- Prolonged hypotensive effect of human tissue kallikrein gene delivery and recombinant enzyme administration in spontaneous hypertension rats
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Sun H, Zhang L, Wang A, Xue Z
- KMID: 755661
- Exp Mol Med.
- 2004 Feb;36(1):23-27.
To evaluate the feasibility of treating hypertension by human tissue kallikrein gene (KLK1) delivery and by enzyme (rK1) administration, two recombinant vectors expressing KLK1 cDNA were constructed for gene delivery... -
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- Delivery of Factor VIII Gene into Skeletal Muscle Cells Using Lentiviral Vector
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Jeon HJ, Oh TK, Kim OH, Kim ST
- KMID: 1779606
- Yonsei Med J.
- 2010 Jan;51(1):52-57.
- doi: 10.3349/ymj.2010.51.1.52
PURPOSE: This study was designed to investigate whether transduction of lentiviral vectors (LV) carrying human coagulation factor VIII (hFVIII) cDNA into skeletal muscle could increase circulating hFVIII concentrations. MATERIALS AND... -
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- Transduction of yeast cytosine deaminase mediated by HIV-1 Tat basic domain into tumor cells induces chemosensitivity to 5-fluorocytosine
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Lee H, Ryu J, Kim KA, Lee KS, Lee JY, Park JB, Park J, Choi SY
- KMID: 755664
- Exp Mol Med.
- 2004 Feb;36(1):43-51.
Enzyme/prodrug approach is one of the actively developing areas for cancer therapy. In an effort to develop more effective enzyme/prodrug systems, cell-permeable cytosine deaminase was produced by fusing yeast cytosine... -
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- Orphan nuclear receptor small heterodimer partner inhibits angiotensin II-stimulated PAI-1 expression in vascular smooth muscle cells
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Lee KM, Seo HY, Kim MK, Min AK, Ryu SY, Kim YN, Park YJ, Choi HS, Lee KU, Park WJ, Park KG, Lee IK
- KMID: 946666
- Exp Mol Med.
- 2010 Jan;42(1):21-29.
- doi: 10.3858/emm.2010.42.1.002
Angiotensin II is a major effector molecule in the development of cardiovascular disease. In vascular smooth muscle cells (VSMCs), angiotensin II promotes cellular proliferation and extracellular matrix accumulation through the... -
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- Targeting efficiency of a-1,3-galactosyl transferase gene in pig fetal fibroblast cells
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Jin DI, Lee SH, Choi JH, Lee JS, Lee JE, Park KW, Seo JS
- KMID: 1119341
- Exp Mol Med.
- 2003 Dec;35(6):572-577.
Animal cloning technology with somatic cells provides an alternative tool to conventional methods for producing transgenic animals. Gene targeting in animals is made feasible using somatic cells with homologous recombination... -
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- Efficient amplification of melanoma-specific CD8+ T cells using artificial antigen presenting complex
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Chang J
- KMID: 1115936
- Exp Mol Med.
- 2006 Dec;38(6):591-598.
In vitro large amplification of tumor-specific cytotoxic T lymphocytes (CTLs) and adoptive transfer of these cells is one of the most promising approaches to treat malignant diseases in which an... -
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- Transgenic expression of Korean type hepatitis C virus core protein and related mutants in mice
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Wang AG, Moon HB, Lee YH, Yu SL, Kwon HJ, Han YH, Fang W, Lee TH, Jang KL, Kim SK, Yu DY, Lee DS
- KMID: 1103328
- Exp Mol Med.
- 2004 Dec;36(6):588-592.
Hepatitis C virus (HCV) is a major causative agent in liver disease. In order to investigate if Korean type HCV core protein and its related mutants, S99Q and S116I, are... -
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- Use of hydrophilic extra-viral domain of canine distemper virus H protein for enzyme-linked immunosorbent assay development
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Cho KH, Kim J, Yoo HA, Kim DH, Park SY, Song CS, Choi IS, Lee JB
- KMID: 2070236
- J Vet Sci.
- 2014 Dec;15(4):503-509.
- doi: 10.4142/jvs.2014.15.4.503
Simple methods for measuring the levels of serum antibody against canine distemper virus (CDV) would assist in the effective vaccination of dogs. To develop an enzyme-linked immunosorbent assay (ELISA) specific... -
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