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Improved outcome in childhood ALL with intensive consolidation and hematopoietic stem cell transplant

Park JA, Ghim T, Bae KW, Koh KN, Im HJ, Seo JJ

BACKGROUND: Despite advances in chemotherapy, the prognosis of relapsed acute lymphoblastic leukemia (ALL) remains poor. Few studies on relapsed ALL have reported the importance of intensive consolidation followed with or...
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Hereditary Hemolytic Anemia in Korea: a Retrospective Study from 1997 to 2006

Cho HS, Hah JO, Kang IJ, Kang HJ, Kwak JY, Koo HH, Kook H, Kim BK, Kim SK, Kim ST, Kim YD, Kim JY, Kim CS, Ghim T, Kim HS, Park SG, Park SY, Park JE, Bang SM, Seo JJ, Suh CI, Sohn SK, Shin HJ, Shin HY, Ahn HS, Oh D, Yoo ES, Lyu CJ, Yoon SS, Lee KS, Lee KC, Lee KH, Lee SY, Lee YH, Lee JA, Lee JS, Lim YT, Lim JY, Im HJ, Jeong DC, Chong SY, Chung JS, Jung HL, Cho GJ, Jo DY, Jin JY, Choi EJ, Hyun MS, Hwang PH

BACKGROUND: The aim of this study was to investigate the prevalence, clinical and laboratory findings of hereditary hemolytic anemia (HHA) in Korea from 1997 to 2006 and to develop the...
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Current Status of Hematopoietic Stem Cell Transplantation in Korean Children

Jeong DC, Kang HJ, Koo HH, Kook H, Kim SY, Kim SK, Ghim T, Kim HK, Kim HM, Moon HN, Park KD, Park BK, Park SG, Park YS, Park HJ, Seo JJ, Sung KW, Shin HY, Ahn HS, Ryu KH, Ryu KH, Yoo ES, Lyu CJ, Lee KC, Lee SY, Lee YH, Lim YT, Lim JY, Jang PS, Jeon IS, Chung NG, Cho B, Hah JO, Hwang PH, Hwang TJ

BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is one of the most important armamentarium against various hematologic malignancies or some solid tumors. We investigated the number of patients who might need...
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Prophylactic Low-dose Heparin or Prostaglandin E1 may Prevent Severe Veno-occlusive Disease of the Liver after Allogeneic Hematopoietic Stem Cell Transplantation in Korean Children

Song JS, Seo JJ, Moon HN, Ghim T, Im HJ

Studies investigating the effect of prophylactic drugs on hepatic veno-occlusive disease (VOD) development are rare in children that have undergone allogeneic hematopoietic stem cell transplantation (HSCT). This study examined risk...
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Treatment Outcome and Prognostic Factors for Children with Advanced Non-Hodgkin's Lymphoma at a Single Institution

Song JS, Youn HS, Im HJ, Ghim T, Moon HN, Seo JJ

BACKGROUND: Non-Hodgkin's lymphoma (NHL) accounts for over 80% of pediatric malignant lymphoma in Korea; the event free survival (EFS) of advanced stage NHL has been reported to be 60 to...
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Prognostic Significance of Multidrug Resistance Gene 1 (MDR1), Multidrug Resistance-related Protein (MRP) and Lung Resistance Protein (LRP) mRNA Expression in Acute Leukemia

Huh HJ, Park CJ, Jang S, Seo EJ, Chi HS, Lee JH, Lee KH, Seo JJ, Moon HN, Ghim T

The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression...
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Hemophagocytic Syndrome Presenting as Severe Acute Hepatitis

Ryu JM, Chang SH, Kim JS, Lee JH, Lee MJ, Park KY, Kim KM, Seo JJ, Moon HN, Ghim T, Chi HS

  • KMID: 2275244
  • Korean J Pediatr Gastroenterol Nutr.
  • 2005 Sep;8(2):213-221.
PURPOSE: Hemophagocytic syndrome (HPS) is characterized by persistent high fever, hepatosplenomegaly, cytopenias, hypertriglyceridemia, and/or hypofibrinogenemia. Hepatic manifestations including overt hepatic failure and fulminant hepatitis are common in HPS. Liver transplantation...
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A Case of Omenn Syndrome in a Patient Treated for Chronic Diarrhea and Severe Exfoliative Erythrodermia

Yum MS, Lee SY, Kim HB, Yoo HW, Ghim T, Hong SJ

  • KMID: 2314377
  • Pediatr Allergy Respir Dis.
  • 2005 Jun;15(2):174-179.
Omenn syndrome (OS) is a peculiar, autosomal recessive severe combined immunodeficiency (SCID) associated with early-onset, generalized, exudative erythrodermia, lymphadenopathy, hepatosplenomegaly, hypereosinophilia, elevated serum IgE, and normal to highly activated, yet...
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A Case of Systemic Castleman's Disease in a Child and Successful Treatment with Oral Prednisolone

