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The Relationship between the Popular Beverages in Korea and Reported Postprandial Heartburn

Kim YK, Moon JS, Ryu SH, Lee JH, Kim YS

BACKGROUND/AIMS: The aim of this study was to investigate the frequency of heartburn produced by beverages available in Korea and to clarify the mechanism causing heartburn. METHODS: We measured pH, titratable...
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Is Gastroesophageal Reflux Disease and Achalasia Coincident or Not?

Jung DH, Park H

  • KMID: 2367449
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):5-8.
  • doi: 10.5056/jnm16121
Achalasia and gastroesophageal reflux disease (GERD) are on opposite ends of the spectrum of lower esophageal sphincter dysfunction. Heartburn is the main symptom of GERD. However, heartburn and regurgitation are...
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Reflux Hypersensitivity: A New Functional Esophageal Disorder

Yamasaki T, Fass R

  • KMID: 2395417
  • J Neurogastroenterol Motil.
  • 2017 Oct;23(4):495-503.
  • doi: 10.5056/jnm17097
Reflux hypersensitivity, recently introduced by Rome IV as a new functional esophageal disorder, is currently considered as the presence of typical heartburn symptoms in patients with normal upper endoscopy and...
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The significance of esophageal motility disorder as the cause of heartburn and/or chest pain in Korea

Kim NY, Youn SJ, Roe IH, Kim YT, Choi SW, Jung HC, Yoon YB, Song IS, Choi KW, Kim CY

  • KMID: 1685249
  • Korean J Gastroenterol.
  • 1991 Feb;23(1):1-11.
No abstract available.
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Understanding the Rome IV: Esophageal Disorders

Park MI

The Rome IV criteria, published in 2016, encompass upper gastrointestinal lesions of functional esophageal disorders and functional gastroduodenal disorders. Functional esophageal disorders include functional chest pain, functional heartburn, reflux hypersensitivity,...
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Prevalence of gastroesophageal reflux in routine check-up subjects

Jeon SG, Sohn CI, Kim JE, Park KH, Whang IS, Kim EJ, Park CY, Kim BI, Jeon WG, Chung ES, Rhee PL, Choi KW, Lee WY

  • KMID: 2306230
  • Korean J Med.
  • 2000 Feb;58(2):145-151.
BACKGROUND: Gastroesophageal reflux disease (GERD) is considered to be less common in the Orient compared to the West, but epidemiological data on GERD in Korea are rare. The aim of this study...
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Esophageal Sensation and Esophageal Hypersensitivity: Overview From Bench to Bedside

Miwa H, Kondo T, Oshima T, Fukui H, Tomita T, Watari J

  • KMID: 2204231
  • J Neurogastroenterol Motil.
  • 2010 Oct;16(4):353-362.
Noxious stimuli in the esophagus activate nociceptive receptors on esophageal mucosa, such as transient receptor potential, acid-sensing ion channel and the P2X family, a family of ligand-gated ion channels responsive...
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Prospective Single Arm Study on the Effect of Ilaprazole in Patients with Heartburn but No Reflux Esophagitis

Song IJ, Kim HK, Lee NK, Lee SK

PURPOSE: Patients with gastroesophageal reflux disease without esophagitis show varying responses to proton pump inhibitors (PPIs). The aim of this study was to objectively evaluate the effect of a new...
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Role of Esophageal Mean Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Discriminating Chinese Patients With Heartburn

Sun YM, Gao Y, Gao F

  • KMID: 2460480
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):515-520.
  • doi: 10.5056/jnm19056
BACKGROUND/AIMS: Recently, esophageal mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index have been proposed, which can increase the diagnostic role of multichannel intraluminal impedance and pH...
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Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Dickman R, Maradey-Romero C, Gingold-Belfer R, Fass R

  • KMID: 2433470
  • J Neurogastroenterol Motil.
  • 2015 Jul;21(3):309-319.
  • doi: 10.5056/jnm15105
Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements...
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A More In-depth Evaluation of Impedance-pH Could Assist in Distinguishing Reflux-related From Reflux-unrelated Heartburn

de Bortoli N, Furnari M, Tolone S, Savarino E

  • KMID: 2381313
  • J Neurogastroenterol Motil.
  • 2015 Oct;21(4):621-622.
  • doi: 10.5056/jnm15085
No abstract available.
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Current Trends in the Management of Gastroesophageal Reflux Disease

