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Editor’s introduction to this issue (G&I 18:4, 2020)

Park T

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Updated confidence intervals for the COVID-19 antibody retention rate in the Korean population

Kamruzzaman M, Apio C, Park T

With the ongoing rise of coronavirus disease 2019 (COVID-19) pandemic across the globe, interests in COVID-19 antibody testing, also known as a serology test has grown, as a way to...
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Transcriptome analysis of iBET-151, a BET inhibitor alone and in combination with paclitaxel in gastric cancer cells

Kang SK, Bae HJ, Kwon WS, Che J, Kim TS, Chung HC, Rha SY

BET inhibitor, as an epigenetic regulator inhibitor, reduces the expression of oncogenes such as Myc and Bcl-2, which affects cancer growth and development. However, it has modest activity because of...
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The nature of triple-negative breast cancer classification and antitumoral strategies

Kim S, Kim DH, Lee W, Lee YM, Choi SY, Han K

Identifying the patterns of gene expression in breast cancers is essential to understanding their pathophysiology and developing anticancer drugs. Breast cancer is a heterogeneous disease with different subtypes determined by...
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The ceRNA network of lncRNA and miRNA in lung cancer

Seo D, Kim D, Chae Y, Kim W

Since lung cancer is a major causative for cancer-related deaths, the investigations for discovering biomarkers to diagnose at an early stage and to apply therapeutic strategies have been continuously conducted....
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Comparative analysis of commonly used peak calling programs for ChIP-Seq analysis

Jeon H, Lee H, Kang B, Jang I, Roh TY

Chromatin immunoprecipitation coupled with high-throughput DNA sequencing (ChIP-Seq) is a powerful technology to profile the location of proteins of interest on a whole-genome scale. To identify the enrichment location of...
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Development of reverse transcription loop-mediated isothermal amplification assays for point-of-care testing of avian influenza virus subtype H5 and H9

Zhang S, Shin J, Shin S, Chung YJ

Avian influenza (AIV) outbreaks can induce fatal human pulmonary infections in addition to economic losses to the poultry industry. In this study, we aimed to develop a rapid and sensitive...
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BaSDAS: a web-based pooled CRISPR-Cas9 knockout screening data analysis system

Park YK, Yoon BH, Park SJ, Kim BK, Kim SY

We developed the BaSDAS (Barcode-Seq Data Analysis System), a GUI-based pooled knockout screening data analysis system, to facilitate the analysis of pooled knockout screen data easily and effectively by researchers...
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Prediction of hub genes of Alzheimer’s disease using a protein interaction network and functional enrichment analysis

Wee JJ, Kumar S

Alzheimer disease (AD) is a chronic, progressive brain disorder that slowly destroys affected individuals’ memory and reasoning faculties, and consequently, their ability to perform the simplest tasks. This study investigated...
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Druggability for COVID-19: in silico discovery of potential drug compounds against nucleocapsid (N) protein of SARS-CoV-2

Ray M, Sarkar S, Rath SN

The coronavirus disease 2019 is a contagious disease and had caused havoc throughout the world by creating widespread mortality and morbidity. The unavailability of vaccines and proper antiviral drugs encourages...
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Investigation of gene-gene interactions of clock genes for chronotype in a healthy Korean population

Park M, Kim SA, Shin J, Joo EJ

Chronotype is an important moderator of psychiatric illnesses, which seems to be controlled in some part by genetic factors. Clock genes are the most relevant genes for chronotype. In addition...
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An information-theoretical analysis of gene nucleotide sequence structuredness for a selection of aging and cancer-related genes

Blokh D, Gitarts J, Stambler I

We provide an algorithm for the construction and analysis of autocorrelation (information) functions of gene nucleotide sequences. As a measure of correlation between discrete random variables, we use normalized mutual...
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Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19

Biswas SK, Mudi SR

The severity of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), greatly varies from patient to patient. In the present study, we explored and...
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