- RGS Proteins and Opioid Signaling
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Kim KS, Palmer PP, Kim KJ
- KMID: 2278010
- Korean J Pain.
- 2006 Jun;19(1):8-16.
- doi: 10.3344/kjp.2006.19.1.8
The regulators of the G protein signaling (RGS) proteins are responsible for the rapid acceleration of the GTPase-activity intrinsic to the heterotrimeric G protein alpha subunits. As GTPase-activating proteins (GAP),... -
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- Expression of signal transducing G proteins in human melanoma cell lines
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Lee ES, Kang WH, Jin YH, Juhnn YS
- KMID: 1532666
- Exp Mol Med.
- 1997 Dec;29(4):223-227.
Some malignant melanoma cells regress spontaneously by terminal differentiation, and understanding the mechanisms of this spontaneous regression can contribute to the development of a new therapy not only for melanoma... -
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- Mutational Analysis of Gsalpha Protein in Fibrous dysplasia of the Bone
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Rhee SY, Woo JT, Koh G, Oh S, Kim SW, Kim JW, Kim YS, Park YK
- KMID: 2331194
- J Korean Soc Endocrinol.
- 2005 Apr;20(2):142-147.
BACKGROUND: Fibrous dysplasia of the bone(FD) is a benign fibrous bone lesion which usually involves the long bones of the extremities. FD may be asymptomatic, but often leads to bone... -
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- Inhibition of gamma ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblastoma cells
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Kim SY, Seo M, Oh JM, Cho EA, Juhnn YS
- KMID: 1090961
- Exp Mol Med.
- 2007 Oct;39(5):583-593.
Heterotrimeric GTP-binding proteins (G proteins) transduce extracellular signals into intracellular signals by activating effector molecules including adenylate cyclases that catalyze cAMP formation, and thus regulate various cellular responses such as... -
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- The Influences of G Proteins, Ca2+, and K+ Channels on Electrical Field Stimulation in Cat Esophageal Smooth Muscle
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Park JH, Kim HS, Park SY, Im C, Jeong JH, Kim IK, Sohn UD
- KMID: 1982574
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):393-400.
- doi: 10.4196/kjpp.2009.13.5.393
NO released by myenteric neurons controls the off contraction induced by electrical field stimulation (EFS) in distal esophageal smooth muscle, but in the presence of nitric oxide synthase (NOS) inhibitor,... -
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- Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes
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Kimple ME, Neuman JC, Linnemann , Casey PJ
- KMID: 2155367
- Exp Mol Med.
- 2014 Jun;46(6):e102.
- doi: 10.1038/emm.2014.40
The worldwide prevalence of obesity is steadily increasing, nearly doubling between 1980 and 2008. Obesity is often associated with insulin resistance, a major risk factor for type 2 diabetes mellitus... -
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- Gonadotropin Regulation of Regulator of G Protein Signaling 2 (RGS-2) Expression in the Rat Ovary
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Lee YI, Lee ES, Kim SA, Kim MY, Cho MK, Chun SY
- KMID: 1986919
- Korean J Reprod Med.
- 2008 Jun;35(2):111-118.
OBJECTIVE: The purpose of the present study was to examine the hormonal regulation of RGS-2 in the rat ovary. METHODS: Immature rats were injected with 10 IU of PMSG to induce... -
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- An inhibitory compound against the interaction between Galpha(s) and the third intracellular loop region of serotonin receptor subtype 6 (5-HT(6)) disrupts the signaling pathway of 5-HT(6)
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Choi YH, Kang H, Lee WK, Kim T, Rhim H, Yu YG
- KMID: 1047084
- Exp Mol Med.
- 2007 Jun;39(3):335-342.
Serotonin receptor subtype 6 (5-HT(6)) is a neurotransmitter receptor, which is involved in various brain functions such as memory and mood. It mediates signaling via the interaction with a stimulatory... -
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- Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells
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Choi YJ, Kim SY, Oh JM, Juhnn YS
- KMID: 1119325
- Exp Mol Med.
- 2009 Aug;41(8):592-600.