Sandhu DS, Fass R

Gastroesophageal reflux disease (GERD) characterized by heartburn and/or regurgitation symptoms is one of the most common gastrointestinal disorders managed by gastroenterologists and primary care physicians. There has been an increase...
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Cough related to swallowing in asthma patients

Kamimura M, Mouri A, Takayama K, Mizutani T, Hamamoto Y, Iikura M, Furihata K

BACKGROUND: Occurrence of cough during swallowing is common among asthma patients, but has not been investigated in detail. OBJECTIVE: We conducted an observational study to determine the prevalence of swallowing-related cough...
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The Clinical Spectrum of Gastroesophagel Reflux Disease in Korea

Lee SH, Choi MG, Park SH, Choi H, Moon SB, Choo KY, Wang JH, Kim JK, Choi KY, Chung KW, Sun HS

  • KMID: 2305008
  • Korean J Gastrointest Motil.
  • 2000 Jun;6(1):1-10.
BACKGROUND/AIM: Heartburn, which was the most common symptom of reflux disease, was unreliably interpreted by Korean patients. Our aim was to evaluate the clinical spectrum of gastroesophageal reflux disease(GERD) in...
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Clinical Characteristics of Patients with Untreated Achalasia

Jeon HH, Kim JH, Youn YH, Park H, Conklin JL

  • KMID: 2387828
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):378-384.
  • doi: 10.5056/jnm16177
BACKGROUND/AIMS: Patients with untreated achalasia frequently complain of heartburn and regurgitation. The diagnosis of achalasia might be delayed because these symptoms are misinterpreted as gastroesophageal reflux. We aim to evaluate...
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Prevalence, Clinical Manifestations, and Treatment of Gastroesophageal Reflux Disease in Korea

Jeon SG, Rhee PL

  • KMID: 2143719
  • Korean J Gastroenterol.
  • 2002 Jun;39(6):393-401.
Gastroesophageal reflux disease (GERD) is characterized by the presence of esophageal mucosal injury or by the occurrence of reflux-induced symptoms which are severe enough to impair quality of life. GERD...
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The Relationship of the Post-reflux Swallow-induced Peristaltic Wave Index and Esophageal Baseline Impedance with Gastroesophageal Reflux Disease Symptoms

Cho YK, Lee JS, Lee TH, Hong SJ, Park SJ, Jeon SR, Kim HG, Kim JO

  • KMID: 2433524
  • J Neurogastroenterol Motil.
  • 2017 Apr;23(2):237-244.
  • doi: 10.5056/jnm16115
BACKGROUND/AIMS: The post-reflux swallow-induced peristaltic wave (PSPW) index and esophageal baseline impedance (BI) are novel impedance parameters used to evaluate esophageal chemical clearance and mucosal integrity. However, their relationship with...
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Effect of Camostat Mesilate in the Treatment of Reflux Esophagitis after Gastrectomy

Lee KU, Lee KY, Han SH

  • KMID: 2128644
  • Korean J Gastroenterol.
  • 1998 Mar;31(3):275-280.
BACKGROUND AND AIMS: Reflux esophagitis is one of common complications appeared after gastric surgeries. Bile reflux is considered as an important mechanism. Recently, reflux of pancreatic juice is also suggested...
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Inconsistency in the Diagnosis of Functional Heartburn: Usefulness of Prolonged Wireless pH Monitoring in Patients With Proton Pump Inhibitor Refractory Gastroesophageal Reflux Disease

Penagini R, Sweis R, Mauro A, Domingues , Vales A, Sifrim D

  • KMID: 2381258
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):265-272.
  • doi: 10.5056/jnm14075
BACKGROUND/AIMS: The diagnosis of functional heartburn is important for management, however it stands on fragile pH monitoring variables, ie, acid exposure time varies from day to day and symptoms are...
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Generation of Gastroesophageal Reflux Disease Symptoms During Esophageal Acid Infusion With Concomitant Esophageal pH Monitoring in Healthy Adults

Ohara S, Furuta K, Adachi K, Fukazawa K, Aimi M, Miki M, Kinoshita

  • KMID: 2325771
  • J Neurogastroenterol Motil.
  • 2013 Oct;19(4):503-508.
BACKGROUND/AIMS: The sensitivity of the upper and lower esophageal mucosa to acid is considered to differ. We investigated the relationship between pH changes in different sites of the esophagus and...
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