- Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway
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Kim HR, Park MK, Cho ML, Kim KW, Oh HJ, Park JS, Heo YM, Lee SH, Kim HY, Park SH
- KMID: 1776614
- Korean J Intern Med.
- 2010 Sep;25(3):317-326.
- doi: 10.3904/kjim.2010.25.3.317
BACKGROUND/AIMS: This study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. METHODS: Human RA... -
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- Free radical scavenging and antioxidant enzyme fortifying activities of extracts from Smilax china root
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Lee SE, Ju EM, Kim JH
- KMID: 1457540
- Exp Mol Med.
- 2001 Dec;33(4):263-268.
The extract from Smilax china root has been used as medicinal remedy and reported to retain antimicrobial and antimutagenic acitivities. In this study, a possible presence of antioxidant activity of... -
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- Effects of Hepatocyte Growth Factor on Collagen Synthesis and Matrix Metalloproteinase Production in Keloids
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Lee WJ, Park SE, Rah DK
- KMID: 1777848
- J Korean Med Sci.
- 2011 Aug;26(8):1081-1086.
- doi: 10.3346/jkms.2011.26.8.1081
Keloids are pathologic proliferations of the dermal layer of the skin resulting from excessive collagen production and deposition. Hepatocyte growth factor (HGF) increases the expression of matrix metalloproteinase (MMP)-1 and... -
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- Adipogenic and Lipolytic Effects of Ascorbic Acid in Ovariectomized Rats
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Kim B, Choi KM, Yim HS, Park HT, Yim JH, Lee MG
- KMID: 2418853
- Yonsei Med J.
- 2018 Jan;59(1):85-91.
- doi: 10.3349/ymj.2018.59.1.85
PURPOSE: Ascorbic acid has been reported to have an adipogenic effect on 3T3-L1 preadipocytes, while evidence also suggests that ascorbic acid reduces body weight in humans. In this study, we... -
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- Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-kappa B pathway in human dermal fibroblasts
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Lee YR, Noh EM, Jeong EY, Yun SK, Jeong YJ, Kim JH, Kwon KB, Kim BS, Lee SH, Park CS, Kim JS
- KMID: 1119320
- Exp Mol Med.
- 2009 Aug;41(8):548-554.
- doi: 10.3858/emm.2009.41.8.060
Cordycepin (3'-deoxyadenosine) has been shown to exhibit many pharmacological activities, including anti-cancer, anti-inflammatory, and anti-infection activities. However, the anti-skin photoaging effects of cordycepin have not yet been reported. In the... -
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- Slug suppression induces apoptosis via Puma transactivation in rheumatoid arthritis fibroblast-like synoviocytes treated with hydrogen peroxide
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Cha HS, Bae EK, Ahn JK, Lee J, Ahn KS, Koh EM
- KMID: 1078358
- Exp Mol Med.
- 2010 Jun;42(6):428-436.
- doi: 10.3858/emm.2010.42.6.044
Inadequate apoptosis contributes to synovial hyperplasia in rheumatoid arthritis (RA). Recent study shows that low expression of Puma might be partially responsible for the decreased apoptosis of fibroblast-like synoviocytes (FLS).... -
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