- Isolation of Mouse Ig Heavy and Light Chain Genomic DNA Clones, and Construction of Gene Knockout Vector for the Generation of Humanized Xenomouse
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Lee HK, Cha SH
- KMID: 1974523
- Immune Netw.
- 2002 Dec;2(4):233-241.
- doi: 10.4110/in.2002.2.4.233
BACKGROUND: Monoclonal antibodies (mAb) of rodent origin are produced with ease by hybridoma fusion technique, and have been successfully used as therapeutic reagents for humans after humanization by genetic engineering.... -
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- AcuD Gene Knockout Attenuates the Virulence of Talaromyces marneffei in a Zebrafish Model
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Feng J, Chen Z, He L, Xiao X, Chen C, Chu J, Mylonakis , Xi L
- KMID: 2455701
- Mycobiology.
- 2019 Jun;47(2):207-216.
- doi: 10.1080/12298093.2019.1620975
Talaromyces marneffei is the only dimorphic species in its genus and causes a fatal systemic mycosis named talaromycosis. Our previous study indicated that knockdown of AcuD gene (encodes isocitrate lyase... -
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- Production of α1,3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technology
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Kang JT, Kwon DK, Park AR, Lee EJ, Yun YJ, Ji DY, Lee K, Park KW
- KMID: 2363339
- J Vet Sci.
- 2016 Mar;17(1):89-96.
- doi: 10.4142/jvs.2016.17.1.89
Recent developments in genome editing technology using meganucleases demonstrate an efficient method of producing gene edited pigs. In this study, we examined the effectiveness of the transcription activator-like effector nuclease... -
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- Repression of HspA2 mRNA Expression in Human Testes with Abnormal Spermatogenesis
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Son WY, Hwang SH, Han CT, Lee JH, Kim SJ, Kim YC
- KMID: 2085123
- Korean J Fertil Steril.
- 1999 Apr;26(1):103-109.
OBJECTIVE: Heat shock protein 70-2 (Hsp70-2) gene knockout mice are found to have premeiotic arrest at the primary spermatocyte stage with a complete absence of spermatids and spermatozoa. This observation... -
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- BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity
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Kim DH, Do MS
- KMID: 2155394
- Exp Mol Med.
- 2015 Jan;47(1):e129.
- doi: 10.1038/emm.2014.98
Obesity is recognized as a chronic low-grade inflammatory state due to adipose tissue expansion being accompanied by an increase in the production of proinflammatory adipokines. Our group is the first... -
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- Measles Viral Infection in PD-1 Gene Knockout Mice
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Chun JK, Kim KY, Hur JA, Kang DW, Kim KH, Kim DS
- KMID: 2279038
- Korean J Pediatr Infect Dis.
- 2013 Dec;20(3):123-130.
PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a neurodegerative disease due to persistent measles virus infection. We investigated the role of programmed death-1 (PD-1) molecule which is related with chronic viral... -
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- Simultaneous deletion of floxed genes mediated by CaMKIIalpha-Cre in the brain and in male germ cells: application to conditional and conventional disruption of Goalpha
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Choi CI, Yoon SP, Choi JM, Kim SS, Lee YD, Birnbaumer L, Suh-Kim H
- KMID: 2155358
- Exp Mol Med.
- 2014 May;46(5):e93.
- doi: 10.1038/emm.2014.14
The Cre/LoxP system is a well-established approach to spatially and temporally control genetic inactivation. The calcium/calmodulin-dependent protein kinase II alpha subunit (CaMKIIalpha) promoter limits expression to specific regions of the... -
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- Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and alpha-synuclein aggregation
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Bae EJ, Yang NY, Lee C, Lee HJ, Kim S, Sardi SP, Lee SJ
- KMID: 2155418
- Exp Mol Med.
- 2015 Mar;47(3):e153.
- doi: 10.1038/emm.2014.128
Lysosomal dysfunction is a common pathological feature of neurodegenerative diseases. GTP-binding protein type A1 (GBA1) encodes beta-glucocerebrosidase 1 (GCase 1), a lysosomal hydrolase. Homozygous mutations in GBA1 cause Gaucher disease,... -
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