- Immortalization of human embryonic fibroblasts by overexpression of c-myc and simian virus 40 large T antigen
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Kim HS, Shin JY, Yun JY, Ahn DK, Lee JY
- KMID: 1457544
- Exp Mol Med.
- 2001 Dec;33(4):293-298.
SV40 large T antigen, a viral oncoprotein, is known to immortalize human diploid fibroblast by soaking up cellular RB and p53, but its frequency is extremely low. Additional genetic alteration... -
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- Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase
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Jung GA, Shin BS, Jang YS, Sohn JB, Woo SR, Kim JE, Choi G, Lee KM, Min BH, Lee KH, Park GH
- KMID: 1123367
- Exp Mol Med.
- 2011 Oct;43(10):550-560.
- doi: 10.3858/emm.2011.43.10.061
Protein arginine methylation is important for a variety of cellular processes including transcriptional regulation, mRNA splicing, DNA repair, nuclear/cytoplasmic shuttling and various signal transduction pathways. However, the role of arginine... -
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- Differentially Expressed Proteins in Nitric Oxide-Stimulated NIH/3T3 Fibroblasts: Implications for Inhibiting Cancer Development
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Shim DH, Lim JW, Kim H
- KMID: 2070039
- Yonsei Med J.
- 2015 Mar;56(2):563-571.
- doi: 10.3349/ymj.2015.56.2.563
PURPOSE: Recent evidence shows that nitric oxide (NO) may exhibit both pro-cancer and anti-cancer activities. The present study aimed to determine the differentially expressed proteins in NO-treated NIH/3T3 fibroblasts in... -
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- Isoprenaline Induces Periostin Expression in Gastric Cancer
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Liu GX, Xi HQ, Sun XY, Geng ZJ, Yang SW, Lu YJ, Wei B, Chen L
- KMID: 2374072
- Yonsei Med J.
- 2016 May;57(3):557-564.
- doi: 10.3349/ymj.2016.57.3.557
PURPOSE: Periostin mediates critical steps in gastric cancer and is involved in various signaling pathways. However, the roles of periostin in promoting gastric cancer metastasis are not clear. The aim... -
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- MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis
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Lee DG, Woo JW, Kwok SK, Cho ML, Park SH
- KMID: 2154239
- Exp Mol Med.
- 2013 Apr;45(4):e20.
Myeloid-related protein (MRP)8/MRP14 is an endogenous Toll-like receptor 4 (TLR4) ligand and is abundant in synovial fluid (SF) of rheumatoid arthritis (RA) patients. Belonging to damage-associated molecular patterns, it amplifies... -
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- 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells
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Lee SE, Lee EY, Kang SJ, Lee SH
- KMID: 2418903
- Yonsei Med J.
- 2017 Nov;58(6):1204-1210.
- doi: 10.3349/ymj.2017.58.6.1204
PURPOSE: Glucocorticoids, stress-related hormones, inhibit hair growth. Intracellular glucocorticoid availability is regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 11β-HSD1 was recently detected in keratinocytes and fibroblasts. However, the expression of... -
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- Expression of CCR2A, an isoform of MCP-1 receptor, is increased by MCP-1, CD40 ligand and TGF-beta in fibroblast like synoviocytes of patients with RA
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Cho ML, Yoon BY, Ju JH, Jung YO, Jhun JY, Park MK, Park SH, Cho CS, Kim HY
- KMID: 756073
- Exp Mol Med.
- 2007 Aug;39(4):499-507.
Cytokine and chemokine receptors play a key role in inflammation caused by rheumatoid arthritis (RA). Two isoforms of human CC chemokine receptor R2 (CCR2), the receptor of monocyte chemoattractant protein... -
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