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Spatial and Temporal Expression, and Statin Responsiveness of Galectin-1 and Galectin-3 in Murine Atherosclerosis

Lee YJ, Koh YS, Park HE, Lee HJ, Hwang BH, Kang MK, Lee SY, Kim PJ, Ihm SH, Seung KB, Chang K

BACKGROUND AND OBJECTIVES: Existing data on the spatiotemporal expression patterns of a variety of galectins in murine atherosclerosis are limited. We investigated the expression levels of galectins, and their in...
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Galectins: Double Edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia

Than NG, Romero R, Balogh A, Karpati E, Mastrolia , Staretz-Chacham O, Hahn S, Erez O, Papp Z, Kim CJ

Galectins are an evolutionarily ancient and widely expressed family of lectins that have unique glycan-binding characteristics. They are pleiotropic regulators of key biological processes, such as cell growth, proliferation, differentiation,...
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Clinical Implication of Galectin-1 Expression in Human Breast Cancer

Moon HG, Park JI, Lee JS, Jeong CY, Joo YT, Jung EJ, Lee YJ, Hong SC, Choi SK, Ha WS, Park ST

PURPOSE: The role of different galectins in the pathogenesis of different types of malignancy is now being intensely investigated. In this study, authors investigated the level of galectin-1 expression in...
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Galectin-1, -3, -7 Expressions in Congenital and Acquired Pediatric Cholesteatomas Compared to External Auditory Canal Skin

Vander Ghinst M, Remmelink , Mansbach A, Hassid S, Choufani G

OBJECTIVES: There is a classical distinction based on clinical criteria between acquired and congenital cholesteatomas. To determine if these two types of lesions show different immunohistochemical features, we have studied...
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The Basic Studies on the Application of Galectin - 3 as a Target Protein for Delivering Anticancer Agents

Woo HJ, Joo HG

  • KMID: 1547844
  • Korean J Immunol.
  • 1997 Mar;19(1):83-90.
Gastric cancer cells express large amounts of galectin-3 on the cell surface. This fact may provide the possibility to use galectin-3 protein as a surface target for delivering cytotoxic anticancer...
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Galectin-4 Interaction with CD14 Triggers the Differentiation of Monocytes into Macrophage-like Cells via the MAPK Signaling Pathway

Hong SH, Shin JS, Chung H, Park CG

Galectin-4 (Gal-4) is a β-galactoside-binding protein mostly expressed in the gastrointestinal tract of animals. Although intensive functional studies have been done for other galectin isoforms, the immunoregulatory function of Gal-4...
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The Galectin 3 Expression in Benign and Malignant Breast Tumor

Park SY, Kim DC, Cho SH

  • KMID: 2096472
  • J Korean Surg Soc.
  • 2007 Dec;73(6):459-464.
PURPOSE: Galectin 3 is a beta-galactoside binding protein that is involved in various biological processes such as cell adhesion, migration, cell growth, tumor progression and metastasis. Although the precise acting...
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The Expression of Galectin-1 in Melanocytic Nevus, Dysplastic Nevus and Malignant Melanoma

Kim SM, Yoon TJ

  • KMID: 2247760
  • Korean J Dermatol.
  • 2009 Sep;47(9):989-996.
BACKGROUND: Galectin-1 (Gal-1) is a member of the galectin family of proteins, which are carbohydrate-binding proteins with an affinity for beta-galactosides. Gal-1 is differentially expressed by various normal and pathological...
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Galectin-9 is Involved in Immunosuppression Mediated by Human Bone Marrow-derived Clonal Mesenchymal Stem Cells

Kim SN, Lee HJ, Jeon MS, Yi T, Song SU

Bone marrow-derived mesenchymal stem cells (MSCs) have immunomodulatory properties and can suppress exaggerated pro-inflammatory immune responses. Although the exact mechanisms remain unclear, a variety of soluble factors are known to...
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Characteristic Changes in Decidual Gene Expression Signature in Spontaneous Term Parturition

El-Azzamy , Balogh A, Romero R, Xu Y, LaJeunesse C, Plazyo O, Xu Z, Price TG, Dong Z, Tarca AL, Papp Z, Hassan SS, Chaiworapongsa T, Kim CJ, Gomez-Lopez N, Than NG

BACKGROUND: The decidua has been implicated in the “terminal pathway” of human term parturition, which is characterized by the activation of pro-inflammatory pathways in gestational tissues. However, the transcriptomic changes...
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