- Down-regulation of Type I Collagen Gene Expression in Human Skin Fibroblasts by G1 Cell Cycle Arrest
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Park YD, Lee KS
- KMID: 1931117
- Korean J Dermatol.
- 2007 Apr;45(4):362-368.
BACKGROUND: Type I collagen is a major component of extracellular cellular matrix in tissue. It is synthesized by human skin fibroblasts. However, synthesis of type I collagen is markedly-decreased in... -
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- Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells
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Lee HS, Kim EJ, Kim SH
- KMID: 2313817
- Nutr Res Pract.
- 2015 Apr;9(2):111-116.
- doi: 10.4162/nrp.2015.9.2.111
BACKGROUND/OBJECTIVES: Inonotus obliquus (I. obliquus, Chaga mushroom) has long been used as a folk medicine to treat cancer. In the present study, we examined whether or not ethanol extract of... -
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- THE ROLE OF REGULATED PROTEINS RELATED TO CELL CYCIE IN CARCINOGENESIS
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Kwak DH, Lee SH, Kim CH
- KMID: 2190615
- J Korean Assoc Oral Maxillofac Surg.
- 1997 Jul;23(3):374-387.
The cell cycle is composed of G1, S, G2 and M phase. The transitions between different phases are regulated at checkpoint such as Start(restriction), S phase and mitotic checkpoint. These... -
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- A Natural Product, Chios Gum Mastic, Induces the Death of HL-60 Cells via Apoptosis and Cell Cycle Arrest
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Koo BC, Kim DH, Kim IR, Kim GC, Kwak HH, Park BS
- KMID: 2135279
- Int J Oral Biol.
- 2011 Mar;36(1):13-21.
Chios gum mastic (CGM) is produced from Pistiacia lentiscus L var chia, which grows only on Chios Island in Greece. CGM is a kind of resin extracted from the stem... -
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- High-Dose 111In Induces G1 Cell Cycle Arrest and Cell Death in Rat Bone Marrow Mesenchymal Stem Cells
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Park BN, Shim W, Ahn YH, Lee JH, An YS, Yoon JK
- KMID: 2052002
- Nucl Med Mol Imaging.
- 2012 Jun;46(2):81-88.
PURPOSE: This study was performed to evaluate the effect of 111In-labeling on the cell growth, cycle and viability of bone marrow mesenchymal stem cells (BMSCs). METHODS: Rat BMSCs were labeled with... -
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- Chios Gum Mastic Induces Cell Cycle Arrest and Apoptosis in Human Osteosarcoma Cells
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Min JH, Kim DK, Kwak HH, Kim GC, Lee SE, Kim IR, Kim CH, Park BS
- KMID: 1472476
- Korean J Anat.
- 2009 Dec;42(4):245-256.
Chios gum mastic (CGM) is a resin produced from the stem and leaves of Pistiacia lentiscus L var chia, a plant which grows only on Chios Island in Greece. CGM... -
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- Cyclin D1 Overexpression, p16 Loss, and pRb Inactivation Play a Key Role in Pulmonary Carcinogenesis and have a Prognostic Implication for the Long-term Survival in Non-small Cell Lung Carcinoma Patients
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Myong NH
- KMID: 2166001
- Cancer Res Treat.
- 2008 Jun;40(2):45-52.
PURPOSE: We investigated the immunoexpressions of cyclin D1, cyclin-dependent kinase inhibitor p16 and phosphorylated retinoblastoma (p-pRb) proteins in non- small cell lung carcinoma (NSCLC) to demonstrate their key roles in... -
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- The Apoptosis and Expressions of p53, bcl-2, bax, PCNA, and cyclin D1 in Porokeratosis, Actinic Keratosis, and Squamous Cell Carcinoma
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Choi YW, Choi HY, Myung KB
- KMID: 2230304
- Korean J Dermatol.
- 2000 Nov;38(11):1453-1460.
BACKGROUND: Apoptosis is an important negative growth regulatory mechanism in tumors. In some malignancies, the apoptotic index(the percentage of apoptotic cells/bodies in the total number of tumor cells) may reflect... -
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- Effects of Peroxisome Proliferator-activated Receptor-gamma(PPARgamma) on the Pancreatic beta Cell Proliferation
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Noh JH, Yang TY, Jeong IK, Chung JH, Min YK, Lee MS, Kim KW, Lee MK
- KMID: 1768001
- J Korean Diabetes Assoc.
- 2003 Jun;27(3):241-252.
BACKGROUND: The effects and mechanisms of PPARgamma ligands on the cell proliferation in pancreatic beta cells were examined. METHODS: PPARgamma 1 cDNA was overexpressed in INS-1 cells using an... -
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- Inhibitory effects of resveratrol on hepatitis B virus X protein-induced hepatocellular carcinoma
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Park S, Lim J, Kim JR, Cho S
- KMID: 2398500
- J Vet Sci.
- 2017 Dec;18(4):419-429.
- doi: 10.4142/jvs.2017.18.4.419
Liver cancer occurs very frequently worldwide and hepatocellular carcinoma (HCC) accounts for more than 80% of total primary liver cancer cases. In this study, the anticarcinogenic effects of resveratrol against... -
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- Suppressor of Variegation 3–9 Homolog 2, a Novel Binding Protein of Translationally Controlled Tumor Protein, Regulates Cancer Cell Proliferation
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Kim AR, Sung JY, Rho SB, Kim YN, Yoon K
- KMID: 2442016
- Biomol Ther.
