- Effect of Furosemide on the Renal Guanylate Cyclase in Rat
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Kim HS, Chun CS
- KMID: 1912430
- Korean J Urol.
- 1987 Aug;28(4):488-494.
Furosemide acts primarily on the thick ascending limb of the loop of Henle and inhibits the chloride transport in this site, which is the main mechanism of diuretic action of... -
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- Acute cyclosporin A-treatment impairs the cytosolic guanylate cyclase-mediated vasodilatation in rat thoracic aorta
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Kook H
- KMID: 2285210
- Korean J Physiol Pharmacol.
- 1998 Aug;2(4):471-477.
Cyclosporin A (CsA), a widely used immunosuppressant, is well known to cause nephrotoxicity and hypertension as major side effects. The present study was aimed at investigating the effects of CsA-pretreatment on the activities... -
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- Restoration of Blood Pressure after Administering Methylene Blue for Vasoplegic Syndrome, which Developed after Open Heart Surgery for Septic Infective Endocarditis: A case report
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Lee S, Bae MK, Yi GJ, Youn YN, Song SW, Kim DK
- KMID: 1916511
- Korean J Thorac Cardiovasc Surg.
- 2007 Apr;40(4):305-308.
Vasoplegic syndrome occurs in 8~10% of patients following cardiac surgery, and this happens in part because of inducing the inflammatory response. Nitric oxide and guanylate cyclase play an important role... -
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- Effects of Nitric Oxide on Cytochrome P450SCC Activity in Adrenal Cortical Cells
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Jung K, Kang CG, Choi IS, Lee KY
- KMID: 2172302
- Chonnam Med J.
- 2005 Dec;41(3):237-242.
Nitric oxide (NO) modulates steroid hormone synthesis. However, the precise mechanism of the inhibitory action of NO on the hormone synthesis is not well clarified. Synthesis of pregnenolone from cholesterol... -
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- Methylene Blue for Vasoplegic Syndrome after Cardiopulmonary Bypass: A case report
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Lee JY, Lee MH, Lee JW
- KMID: 1763526
- Korean J Anesthesiol.
- 2008 Jun;54(6):677-681.
- doi: 10.4097/kjae.2008.54.6.677
Vasoplegic syndrome (VS) occurs in 8-10% of patients following cardiac surgery and is associated with increased morbidity and mortality. Nitric oxide and guanylate cyclase play an important role in this... -
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- Effects of Nitric Oxide on the Maturation of Mouse Oocyte in vitro
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Kim JL, Lee KY, Park HJ, Kwon YS, Lee YI
- KMID: 2075948
- Korean J Obstet Gynecol.
- 1999 Nov;42(11):2542-2548.
OBJECTIVE: Nitric oxide (NO) produced in ovary may contribute to follicle maturation, ovulation, oocyte maturation and luteinization. In this study, the effect of nitric oxide on the spontaneous maturation of... -
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- The hyperthermic effect of nitric oxide in central nervous system
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Jung JK, Sohn UD, Lee SY
- KMID: 1606844
- Korean J Physiol Pharmacol.
- 2001 Feb;5(1):93-98.
The precise mechanism of set-point regulation in hypothalamus was not elucidated. Nitric oxide synthases (NOS) were detected in hypothalamus, however, the roles of NO in hypothalamus was not fully studied. So, we tested... -
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- Inhibition of Hypoxic Pulmonary Vasoconstriction of Rats by Carbon Monoxide
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Yoo HY, Park SJ, Bahk JH, Kim SJ
- KMID: 2157842
- J Korean Med Sci.
- 2010 Oct;25(10):1411-1417.
- doi: 10.3346/jkms.2010.25.10.1411
Hypoxic pulmonary vasoconstriction (HPV), a unique response of pulmonary circulation, is critical to prevent hypoxemia under local hypoventilation. Hypoxic inhibition of K+ channel is known as an important O2-sensing mechanism... -
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- Effect of Carbon Monoxide on the Relaxtion of the Rabbit Corpus Corpus Cavernosal Smooth uscle
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Rha KH, Choi YD, Choi HK, Lee MS
- KMID: 2292441
- Korean J Urol.
- 2001 Jan;42(1):23-31.
PURPOSE: Carbon monoxide (CO) is produced during the degradation of hemoglobin to heme (iron protoporphyrin) and present in various tissues including brain. CO is believed to activate soluble guanylate cyclase... -
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- Alteration of Nitric Oxide Synthase and Guanylyl Cyclase Activity in Rats with Ischemia/Reperfusion Renal Injury
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Bae EH, Kim SW
- KMID: 1587475
- Korean J Physiol Pharmacol.
- 2006 Dec;10(6):337-341.
The present study was designed to investigate the protein expression of nitric oxide synthase (NOS) and guanylyl cyclase (GC) activity in ischemia/perfusion (I/R) renal injury in rats. Renal I/R injury... -
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- Diminished vascular guanylyl cyclase activity in deoxycorticosterone acetate-salt hypertension
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Lee JU, Hong JH
- KMID: 1580935
- Korean J Physiol Pharmacol.
- 2000 Oct;4(5):379-383.