- doi: 10.3858/emm.2009.41.8.065
Stimulatory heterotrimeric GTP-binding proteins (Gs protein) stimulate cAMP generation in response to various signals, and modulate various cellular phenomena such as proliferation and apoptosis. This study aimed to investigate the... -
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- Galpha12 Protects Vascular Endothelial Cells from Serum Withdrawal-Induced Apoptosis through Regulation of miR-155
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Lee HJ, Lee EJ, Seo M
- KMID: 2466377
- Yonsei Med J.
- 2016 Jan;57(1):247-253.
- doi: 10.3349/ymj.2016.57.1.247
PURPOSE: Apoptosis of vascular endothelial cells is a type of endothelial damage that is associated with the pathogenesis of cardiovascular diseases such as atherosclerosis. Heterotrimeric GTP-binding proteins (G proteins), including... -
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- Cooperation of Gbeta and Galphaq Protein in Contractile Response of Cat Lower Esophageal Sphincter (LES)
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Sohn UD, Lee TS
- KMID: 1607520
- Korean J Physiol Pharmacol.
- 2003 Dec;7(6):349-355.
We previously shown that LES contraction depends on M3 receptors linked to PTX insensitive Gq protein and activation of PLC. This results in production of IP3, which mediates calcium release,... -
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- Simultaneous deletion of floxed genes mediated by CaMKIIalpha-Cre in the brain and in male germ cells: application to conditional and conventional disruption of Goalpha
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Choi CI, Yoon SP, Choi JM, Kim SS, Lee YD, Birnbaumer L, Suh-Kim H
- KMID: 2155358
- Exp Mol Med.
- 2014 May;46(5):e93.
- doi: 10.1038/emm.2014.14
The Cre/LoxP system is a well-established approach to spatially and temporally control genetic inactivation. The calcium/calmodulin-dependent protein kinase II alpha subunit (CaMKIIalpha) promoter limits expression to specific regions of the... -
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- Effect of Pertussis Toxin and Herbimycin A on Proteinase-Activated Receptor 2-Mediated Cyclooxygenase 2 Expression in Helicobacter pylori-Infected Gastric Epithelial AGS Cells
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Seo JH, Seo JY, Chung HY, Kim H
- KMID: 1777026
- Yonsei Med J.
- 2011 May;52(3):522-526.
- doi: 10.3349/ymj.2011.52.3.522
Helicobacter pylori (H. pylori) is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. Proteinase-activated receptor 2 (PAR2), subgroup of G-protein coupled receptor family, is highly expressed... -
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- A Case of McCune-Albright Syndrome with Associated Multiple Endocrinopathies
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Sung SH, Yoon HD, Shon HS, Kim HT, Choi WY, Seo CJ, Lee JH
- KMID: 1717995
- Korean J Intern Med.
- 2007 Mar;22(1):45-50.
- doi: 10.3904/kjim.2007.22.1.45
McCune-Albright syndrome (MAS) is a rare disorder that develops from an activating mutation in the Gs gene. It is characterized by an association with Polyostotic fibrous dysplasia, and precocious puberty,... -
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- Gene expression profiling of light-induced retinal degeneration in phototransduction gene knockout mice
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Krishnan J, Chen J, Shin KJ, Hwang JI, Han SU, Lee G, Choi S
- KMID: 1104803
- Exp Mol Med.
- 2008 Oct;40(5):495-504.
- doi: 10.3858/emm.2008.40.5.495
Exposure to light can induce photoreceptor cell death and exacerbate retinal degeneration. In this study, mice with genetic knockout of several genes, including rhodopsin kinase (Rhok-/-), arrestin (Sag-/-), transducin (Gnat1-/-),... -
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- Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells
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Jeong KJ, Park SY, Seo JH, Lee KB, Choi WS, Han JW, Kang JK, Park CG, Kim YK, Lee HY
- KMID: 1072941
- Exp Mol Med.
- 2008 Dec;40(6):607-616.
- doi: 10.3858/emm.2008.40.6.607
Lysophosphatidic acid (LPA) is a bioactive phospholipids and involves in various cellular events, including tumor cell migration. In the present study, we investigated LPA receptor and its transactivation to EGFR... -
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