- 2019 Feb;27(2):231-239.
- doi: 10.4062/biomolther.2019.021
Suppressor of Variegation 3–9 Homolog 2 (SUV39H2) methylates the lysine 9 residue of histone H3 and induces heterochromatin formation, resulting in transcriptional repression or silencing of target genes. SUV39H1 and... -
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- Dehydroglyasperin D Inhibits the Proliferation of HT-29 Human Colorectal Cancer Cells Through Direct Interaction With Phosphatidylinositol 3-kinase
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Jung SK, Jeong CH
- KMID: 2161520
- J Cancer Prev.
- 2016 Mar;21(1):26-31.
- doi: 10.15430/JCP.2016.21.1.26
BACKGROUND: Despite recent advances in therapy, colorectal cancer still has a grim prognosis. Although licorice has been used in East Asian traditional medicine, the molecular properties of its constituents including... -
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- Human Papilloma Virus Type 16 E7 Oncoprotein Stabilizes p53 Protein but not Induced p53-mediated Apoptosis in HepG2 Cells after gamma-irradiation under Hypoxia
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Hwang HJ, Choi EJ, Choi YJ, Lee WT, Park KA, Lee JE
- KMID: 2092894
- Korean J Anat.
- 2007 Jun;40(2):95-106.
Human papilloma virus 16 E6 and E7 oncoproteins are well known to change cell functions, especially through p53 and pRb expression, so we studied their effects on molecular mechanisms and... -
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- Influence of P53 on the radiotherapy response of hepatocellular carcinoma
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Gomes AR, Abrantes A, Brito AF, Laranjo M, Casalta-Lopes JE, Goncalves , Sarmento-Ribeiro AB, Botelho MF, Tralhao JG
- KMID: 2351026
- Clin Mol Hepatol.
- 2015 Sep;21(3):257-267.
- doi: 10.3350/cmh.2015.21.3.257
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and it has a poor prognosis and few therapeutic options. Radiotherapy is one of the most effective forms... -
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- MS-5, a Naphthalene Derivative, Induces the Apoptosis of an Ovarian Cancer Cell CAOV-3 by Interfering with the Reactive Oxygen Species Generation
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Ma E, Jeong SJ, Choi JS, Nguyen TH, Jeong CH, Joo SH
- KMID: 2432066
- Biomol Ther.
- 2019 Jan;27(1):48-53.
- doi: 10.4062/biomolther.2018.020
Reactive oxygen species (ROS) are widely generated in biological processes such as normal metabolism and response to xenobiotic exposure. While ROS can be beneficial or harmful to cells and tissues,... -
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- The Synergistic Apoptotic Interaction of Indole-3-Carbinol and Genistein with TRAIL on Endometrial Cancer Cells
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Parajuli B, Shin SJ, Kwon SH, Cha SD, Lee HG, Bae I, Cho CH
- KMID: 1786959
- J Korean Med Sci.
- 2013 Apr;28(4):527-533.
- doi: 10.3346/jkms.2013.28.4.527
Induction of apoptosis in target cells is a key mechanism by which chemotherapy promotes cell killing. The purpose of this study was to determine whether Indole-3-Carbinol (I3C) and Genistein in... -
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- Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer
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Nam AR, Kim JW, Park JE, Bang JH, Jin MH, Oh DY, Bang YJ
- KMID: 2454281
- Cancer Res Treat.
- 2019 Jul;51(3):886-900.
- doi: 10.4143/crt.2018.375
PURPOSE: Jab1 is a coactivator of c-Jun that enhances the transcriptional function of c-Jun. Jab1 is frequently overexpressed in various cancers and is associatedwith poor prognosis of cancer patients. Thus,... -
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- Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
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Kim DS, Na YJ, Kang MH, Yoon SY, Choi CW
- KMID: 2373811
- Korean J Intern Med.
- 2016 Mar;31(2):357-366.
- doi: 10.3904/kjim.2015.024
BACKGROUND/AIMS: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed,... -
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- Cyclin D1 Expression in Primary Breast Carcinoma: Correlation with Estrogen Receptor Status and Other Clinicopathologic Parameters
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Seo HC, Kim SI, Yang WI, Park CH, Park CJ
- KMID: 2173567
- J Korean Breast Cancer Soc.
- 2002 Mar;5(1):1-6.
- doi: 10.4048/jkbcs.2002.5.1.1
PURPOSE: Cyclins are groups of proteins that play a role as a major regulator of the G1 restriction point promoting inactivation of the retinoblastoma protein. The cyclin D1 gene, CCND1,... -
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- Cyclin D1 Expression in Primary Breast Carcinoma: Correlation with Estrogen Receptor Status and Other Clinicopathologic Parameters
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Seo HC, Kim SI, Yang WI, Park CH, Park CJ
- KMID: 2324959
- J Korean Surg Soc.
- 2001 Nov;61(5):479-484.
PURPOSE: Cyclins are groups of proteins that play a role as a major regulator of the G1 restriction point promoting inactivation of the retinoblastoma protein. The cyclin D1 gene, CCND1,... -
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