- Eribulin for Advanced Breast Cancer: A Drug Evaluation
-
Shablak A
- KMID: 2374539
- J Breast Cancer.
- 2013 Mar;16(1):12-15.
Eribulin is a synthetic microtubule dynamics inhibitor that was developed from a marine natural product halichondrin B. It exhibited in vitro and in vivo activities against a wide number of... -
- CITED
-
- Close
- SHARE
-
- Close
- Differential Effects of Tautomycetin and Its Derivatives on Protein Phosphatase Inhibition, Immunosuppressive Function and Antitumor Activity
-
Niu M, Sun Y, Liu B, Tang L, Qiu R
- KMID: 2071761
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):145-151.
- doi: 10.4196/kjpp.2012.16.2.145
In the present work, we studied the structure-activity relationship (SAR) of tautomycetin (TMC) and its derivatives. Further, we demonstrated the correlation between the immunosuppressive fuction, anticancer activity and protein phosphatase... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of manassantin B, a lignan isolated from Saururus chinensis, on lipopolysaccharide-induced interleukin-1beta in RAW 264.7 cells
-
Park HC, Bae HB, Jeong CW, Lee SH, Jeung HJ, Kwak SH
- KMID: 2236296
- Korean J Anesthesiol.
- 2012 Feb;62(2):161-165.
- doi: 10.4097/kjae.2012.62.2.161
BACKGROUND: Elevated systemic levels of pro-inflammatory cytokines cause hypotension during septic shock and induce capillary leakage in acute lung injury. Manassantin B has anti-inflammatory and anti-plasmoidal properties. This study examined... -
- CITED
-
- Close
- SHARE
-
- Close
- Major clinical research advances in gynecologic cancer in 2011
-
Suh DH, Kim K, Kim JW
- KMID: 2177515
- J Gynecol Oncol.
- 2012 Jan;23(1):53-64.
- doi: 10.3802/jgo.2012.23.1.53
The annual review of 2011 comprised 11 themes of major research achievements in gynecologic oncology including breast cancer. A potential paradigm shift in the management of ovarian cancer was reviewed... -
- CITED
-
- Close
- SHARE
-
- Close
- beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
-
Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I
- KMID: 2155408
- Exp Mol Med.
- 2015 Feb;47(2):e143.
- doi: 10.1038/emm.2014.127
An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene.... -
- CITED
-
- Close
- SHARE
-
- Close
- A Randomized, Multicenter, Phase III Trial to Evaluate the Efficacy and Safety of Polmacoxib Compared with Celecoxib and Placebo for Patients with Osteoarthritis
-
Lee M, Yoo J, Kim JG, Kyung HS, Bin SI, Kang SB, Choi CH, Moon YW, Kim YM, Han SB, In Y, Choi CH, Kim J, Lee BK, Cho S
- KMID: 2412245
- Clin Orthop Surg.
- 2017 Dec;9(4):439-457.
- doi: 10.4055/cios.2017.9.4.439
BACKGROUND: The aim of this study was to evaluate the safety and analgesic efficacy of polmacoxib 2 mg versus placebo in a superiority comparison or versus celecoxib 200 mg in... -
- CITED
-
- Close
- SHARE
-
- Close
- p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest
-
Chae HD, Kim SY, Park SE, Kim J, Shin DY
- KMID: 1245266
- Exp Mol Med.
- 2012 Mar;44(3):236-240.
- doi: 10.3858/emm.2012.44.3.018
We previously reported that the p53 tumor suppressor protein plays an essential role in the induction of tetraploid G1 arrest in response to perturbation of the actin cytoskeleton, termed actin... -
- CITED
-
- Close
- SHARE
-
- Close
- Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase
-
Chung BH, Kim S, Kim JD, Lee JJ, Baek YY, Jeoung D, Lee H, Choe J, Ha KS, Won MH, Kwon YG, Kim YM
- KMID: 1245262
- Exp Mol Med.
- 2012 Mar;44(3):191-201.
- doi: 10.3858/emm.2012.44.3.014
Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays an important role in vascular functions, including vasorelaxation. We here investigated the pharmacological effect of the natural product syringaresinol on... -
- CITED
-
- Close
- SHARE
-
- Close
