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Sustained Expression of Neuritin mRNA After Repeated Electroconvulsive Stimulations in the Rat Hippocampal Formation

Park KW, Kim IH, Sun W, Kim H

In the present study, we compared the expression patterns of neuritin mRNA in the dentate gyrus of hippocampal formation following single (1xECS) or repeated elctroconvulsive seizures (8xECS) treatments to the...
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Manganese-Enhanced Magnetic Resonance Imaging of the Spinal Cord in Rats

Cha MH, Lee C, Cho JH, Chung MA, Sohn JH, Cheong C, Lee HJ, Lee BH

Manganese-enhanced magnetic resonance imaging (MEMRI) offers a novel neuroimaging method in visualizing the activity patterns of neural circuits. MEMRI is using the divalent manganese ion, which has been used as...
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Regulation of the Activity of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 by Zinc in Rat Primary Astrocytes

Lee SY, Kim HJ, Joo SH, Kwon KJ, Lee J, Han SH, Cho JY, Cheong JH, Ko KH, Shin CY

Tissue-type plasminogen activator (tPA) is a serine proteinase which plays important roles in functional and structural synaptic plasticity, neural migration, as well as excitotoxic injuries in several pathological situations including...
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Differentiation of Rat Neural Stem Cells Following Transplantation in the Brain of Huntington's Disease Rat Model

Ryu HL, Lee SY, Park K, Kim C, Jin BK, Min CK

Stem cells provide an important means for regenerative medicine due to the capacity to generate multiple types of differentiated cells and at the same time to maintain self-renewal. To identify...
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Association of Glutatione S-Transferase (GSTM1 and GSTT1) Gene Deletions in Korean Patients with Alcoholism

Tai ZL, Uhm YK, Kim JW, Yim SV

Alcoholism is caused by a complex interaction between genetic and environmental factors. Findings obtained from several studies indicate that some tissue damage occurring in alcohol abusers is due to the...
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Effects of 6-hydroxydopamine on the Adult Neurogenesis of Dopaminergic Neurons in the Mouse Midbrain

Kim TW, Kim H, Sun W

Recently, restricted progenitor cells have been identified in the substantia nigra (SN) of the rat and mouse, raising a hope that resident stem/progenitor cells may be useful for the therapy...
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Topographical Propagation of alpha-synuclein Pathology in Parkinson's Disease: Phenomenology and Hypothetical Mechanism

Hyun M, Lee SJ

Parkinson's disease is an age-related, slowly progressing neurodegenerative disorder characterized by abnormal deposition of aggregated alpha-synuclein in neuronal cell bodies (Lewy bodies) and neurites (Lewy neurites), as well as in...
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Celecoxib Attenuates Kainic Acid-induced Neuronal Cell Death Through Suppression of Microglial c-Jun N-terminal Kinase Phosphorylation

Byun JS, Cho SY, Kim SI, Kwon YS, Jeon SH, Kim MJ, Lee HJ, Kim SS, Chun W

In the present study, neuroprotective property of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, and its underlying mechanism were examined in the animal model of kainic acid (KA)-induced excitotoxicity. KA, administered...
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Repeated Exposure to beta-phenylethylamine Produces Locomotor Sensitization to Amphetamine, but Not Vice Versa, in the Rat

Park HK, Na JC, Jang JK, Kim JH

Repeated administration of amphetamine (AMPH) produces behavioral sensitization, a proposed model for the escalation of drug use characteristic of human addicts. beta-Phenylethylamine (PEA) is an endogenous trace amine found in...
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Gabapentin Attenuates the Activation of Transient Receptor Potential A1 by Cinnamaldehyde

Bang S, Yoo S, Hwang SW

Gabapentin is used as an effective drug for relieving pain, but the main mechanism is still unclear. Recently, voltage-gated Ca2+ channel subunits are suggested for the main target for the...
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