- Sample Size and Power Estimation in Case-Control Genetic Association Studies
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Ahn C
- KMID: 2166209
- Genomics Inform.
- 2006 Jun;4(2):51-56.
In planning a genetic association study, it is necessary to determine the number of samples to be collected for the study in order to achieve sufficient power to detect the... -
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- Meta-Analysis of Genetic Association Studies
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Lee YH
- KMID: 2363199
- Ann Lab Med.
- 2015 May;35(3):283-287.
- doi: 10.3343/alm.2015.35.3.283
The object of this review is to help readers to understand meta-analysis of genetic association study. Genetic association studies are a powerful approach to identify susceptibility genes for common diseases.... -
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- Genetic association study of single nucleotide polymorphism in dentistry
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Kim JH, Lee JH
- KMID: 2195529
- J Korean Acad Prosthodont.
- 2011 Oct;49(4):341-345.
- doi: 10.4047/jkap.2011.49.4.341
Genetic association study has been progressed in medicine along with advance in genetic technology. It focused on the individual differences in genotype due to errors occurring during DNA duplication, which... -
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- Genetics of Ossification of the Posterior Longitudinal Ligament of the Spine: A Mini Review
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Ikegawa S
- KMID: 2241533
- J Bone Metab.
- 2014 May;21(2):127-132.
- doi: 10.11005/jbm.2014.21.2.127
Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common disease in aging populations and sometimes results in serious neurological problems due to compression of the spinal... -
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- Genetic susceptibility factors of rheumatoid arthritis
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Lee HS
- KMID: 2256060
- Korean J Med.
- 2008 Nov;75(5):515-524.
Rheumatoid arthritis (RA) is a chronic autoimmune disease that mainly involves the joints. Although the full etiology remains unclear, both genetic and environmental factors contribute to disease. Recently, genetic studies... -
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- Genetic Role in Allergic Rhinitis
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Lee JH, Koh SH
- KMID: 2297616
- J Rhinol.
- 2010 May;17(1):7-12.
Allergic rhinitis is an inflammatory disease of the nasal mucosa, induced by an IgE-mediated reaction following exposure to an allergen. Allergic rhinitis is a global health problem, with a prevalence... -
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- The Search for Genetic Variants and Epigenetics Related to Asthma
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Lee SH, Park JS, Park CS
- KMID: 2167074
- Allergy Asthma Immunol Res.
- 2011 Oct;3(4):236-244.
- doi: 10.4168/aair.2011.3.4.236
For the past two decades, a huge number of genetic studies have been conducted to identify the genetic variants responsible for asthma risk. Several types of genetic and genomic approaches,... -
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- Multiple Group Testing Procedures for Analysis of High-Dimensional Genomic Data
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Ko H, Kim K, Sun H
- KMID: 2366435
- Genomics Inform.
- 2016 Dec;14(4):187-195.
- doi: 10.5808/GI.2016.14.4.187
In genetic association studies with high-dimensional genomic data, multiple group testing procedures are often required in order to identify disease/trait-related genes or genetic regions, where multiple genetic sites or variants... -
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- Sample Size and Statistical Power Calculation in Genetic Association Studies
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Hong EP, Park JW
- KMID: 2166494
- Genomics Inform.
- 2012 Jun;10(2):117-122.
- doi: 10.5808/GI.2012.10.2.117
A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases. Genome-wide association studies require much larger... -
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- Asthma and epigenetics
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Bae DJ, Park CS
- KMID: 2263053
- Allergy Asthma Respir Dis.
- 2013 Mar;1(1):4-10.
- doi: 10.4168/aard.2013.1.1.4
For the past two decades, a huge number of genetic studies have been conducted to identify the genetic variants responsible for asthma risk. Several types of genetic and genomic approaches,... -
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- Genetics in Diabetes Mellitus - Contribution to the Classification and Management
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Yu J
- KMID: 1429704
- Ann Pediatr Endocrinol Metab.
- 2012 Dec;17(4):211-218.
