- Reversal of liver cirrhosis: current evidence and expectations
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Jung YK, Yim HJ
- KMID: 2371643
- Korean J Intern Med.
- 2017 Mar;32(2):213-228.
- doi: 10.3904/kjim.2016.268
In the past, liver cirrhosis was considered an irreversible phenomenon. However, many experimental data have provided evidence of the reversibility of liver fibrosis. Moreover, multiple clinical studies have also shown... -
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- The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration
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Lua I, Asahina K
- KMID: 2363962
- Gut Liver.
- 2016 Mar;10(2):166-176.
- doi: 10.5009/gnl15226
Mesothelial cells (MCs) cover the surface of visceral organs and the parietal walls of cavities, and they synthesize lubricating fluids to create a slippery surface that facilitates movement between organs... -
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- The Expression of G1 Cycins and Rb-E2F, and the Effect of Vitamin E on Hepatic Stellate Cells Activated by CCl4
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Lee KJ, Lee KS, Hahn KH, Chon CY, Moon YM, Oh SH, Kim HK
- KMID: 2304589
- Korean J Gastroenterol.
- 2001 Oct;38(4):262-269.
BACKGROUND/AIMS: It is obscure when the activation of hepatic stellate cells and the expression of its related factors occur in acute liver injury. Vitamin E is expected to prevent hepatic... -
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- Experimental Animal Models of Hepatic Fibrosis
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Lee KS
- KMID: 1598583
- Korean J Gastroenterol.
- 2001 Apr;37(4):227-232.
Excessive production of extracellular matrix(ECM), especially collagen, in the liver can produce hepatic fibrosis, and the repeated hepatic fibrosis by various etiologies may result in liver cirrhosis. Liver cirrhosis is... -
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- Pathophysiology and diagnosis of portal hypertension
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Kim MY
- KMID: 2256156
- Korean J Med.
- 2008 Jul;75(1):1-5.
Portal hypertension (PHT) as a consequence of liver cirrhosis is responsible for serious complications such as variceal bleeding, ascites and hepatic encehphalopathy. PHT is caused by increased intrahepatic vascular resistance... -
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- Involvement of Hepatic Innate Immunity in Alcoholic Liver Disease
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Byun JS, Jeong WI
- KMID: 2150673
- Immune Netw.
- 2010 Dec;10(6):181-187.
- doi: 10.4110/in.2010.10.6.181
Excessive alcohol consumption is one of the critical causative factors leading to alcoholic liver disease (ALD). ALD is characterized by a wide spectrum of liver damage, ranging from simple uncomplicated... -
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- Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase
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Iwakiri Y
- KMID: 2359812
- Clin Mol Hepatol.
- 2015 Dec;21(4):319-325.
- doi: 10.3350/cmh.2015.21.4.319
The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could... -
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- Protective Effect of Pentoxifylline and Ciprofloxacin on Dimethylnitrosamine-induced Hepatic Fibrosis in Rats
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Suh KS, Lee CH, Sol MY, Lee SK
- KMID: 2241262
- Korean J Hepatol.
- 2001 Mar;7(1):34-46.
BACKGROUND/AIMS: Hepatic fibrosis is known to be a predisposing condition of cirrhosis for which there is no proven effective therapy. The aim of this study was to investigate the effect... -
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- NADPH oxidase mediated oxidative stress in hepatic fibrogenesis
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Paik YH, Brenner DA
- KMID: 1792602
- Korean J Hepatol.
- 2011 Dec;17(4):251-257.
- doi: 10.3350/kjhep.2011.17.4.251
NADPH oxidase (NOX) is a multicomponent enzyme complex that generates reactive oxygen species (ROS) in response to a wide range of stimuli. ROS is involved as key secondary messengers in... -
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- Immunohistochemical Reaction of Hepatic Stellate Cells in Dimethylnitrosamine-induced Rat Liver Damage
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Son HI, Lee CH, Suh KS
- KMID: 1548545
- Korean J Gastroenterol.
- 1999 Oct;34(4):479-488.
BACKGROUND/AIMS: Hepatic stellate cell (HSC) is the major source of extracellular matrix in the liver. The purpose of this study was to evaluate the pattern of immunocytochemical expression in HSC... -
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- The Natural Killer Cell Response to HCV Infection
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Ahlenstiel G
- KMID: 1493610
- Immune Netw.
- 2013 Oct;13(5):168-176.
- doi: 10.4110/in.2013.13.5.168
In the last few years major progress has been made in better understanding the role of natural killer (NK) cells in hepatitis C virus (HCV) infection. This includes multiple pathways... -
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- Bone Marrow Stem Cells Anti-liver Fibrosis Potency: Inhibition of Hepatic Stellate Cells Activity and Extracellular Matrix Deposition
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Sitanggang EJ, Antarianto RD, Jusman SW, Pawitan JA, Jusuf AA
- KMID: 2384603
- Int J Stem Cells.