Koo SE, Lee MJ, Kim JE, Huh JR, Ghim T

  • KMID: 2278683
  • Korean J Pediatr.
  • 2005 Apr;48(4):443-447.
Castleman's disease is a rare non-neoplastic lymphoproliferative disorder of unknown etiology. It is divided into three histologic subtypes; hyaline-vascular(HV), plasma cell(PC) type and mixed type (HV-PC). It has two clinical...
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Prognostic Significance of WT1 Gene Expression in Patients with Acute Leukemia

Huh HJ, Park CJ, Seo EJ, Chi HS, Lee JH, Lee KH, Seo JJ, Moon HN, Ghim T

  • KMID: 2038241
  • Korean J Lab Med.
  • 2005 Apr;25(2):78-84.
BACKGROUND: The Wilms' tumor gene (WT1) is located on chromosome 11p13. Several authors have shown that the expression of WT1 gene is associated with prognosis of acute leukemia. It was the...
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High Risk Medulloblastoma in Childhood: Multidisciplinary Approach and Improved Outcome

Song JS, Ra YS, Ahn SD, Khang SK, Goo HW, Kim YJ, Lee MJ, Kim YJ, Ghim T

  • KMID: 2278314
  • Korean J Pediatr Hematol Oncol.
  • 2004 Oct;11(2):187-194.
PURPOSE: Medulloblastoma is the most common malignant brain tumor in childhood. The standard treatments are composed of tumor resection, irradiation and chemotherapy. In this study, we analysed the outcome of...
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Autologous Stem Cell Transplantation for the Treatment of Neuroblastoma in Korea

Ryu KH, Ahn HS, Koo HH, Kook H, Kim MK, Kim HK, Ghim T, Moon HN, Seo JJ, Sung KW, Shin HY, Yoo ES, Lyu CJ, Lee YH, Lee H, Cho B, Cho HS, Choi HS, Hah JO, Hwang TJ

Autologous stem cell transplantation (ASCT) for the treatment of high-risk neuroblastoma (NBL) is an accepted method for restoring bone marrow depression after high dose chemotherapy. We retrospectively analyzed eighty eight...
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Technical Review of Target Volume Delineation on the Posterior Fossa Tumor:An Optimal Head and Neck Position

Yoon SM, Lee SW, Ahn SD, Kim JH, Yi BY, Ra YS, Ghim T, Choi EK

  • KMID: 2097219
  • J Korean Soc Ther Radiol Oncol.
  • 2003 Mar;21(1):94-99.
PURPOSE: To explore a 3D conformal radiotherapy technique for a posterior fossa boost, and the potential advantages of a prone position for such radiotherapy. MATERIALS AND METHODS: A CT simulator and...
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TEL/AML1 Fusion Transcripts in Childhood B-Lineage Acute Lymphoblastic Leukemia

Choi SJ, Chi HS, Park CJ, Seo EZ, Seo JJ, Ghim T, Moon HN

  • KMID: 1641954
  • Korean J Hematol.
  • 2002 Aug;37(3):169-176.
BACKGROUND: The t(12;21)(p13;q22), which fuses the TEL gene on chromosome 12p13 and the AML1 gene on chromosome 21q22, is observed in approximately 20~25% of childhood B-lineage acute lymphoblastic leukemia (ALL)...
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A Clinical Study on Hereditary Spherocytosis

Park JC, Park JE, Kim YJ, Seo JJ, Moon HN, Ghim T

  • KMID: 1979918
  • Korean J Pediatr Hematol Oncol.
  • 2000 Apr;7(1):9-15.
PURPOSE: The aim of this study was to investigate the clinical and laboratory findings of hereditary spherocytosis comparing those of different age groups. METHODS: The clinical and laboratory findings of...
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Hematologic Findings of Childhood Myelodysplastic Syndrome

Choi SJ, Park CJ, Seo EZ, Chi HS, Seo JJ, Ghim T, Moon HN

  • KMID: 1537187
  • Korean J Hematol.
  • 2000 Feb;35(1):21-26.
BACKGROUND: The myelodysplastic syndromes (MDS) in childhood is considered to be very rare and the nature of this disease in childhood is very different from that in adults. We analyzed...
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A Clinical Study on Myelodysplastic Syndrome in Childhood

Park JE, Seo JJ, Moon HN, Park CJ, Chi HS, Ghim T

  • KMID: 2278180
  • Korean J Pediatr Hematol Oncol.
  • 1999 Oct;6(2):250-258.
PURPOSE: This study was undertaken to investigate the clinical characteristics and prognostic predictors of myelodysplastic syndrome (MDS) in childhood. Method: The characteristics and laboratory findings of 20 patients seen at...
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Clinical Features of Pancreatitis in Children with Leukemia and Lymphoma

Park JE, Kim KM, Seo JJ, Moon HN, Ghim T

  • KMID: 2072475
  • Korean J Pediatr Hematol Oncol.
  • 1999 Apr;6(1):48-56.
PURPOSE: The aim of this study was to review the clinical characteristics and treatment outcome of pancreatitis developed in 19 children with leukemia and lymphoma in Asan Medical Center. METHODS:...
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