- RNA Interference in Functional Genomics and Medicine
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Kim VN
- KMID: 2157643
- J Korean Med Sci.
- 2003 Jun;18(3):309-318.
- doi: 10.3346/jkms.2003.18.3.309
RNA interference (RNAi) is the sequence-specific gene silencing induced by double-stranded RNA (dsRNA). Being a highly specific and efficient knockdown technique, RNAi not only provides a powerful tool for functional... -
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- Combination treatment for osteosarcoma with baculoviral vector mediated gene therapy (p53) and chemotherapy (adriamycin)
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Song SU, Boyce FM
- KMID: 755117
- Exp Mol Med.
- 2001 Mar;33(1):46-53.
The insect baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) has been evaluated as a vector for gene delivery to human tumor cells. A human osteogenic sarcoma cell line, Saos-2,... -
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- Gene and Cell Replacement via Neural Stem Cells
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Kim HT, Kim IS, Lim SE, Lee IS, Park KI
- KMID: 1726143
- Yonsei Med J.
- 2004 Jun;45(Suppl):S32-S40.
- doi: 10.3349/ymj.2004.45.Suppl.32
Neural stem cells (NSCs) are operationally defined by their ability to self-renew, to differentiate into cells of all glial and neuronal lineages throughout the neuraxis, and to populate developing or... -
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- Increased Anti-tumor Effect by a Combination of HSV Thymidine Kinase Suicide Gene Therapy and Interferon-gamma/GM-CSF Cytokine Gene Therapy in CT26 Tumor Model
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Yang SH, Oh TK, Kim ST
- KMID: 2157739
- J Korean Med Sci.
- 2005 Dec;20(6):932-937.
- doi: 10.3346/jkms.2005.20.6.932
The potential therapeutic benefit of introducing IFN-gamma and GM-CSF genes in combination with the HSVtk suicide gene into subcutaneously implanted CT26 tumor cells was compared with that from each treatment... -
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- Development of ligand-dependent regulatory system and its application to gene therapy of insulin-dependent diabetes mellitus
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Kim JM, Kim SJ, Lee HC, Kim KS
- KMID: 1110122
- Exp Mol Med.
- 2006 Aug;38(4):385-392.
To develop an inducible expression system, the enhanced artificial nuclear receptors and target reporters were constructed. Artificial nuclear receptors were generated by fusing three domains, consisting of DNA-binding domain (DBD)... -
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- Protective Effect of Recombinant Adeno-Associated Virus 2/8-Mediated Gene Therapy from the Maternal Hyperphenylalaninemia in Offsprings of a Mouse Model of Phenylketonuria
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Jung SC, Park JW, Oh HJ, Choi JO, Seo KI, Park ES, Park HY
- KMID: 1783076
- J Korean Med Sci.
- 2008 Oct;23(5):877-883.
- doi: 10.3346/jkms.2008.23.5.877
Phenylketonuria (PKU) is an autosomal recessively inherited metabolic disorder caused by a deficiency of phenylalanine hydroxylase (PAH). The accumulation of phenylalanine leads to severe mental and psychomotor retardation, and the... -
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- Bystander-Mediated Regression of Murine Neuroblastoma via Retroviral Transfer of the HSV-TK Gene
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Cho HS, Lee HR, Kim MK
- KMID: 1785703
- J Korean Med Sci.
- 2004 Feb;19(1):107-112.
- doi: 10.3346/jkms.2004.19.1.107
Selective introduction of genes conferring chemosensitivity into proliferating tumor cells may be used to treat cancer. We investigated the bystander effect of retrovirusmediated gene transfer of herpes simplex virus thymidine... -
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- In vivo Recombinant Adenovirus-mediated p53 Gene Therapy in a Syngeneic Rat Model for Colorectal Cancer
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Baek JH, Agarwal ML, Tubbs RR, Vladisavljevic A, Tomita H, Bukowski R, Milsom JW, Kim JM, Kwak JY
- KMID: 1778565
- J Korean Med Sci.
- 2004 Dec;19(6):834-841.
- doi: 10.3346/jkms.2004.19.6.834
The p53 gene has a significant role in controlling genomic stability of cancer. The purpose of this study was to evaluate the tumor response of allograft colorectal tumor treated with... -
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- Antitumor Activity of TRAIL Recombinant Adenovirus in Human Malignant Glioma Cells
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Kim KU, Seo SY, Heo KY, Yoo YH, Kim HJ, Lee HS, Choi SS, Hwang TH, Lee HJ
- KMID: 2157760
- J Korean Med Sci.
- 2005 Dec;20(6):1046-1052.
- doi: 10.3346/jkms.2005.20.6.1046
Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL) has been reported to specifically kill malignant cells but to be relatively nontoxic to normal cells. One of disadvantages to previous in vivo protocols... -
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- Optimal salt concentration of vehicle for plasmid DNA enhances gene transfer mediated by electroporation
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Lee MJ, Cho SS, Jang HS, Lim YS, You JR, Park JW, Suh HR, Kim JA, Park JS, Kim DK
- KMID: 931876
- Exp Mol Med.
- 2002 Sep;34(4):265-272.
In vivo electroporation has emerged as a leading technology for developing nonviral gene therapies, and the various technical parameters governing electroporation efficiency have been optimized by both theoretical and... -
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- Aerosol delivery of kinase-deficient Akt1 attenuates Clara cell injury induced by naphthalene in the lungs of dual luciferase mice
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Minai-Tehrani A, Park YC, Hwang SK, Kwon JT, Chang SH, Park SJ, Yu KN, Kim JE, Shin JY, Kim JH, Kang B, Hong SH, Cho MH
- KMID: 1365013
- J Vet Sci.
- 2011 Dec;12(4):309-317.
- doi: 10.4142/jvs.2011.12.4.309
Conventional lung cancer therapies are associated with poor survival rates; therefore, new approaches such as gene therapy are required for treating cancer. Gene therapies for treating lung cancer patients can... -
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