- 2017 May;10(1):69-75.
- doi: 10.15283/ijsc16048
Transplantation of bone marrow derived stem cells (BMSCs) has been reported inhibits liver fibrosis. Several in vitro studies by co-culturing BMSCs and hepatic stellate cells (HSCs) indirectly or directly in... -
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- Pathophysiology of Portal Hypertension, What's New?
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Kim MY, Baik SK
- KMID: 948775
- Korean J Gastroenterol.
- 2010 Sep;56(3):129-134.
- doi: 10.4166/kjg.2010.56.3.129
Portal hypertension (PHT) is associated with changes in the intrahepatic, systemic and portosystemic collateral circulations. Alteration in vasoreactivity (vasodilation and vasoconstriction) plays a central role in the pathogenesis of PHT... -
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- Establishment of Human Myofibroblast Like Cell Line Immortalized by Transfection of SV40 Largw T Gene
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Kim CY, Lee HS, Jun HS, Woo GH, Yoon JH, Lee JS
- KMID: 2084956
- Korean J Gastroenterol.
- 1999 Sep;34(3):345-356.
BACKGROUND/AIMS: Myofibroblast like cell (MFLC) plays an important role in hepatic fibrogenesis. A continuously proliferating human MFLC line would be valuable in studying human hepatic fibrogenesis. The present study was... -
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- Management of Diabetes in Liver Cirrhosis
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Kim JH
- KMID: 2354279
- J Korean Diabetes.
- 2016 Sep;17(3):159-163.
- doi: 10.4093/jkd.2016.17.3.159
Diabetes mellitus (DM) is common in patients with liver cirrhosis, indicating a bidirectional relationship between DM and liver cirrhosis. Type 2 DM is a risk factor for development and progression... -
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- Inhibition of hepatic stellate cells by bone marrow-derived mesenchymal stem cells in hepatic fibrosis
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Jang YO, Jun BG, Baik SK, Kim MY, Kwon SO
- KMID: 2164364
- Clin Mol Hepatol.
- 2015 Jun;21(2):141-149.
- doi: 10.3350/cmh.2015.21.2.141
BACKGROUND/AIMS: Therapies involving bone-marrow-derived mesenchymal stem cells (BM-MSCs) have considerable potential in the management of hepatic disease. BM-MSCs have been investigated in regenerative medicine due to their ability to secrete... -
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- Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model
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Kim IH, Kim SW, Kim SH, Lee SO, Lee ST, Kim DG, Lee MJ, Park WH
- KMID: 1397449
- Exp Mol Med.
- 2012 Jul;44(7):448-456.
Parthenolide (PT), a sesquiterpene lactone derived from the plant feverfew, has pro-apoptotic activity in a number of cancer cell types. We assessed whether PT induces the apoptosis of hepatic stellate... -
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- Definition, Pathogenesis, and Natural Progress of Non-alcoholic Fatty Liver Disease
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Jeon JH, Park KG
- KMID: 2173896
- J Korean Diabetes.
- 2014 Jun;15(2):65-70.
- doi: 10.4093/jkd.2014.15.2.65
Non-alcoholic fatty liver disease (NAFLD) is emerging as a world-wide health problem and is currently recognized as a hepatic manifestation of metabolic syndrome. It is an umbrella term to describe... -
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- The Effects of High Glucose, Insulin and TGF-beta 1 on Proliferation and Differentiation of the Pancreatic Stellate Cells
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Hong OK, Kwon HS, Yeom KH, Lee M, Yang JH, Ko SH, Yoo SJ, Son HS, Yoon KH, Cha BY, Lee KW, Son HY, Kang SK
- KMID: 1768000
- J Korean Diabetes Assoc.
- 2003 Jun;27(3):228-240.
BACKGROUND: Although chronic pancreatitis gives rise to fibrosis of pancreatic exocrine tissue, and type 2 diabetes is accompanied by pancreatic fibrosis, the mechanisms of fibrogenesis in the pancreas have been... -
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- Transcriptional Regulation of Hepatic Stellate Cell Activation by siRNA for TGF-beta1
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Oh HK, Kim KH, Keum YS, Cho CH, Park JB, Park KK
- KMID: 1472634
- Korean J Pathol.
- 2009 Dec;43(6):503-508.
- doi: 10.4132/KoreanJPathol.2009.43.6.503
BACKGROUND: The cytokine-induced activation of hepatic stellate cells (HSC) plays a major role in liver fibrosis. Quiescent HSCs undergo phenotypic transformation called "transdifferentiation" in response to viral, chemical or immune... -
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