Pathophysiological implications of the vascular nitric oxide (NO)/cGMP pathway in hypertension were investigated. Sprague-Dawley rats were made deoxycorticosterone acetate (DOCA)-salt hypertensive for six weeks. The protein expression of endothelial constitutive NO synthase (ecNOS) and... -
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- Differentially-altered vascular guanylate cyclase isoforms in experimental hypertensive rats
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Lee JU, Kang DG, Kook H, Kim IK, Oh BS
- KMID: 1731311
- J Korean Med Sci.
- 1999 Aug;14(4):386-392.
- doi: 10.3346/jkms.1999.14.4.386
Pathophysiological implications of the vascular nitric oxide (NO)/cGMP pathway were investigated in various rat models of hypertension. The expression of brain and endothelial constitutive NO synthases (bNOS, ecNOS) was determined... -
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- Early Reversible Changes on ERG in Pharmaceutically Induced Retinal Degeneration in Rats
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Roh KH, Park TK, Ohn YH
- KMID: 2208439
- J Korean Ophthalmol Soc.
- 2006 Jul;47(7):1117-1125.
PURPOSE: To evaluate the early ERG (electroretinogram) changes in N-methyl-N-nitrosourea (MNU)-induced retinal degeneration in rats. METHODS: Thirty-six 6-week-old male rats were injected intraperitoneally with 60mg/kg MNU and divided into 6 groups.... -
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- The effects of oxygen radicals on the activity of nitric oxide synthase and guanylate cyclase
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Kim SM, Byun JS, Jung YD, Kang IC, Choi SY, Lee KY
- KMID: 755012
- Exp Mol Med.
- 1998 Dec;30(4):221-226.
Reactive oxygen species such as superoxides, hydrogen peroxide (H2O2) and hydroxyl radicals have been suggested to be involved in the catalytic action of nitric oxide synthase (NOS) to produce NO... -
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- Regulatory role of cyclic nucleotides in non-adrenergic non-cholinergic relaxation of lower esophageal sphincter from dogs
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Kim YT, Rhim BY
- KMID: 2285174
- Korean J Physiol Pharmacol.
- 1997 Jun;1(3):303-313.
The role of the lower esophageal sphincter (LES) is characterized by the ability to maintain tone and to relax allowing the passage of a bolus. It is known that LES relaxation during... -
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- The Vascular Effect of Ketamine Hydrochloride on The Isolated Rabbit Pulmonary ArteryC
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Lee SH, Suh JK, Chon SU
- KMID: 2240493
- Korean J Anesthesiol.
- 1994 Oct;27(10):1237-1245.
- doi: 10.4097/kjae.1994.27.10.1237
Ketamine hydrochloride is a phencyclidine derivatives and dissociative anesthetics. Ketamine induce the pulmonary vasoconetrietion in vivo. This study was designed to deter- mine the direct effect of the ketamine on... -
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- Lipopolysaccharide inhibits proliferation of the cultured vascular smooth muscle cells by stimulating inducible nitric oxide synthase and subsequent activation of guanylate cyclase
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Choi HC, Lee SG, Kim JH, Kim JY, Sohn UD, Ha JH, Lee KY, Kim WJ
- KMID: 2071574
- Korean J Physiol Pharmacol.
- 2001 Aug;5(4):343-351.
This study was undertaken to investigate the mechanism of lipopolysaccharide (LPS) and nitric oxide (NO) as a regulator of vascular smooth muscle cell (VSMC) proliferation. VSMC was primarily cultured from rat aorta and... -
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- Altered Gene Expression in Cerulein-Stimulated Pancreatic Acinar Cells: Pathologic Mechanism of Acute Pancreatitis
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Yu JH, Lim JW, Kim H
- KMID: 2285374
- Korean J Physiol Pharmacol.
- 2009 Dec;13(6):409-416.
- doi: 10.4196/kjpp.2009.13.6.409
Acute pancreatitis is a multifactorial disease associated with the premature activation of digestive enzymes. The genes expressed in pancreatic acinar cells determine the severity of the disease. The present study... -
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- Effect of Guanylate Cyclase Inhibition on the Concentration of Nitrite in Culture Medium of Vascular Smooth Muscle Cell
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Jo HC, Jang NS, Rhee JA, Kim SY, Choi HC, Lee KY, Kim WJ
- KMID: 2096762
- J Korean Soc Vasc Surg.
- 1999 Nov;15(2):186-194.
PURPOSE: Nitric oxide (NO) exerts the relaxant effect in vascular smooth muscle cells (VSMC) by activating soluble guanylate cyclase (sGC), which produces cyclic guanidine monophosphate (cGMP) in the cell. This... -
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- Effects of Nitric Oxide on Voltage-dependent Potassium Currents in Vestibular Nuclear Neuron of the Rat
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Jeong HS, Lee GO, Kim JH, Heo T, Moon JY, Park JS
- KMID: 1807454
- Chonnam Med J.
- 2000 Jun;36(2):129-138.
The effect of the nitrix oxide (NO) pathway on voltage-dependent potassium currents in rat vestibular nuclear neurons was investigated by using the whole cell patch clamp technique. When cells were... -
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