- doi: 10.6065/apem.2012.17.4.211
Diabetes mellitus (DM) can be classified as type 1, type 2, and other specific types according to the underlying causes. Other specific types include genetic defects of beta-cell function, insulin... -
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- DNA Pooling as a Tool for Case-Control Association Studies of Complex Traits
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Ahn C, King TM, Lee K, Kang SH
- KMID: 1572612
- Genomics Inform.
- 2005 Mar;3(1):1-7.
Case-control studies are widely used for disease gene mapping using individual genotyping data. However, analyses of large samples are often impractical due to the expense of individual genotyping. The use... -
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- Recent progress in genetic and epigenetic research on type 2 diabetes
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Kwak SH, Park KS
- KMID: 2361507
- Exp Mol Med.
- 2016 Mar;48(3):e220.
- doi: 10.1038/emm.2016.7
Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. During the past decade, progress in genetic association studies has enabled the identification of... -
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- Integration of a Large-Scale Genetic Analysis Workbench Increases the Accessibility of a High-Performance Pathway-Based Analysis Method
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Lee S, Park T
- KMID: 2439229
- Genomics Inform.
- 2018 Dec;16(4):e39.
- doi: 10.5808/GI.2018.16.4.e39
The rapid increase in genetic dataset volume has demanded extensive adoption of biological knowledge to reduce the computational complexity, and the biological pathway is one well-known source of such knowledge.... -
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- Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes
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Park JS, Son JH, Park CS, Chang HS
- KMID: 2428272
- Yonsei Med J.
- 2019 Jan;60(1):1-9.
- doi: 10.3349/ymj.2019.60.1.1
For the past three decades, a large number of genetic studies have been performed to examine genetic variants associated with asthma and its subtypes in hopes of gaining better understanding... -
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- Genetics of Gestational Diabetes Mellitus
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Kwak SH, Jang HC, Park KS
- KMID: 2188029
- J Korean Med Assoc.
- 2009 Jul;52(7):688-694.
- doi: 10.5124/jkma.2009.52.7.688
Gestational diabetes mellitus (GDM) is defined as abnormal glucose tolerance diagnosed for the first time during pregnancy. The pathogenesis of GDM is characterized by relatively reduced insulin secretion insufficient to... -
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- Pharmacogenetic Aspects of Antipsychotic Drug-induced Weight Gain: A Critical Review
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Reynolds G
- KMID: 2171212
- Clin Psychopharmacol Neurosci.
- 2012 Aug;10(2):71-77.
Treatment with several antipsychotic drugs can result in weight gain, which may lead to further morbidity such as type 2 diabetes and cardiovascular disease via the development of metabolic syndrome.... -
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- Epilepsy syndromes during the first year of life and the usefulness of an epilepsy gene panel
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Lee EH
- KMID: 2409829
- Korean J Pediatr.
- 2018 Apr;61(4):101-107.
- doi: 10.3345/kjp.2018.61.4.101
Recent advances in genetics have determined that a number of epilepsy syndromes that occur in the first year of life are associated with genetic etiologies. These syndromes range from benign... -
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- An Association Study of the Signal Transducer and Activator of Transcription 6 Gene With Periodic Psychosis
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Kawashige , Kanazawa T, Tsutsumi A, Kikuyama H, Uenishi H, Koh J, Yoneda H
- KMID: 2315784
- Psychiatry Investig.
- 2008 Mar;5(1):41-44.
OBJECTIVE: Recent molecular and genetic investigations have suggested that the current nosology for major psychiatric disorders, based on the "two-entities-principal" is not accurate with respect to clinical observations; patient groups... -
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- Molecular genetic decoding of malformations of cortical development
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Lim JS, Lee JH
- KMID: 2055584
- J Genet Med.
- 2015 Jun;12(1):12-18.
- doi: 10.5734/JGM.2015.12.1.12
Malformations of cortical development (MCD) cover a broad spectrum of developmental disorders which cause the various clinical manifestations including epilepsy, developmental delay, and intellectual disability. MCD have been clinically classified... -
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