Sci.
- 2008 Dec;23(6):1033-1038.
- doi: 10.3346/jkms.2008.23.6.1033
The possible characteristics of spinal interaction between sildenafil (phosphodiesterase 5 inhibitor) and morphine on formalin-induced nociception in rats was examined. Then the role of the opioid receptor in the effect... -
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- Effect of Sildenafil on Neuropathic Pain and Hemodynamics in Rats
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Huang LJ, Yoon MH, Choi JI, Kim WM, Lee HG, Kim YO
- KMID: 1779610
- Yonsei Med J.
- 2010 Jan;51(1):82-87.
- doi: 10.3349/ymj.2010.51.1.82
PURPOSE: The inhibition of phosphodiesterase 5 produces an antinociception through the increase of cyclic guanosine monophosphate (cGMP), and increasing cGMP levels enhance the release of gamma-aminobutyric acid (GABA). Furthermore, this... -
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