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Is the expression of p16INK4A and galectin-3 correlated with disease progression of cervical neoplasia?

Kim SS, Cho HY, Kang SW, Kim HB, Park SH

OBJECTIVE: The aim of this study is to investigate whether the expressions of p16INK4A and galectin-3 are associated with the progression of cervical neoplasia and to evaluate its usefulness as...
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The Expression of Galectin-3, a Beta-Galactoside Binding Protein, in Dendritic Cells

Kim MH, Joo HG

BACKGROUND: Dendritic cells (DCs) are the most potent APCs (antigen-presenting cells) and play a critical role in immune responses. Galectin-3 is a biological lectin with a beta-galactoside binding affinity. Recently,...
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Expressions of Galectin-3 and HBME-1 in Nodular Lesions of the Thyroid

Choi JW, Kim BG, Cha SJ, Lee TJ, Park SJ, Park SI

  • KMID: 2096366
  • J Korean Surg Soc.
  • 2006 Sep;71(3):183-188.
PURPOSE: Galectin-3 and HBME-1 have been recognized as useful markers for the diagnosis of the thyroid lesions. In this study, we investigated whether they have a diagnostic value for nodular...
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Significance of Galectin-3 Expression in Pulmonary Non-Small Cell Carcinoma

Shin DH, Lee CH, Kang HJ, Sol MY, Lee MK

  • KMID: 1640302
  • Korean J Pathol.
  • 2006 Oct;40(5):326-332.
BACKGROUND: Non-small cell carcinoma (NSCC) has become the leading cause of cancer related death around the world. However, its prognostic factors remain poorly defined. Galectin-3 is an apoptosis related protein...
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Spatial and Temporal Expression, and Statin Responsiveness of Galectin-1 and Galectin-3 in Murine Atherosclerosis

Lee YJ, Koh YS, Park HE, Lee HJ, Hwang BH, Kang MK, Lee SY, Kim PJ, Ihm SH, Seung KB, Chang K

BACKGROUND AND OBJECTIVES: Existing data on the spatiotemporal expression patterns of a variety of galectins in murine atherosclerosis are limited. We investigated the expression levels of galectins, and their in...
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Usefulness of Galectin-3, Cytokeratin 19, p53, and Ki-67 for the Differential Diagnosis of Thyroid Tumors

Park MI, Kang DY

  • KMID: 2277677
  • Korean J Pathol.
  • 2006 Apr;40(2):86-92.
BACKGROUND: The expressions of galectin-3, cytokeratin 19, p53, and Ki-67 in papillary carcinoma (PC), follicular carcinoma (FC), follicular adenoma (FA), and nodular hyperplasia (NH) are characteristic for the differential diagnosis...
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Diagnostic Feasibility of Galectin-3 for Suspicious Malignant Thyroid Nodule in Preoperative Fine-Needle Aspiration Cytology

Eom TI, Choi JW, Min SK, Lee MJ, Park CY, Park SW, Lee BW, Kim LS

  • KMID: 2096170
  • J Korean Surg Soc.
  • 2004 Jun;66(6):462-466.
PURPOSE: Fine Needle Aspiration Cytology (FNAC) is considered as the most feasible preoperative diagnostic tool for thyroid lesions. However, the false results of FNAC are not uncommon, and so we...
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Expression of Galectin-3 and Its Diagnostic Utility as Preoperative Diagnostic Marker for Thyroid Nodule

Kang JW, Kim CJ, Nam SY

  • KMID: 2276120
  • Korean J Otolaryngol-Head Neck Surg.
  • 2004 Mar;47(3):248-251.
BACKGROUND AND OBJECTIVES: Thyroid cancer is the most common endocrine malignant disease, but making a preoperative diagnosis of this disease remains a challenge. Fine-needle aspiration biopsy (FNAB) is the most...
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The Diagnostic Accuracy of Fine Needle Aspiration Cytology and the Diagnostic Usefulness of Galectin-3 Immunostaining for the Follicular Variant of Papillary Thyroid Carcinoma

Jung CK, Shin JH, Lee HS, Lee A, Jung ES, Choi YJ, Lee KY

The cytologic diagnosis of the follicular variant of papillary thyroid carcinoma (FVPTC) has become one of the common causes of false negative diagnoses when performing fine needle aspiration cytology (FNAC)...
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Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression

