- Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes
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Kim H, Kim M, Im SK, Fang S
- KMID: 2459290
- Lab Anim Res.
- 2018 Dec;34(4):147-159.
- doi: 10.5625/lar.2018.34.4.147
Genetically engineered mouse models are commonly preferred for studying the human disease due to genetic and pathophysiological similarities between mice and humans. In particular, Cre-loxP system is widely used as... -
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- Bile Acid Receptor Farnesoid X Receptor: A Novel Therapeutic Target for Metabolic Diseases
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Fang S
- KMID: 2385838
- J Lipid Atheroscler.
- 2017 Jun;6(1):1-7.
- doi: 10.12997/jla.2017.6.1.1
Bile acid has been well known to serve as a hormone in regulating transcriptional activity of Farnesoid X receptor (FXR), an endogenous bile acid nuclear receptor. Moreover, bile acid regulates... -
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- Crosstalk between FXR and TGR5 controls glucagon-like peptide 1 secretion to maintain glycemic homeostasis
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Kim H, Fang S
- KMID: 2459289
- Lab Anim Res.
- 2018 Dec;34(4):140-146.
- doi: 10.5625/lar.2018.34.4.140
Though bile acids have been well known as digestive juice, recent studies have demonstrated that bile acids bind to their endogenous receptors, including Farnesoid X receptor (FXR) and G protein-coupled... -
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- Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease
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Kim SG, Kim BK, Kim K, Fang S
- KMID: 2373067
- Endocrinol Metab.
- 2016 Dec;31(4):500-504.
- doi: 10.3803/EnM.2016.31.4.500
Nonalcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver, occurring when fat is accumulated in the liver without alcohol consumption. NAFLD is the most common liver... -
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- DGAT2 Plays a Crucial Role to Control ESRRAPROX1 Transcriptional Network to Maintain Hepatic Mitochondrial Sustainability
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Lee Y, Hwang Y, Kim M, Jeon H, Joo S, Fang S, Kim JW
- KMID: 2559000
- Diabetes Metab J.
- 2024 Sep;48(5):901-914.
- doi: 10.4093/dmj.2023.0368
Background: Diacylglycerol O-acyltransferase 2 (DGAT2) synthesizes triacylglycerol (TG) from diacylglycerol; therefore, DGAT2 is considered as a therapeutic target for steatosis. However, the consequence of inhibiting DGAT2 is not fully investigated... -
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- Development and Validation of a Pathomics Model Using Machine Learning to Predict CXCL8 Expression and Prognosis in Head and Neck Cancer
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Wang W, Ruan S, Xie Y, Fang S, Yang J, Li X, Zhang Y
- KMID: 2553059
- Clin Exp Otorhinolaryngol.
- 2024 Feb;17(1):85-97.
- doi: 10.21053/ceo.2023.00026
Objectives. The necessity to develop a method for prognostication and to identify novel biomarkers for personalized medicine in patients with head and neck squamous cell carcinoma (HNSCC) cannot be overstated.... -
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- Evaluation of Molecular Residual Disease by a Fixed Panel in Resectable Colorectal Cancer
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Yang J, Yu C, Li H, Peng D, Zhou Q, Yao J, Lv J, Fang S, Shi J, Wei Y, Wang G, Cai S, Zhang Z, Zhang Z, Zhou J
- KMID: 2560252
- Cancer Res Treat.
- 2024 Oct;56(4):1183-1196.
- doi: 10.4143/crt.2023.1371
Purpose Molecular residual disease (MRD) is a promising biomarker in colorectal cancer (CRC) for prognosis and guiding treatment, while the whole-exome sequencing (WES) based tumor-informed assay is standard for evaluating... -
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- Robotics in Cervical Spine Surgery: Feasibility and Safety of Posterior Screw Placement
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Zhou LP, Zhang ZG, Li D, Fang S, Sheng R, Zhang RJ, Shen CL
- KMID: 2540897
- Neurospine.
- 2023 Mar;20(1):329-339.
- doi: 10.14245/ns.2244952.476
Objective: Robot-assisted (RA) techniques have been widely investigated in thoracolumbar spine surgery. However, the application of RA methods on cervical spine surgery is rare due to the complex morphology of... -
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- CycloZ Improves Hyperglycemia and Lipid Metabolism by Modulating Lysine Acetylation in KK-Ay Mice
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Jeon J, Lee D, Kim B, Park BY, Oh CJ, Kim MJ, Jeon JH, Lee IK, Park O, Baek S, Lim CW, Ryu D, Fang S, Auwerx J, Kim KT, Jung HY
- KMID: 2546124
- Diabetes Metab J.
- 2023 Sep;47(5):653-667.
- doi: 10.4093/dmj.2022.0244
Background: CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode of action remains to be elucidated. Methods: KK-Ay mice, a type 2 diabetes mellitus (T2DM) model,... -
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