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We studied the regulation of fibronectin (FN) gene expression by cAMP and
phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells.
Dibutyryl cAMP increased FN synthesis and mRNA levels, while PMA inhibited...
Two intracellular signal pathways mediated by cAMP and protein kinase C (PKC)
were involved in the regulation of FN gene expression (Lee et al., Exp. Mol.
Med. 30: 240, 1998). In this...
Metformin has anti-inflammatory and anti-fibrotic effects. We investigated whether metformin has an inhibitory effect on bleomycin (BLM)-induced pulmonary fibrosis in a murine model. A total of 62 mice were divided...
PURPOSE: This study was undertaken to investigate the effects of gamma linolenic acid (GLA) on inflammation and extracellular matrix (ECM) synthesis in mesangial and tubular epithelial cells under diabetic conditions.
MATERIALS...