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Intracranial Vasospasm without Intracranial Hemorrhage due to Acute Spontaneous Spinal Subdural Hematoma

Oh JH, Jwa SJ, Yang TK, Lee CS, Oh K, Kang JH

Spontaneous spinal subdural hematoma (SDH) is very rare. Furthermore, intracranial vasospasm (ICVS) associated with spinal hemorrhage has been very rarely reported. We present an ICVS case without intracranial hemorrhage following...
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The Effect of Donor-Dependent Administration of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells following Focal Cerebral Ischemia in Rats

Park HW, Chang JW, Yang YS, Oh W, Hwang JH, Kim DG, Paek SH

Stroke is an ischemic disease caused by clotted vessel-induced cell damage. It is characterized by high morbidity and mortality and is typically treated with a tissue plasminogen activator (tPA). However,...
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Pattern of Respiratory Deterioration in Sporadic Amyotrophic Lateral Sclerosis According to Onset Lesion by Using Respiratory Function Tests

Kim DG, Hong YH, Shin JY, Lee KW, Park KS, Seong SY, Sung JJ

Most amyotrophic lateral sclerosis (ALS) patients show focal onset of upper and lower motor neuron signs and spread of symptoms to other regions or the other side clinically. Progression patterns...
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Rosmarinic Acid Alleviates Neurological Symptoms in the G93A-SOD1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Seo JS, Choi J, Leem YH, Han PL

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons in the brain and spinal cord, resulting in paralysis of voluntary skeletal muscles and eventually death, usually within...
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The Role of Oxidative Stress in Neurodegenerative Diseases

Kim GH, Kim JE, Rhie SJ, Yoon S

Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The brain is one of organs...
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Is Oxytocin Application for Autism Spectrum Disorder Evidence-Based?

Lee SY, Lee AR, Hwangbo R, Han J, Hong M, Bahn GH

Autism spectrum disorder (ASD) is characterized by persistent deficits within two core symptom domains: social communication and restricted, repetitive behaviors. Although numerous studies have reported psychopharmacological treatment outcomes for the...
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New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences

Penagarikano O

Autism spectrum disorder (ASD) is characterized by impairment in two behavioral domains: social interaction/communication together with the presence of stereotyped behaviors and restricted interests. The heterogeneity in the phenotype among...
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Exploring the Validity of Valproic Acid Animal Model of Autism

Mabunga DF, Gonzales E, Kim JW, Kim KC, Shin CY

The valproic acid (VPA) animal model of autism spectrum disorder (ASD) is one of the most widely used animal model in the field. Like any other disease models, it can't...
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Characteristics of Brains in Autism Spectrum Disorder: Structure, Function and Connectivity across the Lifespan

Ha S, Sohn IJ, Kim N, Sim HJ, Cheon KA

Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by impaired social communication and restricted and repetitive behaviors (RRBs). Over the past decade, neuroimaging studies have provided considerable...
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Genetics of Autism Spectrum Disorder: Current Status and Possible Clinical Applications

Yoo H

Autism spectrum disorder (ASD) is one of the most complex behavioral disorders with a strong genetic influence. The objectives of this article are to review the current status of genetic...
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