Wang YG, Kim SJ, Baek JH, Lee HW, Jeong SY, Chun KH

  • KMID: 1383801
  • Exp Mol Med.
  • 2012 Jun;44(6):387-393.
Although mounting evidence indicates the involvement of galectin-3 in cancer progression and metastasis, the underlying molecular mechanisms remain largely unknown. In this study, we investigated the effect and possible mechanism...
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Comparison of Sonographic and Histopathologic Findings of Papillary Thyroid Carcinoma According to Galectin-3 immuno-staining in Fine-needle Aspiration Cytology Specimens

Kim JA, Son EJ

  • KMID: 1452959
  • J Korean Soc Ultrasound Med.
  • 2013 Jun;32(2):128-131.
PURPOSE: The purpose of this study is to compare the sonographic (US) and histopathologic findings of papillary thyroid carcinoma (PTC) according to Galectin-3 (G3) immuno-staining positivity from fine needle aspiration...
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Predictive Factors of Malignancy in Thyroid Nodules Diagnosed as Follicular Neoplasm or Hürthle Cell Neoplasm on FNA

You SH, Jung CK, Chae BJ, Song BJ, Jung SS, Bae JS

PURPOSE: The rate of malignancy in the follicular neoplasm (FN) or Hürthle cell neoplasm (HCN) of the thyroid gland is estimated as approximately 20~30%. Fine-needle aspiration biopsy (FNAB) and frozen...
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N epsilon(Carboxymethyl)Lysine-Induced Mesangial Cell Activation

Lim HJ, Song JS, Ha HJ, Lee HB

  • KMID: 2254451
  • Korean J Nephrol.
  • 2002 Jan;21(1):20-28.
BACKGROUND: Advanced glycation end products (AGE) are independent risk factors in the development and progression of diabetic nephropathy. Receptor for AGE(RAGE) is considered the main receptor involved in AGE-induced cell...
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Immunohistochemical and Molecular Characteristics of Follicular Patterned Thyroid Nodules with Incomplete Nuclear Features of Papillary Thyroid Carcinoma

Min HS, Choe G, Cho NY, Kang GH, Park SH, Park SY

BACKGROUND: Follicular patterned thyroid nodules with incomplete nuclear features of papillary thyroid carcinoma (FTN-INPTCs) are difficult to diagnose, and their biological behavior and association with follicular variants of PTC (FVPTCs)...
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Overexpression of Galectin-3 in Macrophages of C57BL/6 mice with Experimental Autoimmune Encephalomyelitis

Kim DS, Hwang I, Park SJ, Ahn G, Park SJ, Park HJ, Joo HG, Jee Y

  • KMID: 1446206
  • Korean J Vet Res.
  • 2011 Jun;51(2):139-149.
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease in the murine central nervous system (CNS) and has long been used as an animal model for human multiple sclerosis. Development of...
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Follicular Variant of Papillary Thyroid Carcinoma; Clinicopathologic Features

Kim SY, Chae BJ, Jung SR, Jung CK, Lim DJ, Song BJ, Kim JS, Kim SN, Bae JS

PURPOSE: The follicular variant of papillary thyroid carcinoma (FVPTC) is the most common subtype of papillary thyroid carcinoma (PTC). However, the clinicopathologic features of patients with FVPTC with those of...
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Atractylochromene Is a Repressor of Wnt/beta-Catenin Signaling in Colon Cancer Cells

Shim AR, Dong GZ, Lee HJ, Ryu JH

Wnt/beta-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated beta-catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the...
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The utility of biomarker risk prediction score in patients with chronic heart failure

Berezin AE, Kremzer AA, Martovitskaya YV, Berezina T, Samura TA

BACKGROUND: Chronic heart failure (CHF) has been remained a leading cause of cardiovascular morbidity and mortaluty. The risk stratification of CHF individuals based on clinical criteria and biomarkers' models may...
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CD56 and High Molecular Weight Cytokeratin as Diagnostic Markers of Papillary Thyroid Carcinoma

Shin MK, Kim JW, Ju YS

BACKGROUND: The incidence of papillary thyroid carcinoma (PTC) has been increasing recently and a precise diagnosis is essential for optimal treatment. Ancillary immunohistochemical stains are important for diagnosing some difficult...
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The Cancer Genome Atlas Validation of Ancillary Tests for Classifying Papillary Thyroid Carcinoma

Suh YJ, Moon HJ, Choe JY, Park HJ

BACKGROUND AND OBJECTIVES: Ancillary tests such as BRAF(V600E) mutation or immunohistochemical (IHC) assays have been utilized as complements to morphological criteria in diagnosing subsets of papillary thyroid carcinoma (PTC). Utilizing results...
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